Arteriovenous Brain Malformations: Is Functional MR Imaging Reliable for Studying Language Reorganization in Patients? Initial Observations

Lehericy, Stéphane; Biondi, Alessandra; Sourour, Nader; Vlaicu, Michaela; Montcel, Sophie Tézenas du; Cohen, Laurent; Vivas, Elío; Laurent, Césari; Faillot, Thierry; Casasco, A.; Bihan, Denis Le; Marsault, C.

doi:10.1148/radiol.2233010792

Cited by 116 publications

(54 citation statements)

References 48 publications

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“…Tumors and congenital lesions may cause neurovascular coupling, compromising the blood oxygen level-dependent functional MR imaging signal in the regional eloquent cortex (2,5,(41)(42)(43). The area of motor cortex activation is influenced by the rate and force of contractions (44)(45)(46)(47)(48)(49)(50)(51).…”

Section: Figurementioning

confidence: 99%

Motor Homunculus: Passive Mapping in Healthy Volunteers by Using Functional MR Imaging—Initial Results

Koçak

Ulmer

Uğurel³

et al. 2009

Radiology

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Purpose:To determine the concurrence of activation in the primary motor cortex, induced by paradigms of active and passive movement of extremities, by using blood oxygen leveldependent functional magnetic resonance (MR) imaging. Materials and Methods:The HIPAA-compliant study was approved by the institutional review board, and written informed consent was obtained from the participating volunteers. Functional MR imaging data were collected from 11 healthy volunteers (four women, seven men; age range, 24 -42 years) during active and passive movements of hand, elbow, shoulder, ankle, knee, and hip. These data were then mapped onto three-dimensional anatomic images. Volumes of activation were determined by using cross-correlation analysis at a coefficient threshold of 0.4 (P Ͻ .01). Regions of interest were drawn in pre-and postcentral gyri based on anatomic criteria. The mean number of activated voxels in the preand postcentral gyri induced by active and passive movements was compared by using Wilcoxon analysis. Concurrence ratios and proportional ratios of activation between active and passive movements were calculated for each somatotopic location.

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Section: Figurementioning

confidence: 99%

Motor Homunculus: Passive Mapping in Healthy Volunteers by Using Functional MR Imaging—Initial Results

Koçak

Ulmer

Uğurel³

et al. 2009

Radiology

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“…As previously stated, concordance with the IAP is high for TLE, but may drop to 75% or lower in patients with extratemporal epilepsy. Finally, there is evidence that the hemodynamic response in fMRI is suppressed in a sizable number of patients with lesions that result in abnormal vascularization (82,83), making fMRI unreliable in many patients with large gliomas or AVMs. Nevertheless, fMRI provides a cost-efficient, noninvasive method of language and memory localization, and its wide availability makes it a strong contender for eventually replacing the IAP.…”

Section: Fmrimentioning

confidence: 99%

The use of neuroimaging to study behavior in patients with epilepsy

McDonald¹

2008

Epilepsy & Behavior

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Structural and functional neuroimaging continue to play an increasing role in the presurgical evaluation of patients with epilepsy. In addition to their value for localizing the epileptogenic zone and eloquent cortex, neuroimaging is contributing to our understanding of mood comorbidity in epilepsy. Although the vast majority of research has focused on patients with temporal lobe epilepsy (TLE), neuroimaging studies of patients with frontal lobe epilepsy (FLE) and primary generalized epilepsy are increasing in number. In this review, structural and functional imaging modalities that have received considerable research attention in recent years are reviewed, along with an assessment of their strengths and limitations for understanding behavior in epilepsy. In addition, advances in multimodal imaging are discussed along with their potential application to the presurgical evaluation of patients with seizure disorders.

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“…As suggested by other studies (Lehericy et al 2002;Ries et al 2004;Thivard et al 2005), the language reorganization should be explored at regional rather than at hemispheric level, because the reorganisation pattern depend on the region taken into account. Furthermore, the reorganisation of temporal regions occurs more frequently than the reorganisation of frontal regions.…”

Section: Cousin Et Almentioning

confidence: 99%

“…Indeed, they showed that language reorganization occurs in pre-existing bilateral networks which could not be detected preoperatively but postoperatively. This pattern, also called "translocation of language function" (Lazar et al 1997), is interpreted as an over-activity of frontal region with probably taking into account the function of other language regions, such as the posterior (temporo-parietal) ipsilateral areas (Lehericy et al 2002). This pattern could also refl ect lower involvement of temporal regions during language, due to their pathological condition (Ries et al 2004).…”

Section: Frontal Regionmentioning

confidence: 99%

Functional MRI evidence for language plasticity in adult epileptic patients: Preliminary results

Baciu¹

2008

NDT

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The present fMRI study explores the cerebral reorganisation of language in patients with temporal lobe epilepsy, according to the age of seizures onset (early or late) and the hippocampal sclerosis (associated or not). Seven right-handed control volunteers and seven preoperative adult epileptic patients performed a rhyme decision (language condition) and a visual detection (control condition) tasks in visually presented words and unreadable characters, respectively. All patients were left hemisphere dominant for language. Appropriate statistical analyses provided the following preliminary results: (1) patients compared with healthy subjects showed lower degree of hemispheric lateralization with supplementary involvement of the right hemisphere; (2) the degree of hemispheric specialization depends on the considered region; (3) patients with early seizures show signs of temporal and parietal reorganization more frequently than patients with late onset of seizures; (4) patients with early seizures show a tendency for intra-hemispheric frontal reorganisation; (5) associated hippocampal sclerosis facilitates the inter-hemispheric shift of temporal activation. Although our patients were left hemisphere predominant for language, the statistical analyses indicated that the degree of lateralization was signifi cantly lower than in healthy subjects. This result has been considered as the indication of atypical lateralization of language.

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Arteriovenous Brain Malformations: Is Functional MR Imaging Reliable for Studying Language Reorganization in Patients? Initial Observations

Abstract: These data suggest that flow abnormalities may interfere with language lateralization assessment with functional MR imaging.

Cited by 116 publications

References 48 publications

Motor Homunculus: Passive Mapping in Healthy Volunteers by Using Functional MR Imaging—Initial Results

Motor Homunculus: Passive Mapping in Healthy Volunteers by Using Functional MR Imaging—Initial Results

The use of neuroimaging to study behavior in patients with epilepsy

Functional MRI evidence for language plasticity in adult epileptic patients: Preliminary results

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