Artesunate, a potential drug for treatment of Babesia infection

Goo, Youn‐Kyoung; Terkawi, Mohamad Alaa; Jia, Honglin; Aboge, Gabriel Oluga; Ooka, Hideo; Nelson, Bryce; Kim, Suk; Sunaga, Fujiko; Namikawa, Kazuhiko; Igarashi, Ikuo; Nishikawa, Yoshifumi; Xu, Xuan

doi:10.1016/j.parint.2010.06.004

Cited by 52 publications

(39 citation statements)

References 35 publications

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“…Among the 19 drugs, 15 were completely ineffective or had low inhibitory rates on B. microti in BALB/c mice, and some of the drugs were antimalarial agents usually used for the treatment of babesiosis. The EIR of artesunate was only 41.3% at a dose of 100 mg/kg, which is different from what was reported in other studies [24]. However, atovaquone displayed a higher inhibitory rate without completely clearing parasitemia in BALB/c mice, which was similar to findings in Mongolian gerbils [25] and hamsters [18,26].…”

Section: Discussioncontrasting

confidence: 79%

Inhibitory effects of 19 antiprotozoal drugs and antibiotics on Babesia microti infection in BALB/c mice

Yao

Zhang

Liu

et al. 2015

J Infect Dev Ctries

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Introduction: Different results have been achieved in the evaluation of antiparasitic drug activity in Mongolian jirds, hamsters, and BALB/c mice infected with Babesia microti. The aims of the present study were to find a preferable method for drug screening and to re-evaluate the activity of several drugs against B. microti. Methodology: The activity of 19 drugs on B. microti-infected BALB/c mice was evaluated. The study was built on Peters' four-day suppressive test, and the pathogenicity of the blood from the treated mice was also used as indicator. Results: The results showed that 15 of the 19 drugs had little or no in vivo effect against B. microti. The inhibitory rates of atovaquone and azithromycin were high at all doses, but the microscopy-negative blood of recovered mice was still infectious. Similar to robenidine hydrochloride at 25 and 50 mg/kg, primaquine at 100 mg/kg had a 100% inhibitory rate. Robenidine hydrochloride achieved a 100% inhibitory rate at 100 mg/kg, and the blood of recovered mice did not result in parasitemia in subpassage experiments. Parasite-negative blood from mice treated with antimalarial drugs (clinically used for babesiosis) still caused parasitemia in subpassage experiments. This suggests that these drugs cannot eradicate the parasites. Conclusions: Peters' four-day suppressive test and the pathogenicity of the blood from the treated mice are suitable methods for preliminary investigating possible drugs against B. microti. Considering that robenidine hydrochloride achieved the best activity against B. microti in BALB/c mice in our study, further studies are needed.

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Section: Discussioncontrasting

confidence: 79%

Inhibitory effects of 19 antiprotozoal drugs and antibiotics on Babesia microti infection in BALB/c mice

Yao

Zhang

Liu

et al. 2015

J Infect Dev Ctries

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“…22 B. microti appears to be responsive to artemisinin derivatives, as per the study on a mouse model. 23 But there is still not enough data or studies to confirm that artemisinin derivatives are effective to eliminate Babesia infection in humans.…”

Section: Discussionmentioning

confidence: 99%

Emergence of human babesiosis along the border of China with Myanmar: detection by PCR and confirmation by sequencing

Zhou¹,

Wang

et al. 2014

Emerging Microbes & Infections

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Babesiosis is a tick-borne, zoonotic disease caused by Babesia spp. Two cases of babesiosis were detected by nested polymerase chain reaction (PCR) in Yunnan province, China, and further confirmed by molecular assay. The blood smears showed intraerythrocytic ring form and tetrads typical of small B. microti. In both cases, the rapid diagnostic test (RDT) ruled out the possibility of co-infections with malaria. Neither case was initially diagnosed because of the low Babesia parasitemia. These two cases of babesiosis in areas along the Myanmar–China border pose the question of the emergence of this under recognized infection in countries or areas where malaria is endemic.

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“…Other drugs (e.g. quinuronium sulfate, trypan blue solution, parvaquone) are rarely used, or are in the experimental phase such as artesunate and epoxomicin [191,192].…”

Section: Treatmentmentioning

confidence: 99%

Canine Babesiosis: Where Do We Stand?

et al. 2018

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Canine babesiosis is a tick-borne disease caused by protozoal haemoparasites of different Babesia species. Babesiosis is one of the most important globally extended and quickly spreading tick-borne infections of dogs. This comprehensive review gives an in-depth overview of Babesia species currently identifi ed in dogs together with relevant vector tick species and their geographical distribution, life cycle and transmission of parasite. The main mechanisms in the pathogenesis of babesiosis are described and elucidated by recent literature overview. As Babesia infection causes a disease with very variable clinical manifestations, special attention is given to clinical signs, laboratory features and clinicopathological fi ndings. The diagnosis of canine babesiosis by microscopy, serological and molecular methods is reviewed, together with recent advances in mass spectrometry based assays. Accurate detection and species recognition are important for the selection of the appropriate therapy, monitoring and prediction of the outcome of the disease. Finally, guidelines for the treatment and prevention of canine babesiosis are given.

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Artesunate, a potential drug for treatment of Babesia infection

Cited by 52 publications

References 35 publications

Inhibitory effects of 19 antiprotozoal drugs and antibiotics on Babesia microti infection in BALB/c mice

Inhibitory effects of 19 antiprotozoal drugs and antibiotics on Babesia microti infection in BALB/c mice

Emergence of human babesiosis along the border of China with Myanmar: detection by PCR and confirmation by sequencing

Canine Babesiosis: Where Do We Stand?

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