2002
DOI: 10.1006/mvre.2002.2451
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Arteriolar Flow Recruitment with Vitronectin Receptor Stimulation Linked to Remote Wall Shear Stress

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Cited by 9 publications
(19 citation statements)
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“…This is illustrated by α v β 3 integrin ligation, in which there is first an abrupt elevation in velocity of flow into the network, followed by a flow- and gap junction-mediated dilation. In this case, recruited flow exclusively travels to the branch of the network that was stimulated, to the extent that flow is stolen from other branches of the network [16]. The present study suggests that flow recruitment with FGF2 would be general, while recruitment with VEGF-A would be specific.…”
Section: Discussionmentioning
confidence: 93%
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“…This is illustrated by α v β 3 integrin ligation, in which there is first an abrupt elevation in velocity of flow into the network, followed by a flow- and gap junction-mediated dilation. In this case, recruited flow exclusively travels to the branch of the network that was stimulated, to the extent that flow is stolen from other branches of the network [16]. The present study suggests that flow recruitment with FGF2 would be general, while recruitment with VEGF-A would be specific.…”
Section: Discussionmentioning
confidence: 93%
“…One important assumption is that we presume that the excess volume flow travels to only the downstream capillary bed fed by the terminal arteriole that was stimulated. This is based on our prior work showing that the excessred blood cell flux travels only to the stimulated downstream branch in experiments with α v β 3 integrin ligation [16]. Next we estimated the downstream surface area for exchange using a published value for a typical capillary grouping (module) with a total length of approximately 2,800 µm [28] and average capillary diameter of 5 µm (hamster red blood cell is 5 µm); surface area per module is 4.4 × 10 –4 cm 2 /module.…”
Section: Discussionmentioning
confidence: 99%
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