Arteriosclerosis carotídea subclínica en pacientes con hiperlipidemia familiar combinada. Evolución tras dos años de tratamiento con dosis altas de atorvastatina

Martínez-Hervás, Sergio; Priego, Antonia; Lorente, Rosario I.; Molina, Mercedes; Navarro-Hidalgo, M. Inmaculada; Real, José T.; Ascaso, Juan F.

doi:10.1016/j.medcli.2010.12.009

Cited by 3 publications

(5 citation statements)

References 24 publications

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“…In accordance with a previous diagnosis or the use of LLT, data indicated that between 50% and 84% of DM patients would present with hypercholesterolemia [ 44 , 57 , 65 – 68 ].…”

Section: Resultsmentioning

confidence: 75%

Prevalence, Treatment, and Control of Hypercholesterolemia in High Cardiovascular Risk Patients: Evidences from a Systematic Literature Review in Spain

et al. 2015

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IntroductionCardiovascular diseases (CVDs) represent a major Public Health burden. High serum cholesterol levels have been linked to major CV risk. The objectives of this study were to review the epidemiology of hypercholesterolemia in high risk CV patients from Spain, by assessing its prevalence, the proportion of diagnosed patients undergoing pharmacological treatment and the degree of attained lipid control.MethodsA systematic literature review was carried out using Medline and two Spanish databases. Manuscripts containing information on hypercholesterolemia in several high CV risk groups [diabetes mellitus (DM), Systematic COronary Risk Evaluation (SCORE) risk >5, or documented CVD], published between January 2010 and October 2014, were included.ResultsOf the 1947 published references initially retrieved, a full-text review was done on 264 manuscripts and 120 were finally included. Prevalence of hypercholesterolemia ranged from 50 to 84% in diabetics, 30–60% in patients with DM or elevated SCORE risk, 64–74% with coronary heart disease, 40–70% in stroke patients, and 60–80% in those with peripheral artery disease. Despite the finding that most of them were on pharmacological treatment, acceptable control of serum lipids was very variable, ranging from 15% to 65%. Among those with heterozygous familial hypercholesterolemia, 95–100% received treatment but less than 50% achieved their therapeutic goals.ConclusionsAn elevated prevalence of hypercholesterolemia can be found in targeted groups at high CV risk. Although most patients are receiving pharmacological treatment, rates of lipid control continue to be low, both in primary and secondary prevention.Electronic supplementary materialThe online version of this article (doi:10.1007/s12325-015-0252-y) contains supplementary material, which is available to authorized users.

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“…In accordance with a previous diagnosis or the use of LLT, data indicated that between 50% and 84% of DM patients would present with hypercholesterolemia [ 44 , 57 , 65 – 68 ].…”

Section: Resultsmentioning

confidence: 75%

Prevalence, Treatment, and Control of Hypercholesterolemia in High Cardiovascular Risk Patients: Evidences from a Systematic Literature Review in Spain

et al. 2015

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“…Although the benefit of the specific study of thrombophilia in RVO is not established, 8,9,12,13,21,22 based on our results, it seems reasonable to rule out antiphospholipid syndrome in all the patients. The remainder of the hypercoagulability study seems advisable only in young patients (younger than 50 years), those who are older but have no VRFs and those who present thrombosis at other levels.…”

Section: Discussionmentioning

confidence: 68%

“…1,2 The mean age at onset of RVO is approximately 65 years. 1,7,8 Another predisposing, albeit local factor is glaucoma, which in obstructing the venous return favors the onset of RVO (generally the central type). 4,5 The classical vascular risk factors (VRFs) such as high blood pressure, dyslipidemia, diabetes mellitus, smoking and hyperhomocysteinemia are the primary etiopathogenetic agents of RVO.…”

Section: Introductionmentioning

confidence: 99%

Thrombophilia and vascular risk factors in retinal vein occlusion

Lecumberri

Balbas

Villanueva

et al. 2013

Revista Clínica Española (English Edition)

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“…Aunque no está establecido el beneficio del estudio específico de trombofilia en la OVR 8,9,12,13,21,22 , de acuerdo con nuestros resultados, parece razonable descartar el síndrome antifosfolípido en todos los pacientes. El resto del estudio de hipercoagulabilidad parece recomendable solamente en los pacientes jóvenes (menores de 50 años), aquellos de mayor edad sin FRV o los que presenten trombosis a otros niveles.…”

Section: Discussionunclassified

“…Por lo tanto, en este contexto, la OVR constituiría una manifestación del proceso arterioescleroso 6 . Además, la existencia de lesiones ateromatosas carotídeas se ha asociado con la presencia de OVR y con el pronóstico de la misma 1,7,8 . Otro factor predisponente, pero a nivel local, es el glaucoma, que al dificultar el retorno venoso, favorece su aparición, generalmente de tipo central.…”

Section: Introductionunclassified