2020
DOI: 10.1111/bjh.16792
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Arterial thromboembolic complications in COVID‐19 in low‐risk patients despite prophylaxis

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Cited by 45 publications
(44 citation statements)
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“…It is unclear whether the same mechanisms are involved in venous as in arterial clots. Arterial clots in COVID-19 patients removed at the time of surgery [28] have been consistent with being platelet-rich which suggests that anti-platelet agents may have a role to play in preventing arterial complications.…”
Section: Discussionmentioning
confidence: 79%
See 1 more Smart Citation
“…It is unclear whether the same mechanisms are involved in venous as in arterial clots. Arterial clots in COVID-19 patients removed at the time of surgery [28] have been consistent with being platelet-rich which suggests that anti-platelet agents may have a role to play in preventing arterial complications.…”
Section: Discussionmentioning
confidence: 79%
“…Helms et al only reported four (2.6%) cases in a cohort study of 150 COVID-19 ICU patients [7]. Arterial complications may result in major morbidity as highlighted in recent case reports [27,28]. It is unclear whether the same mechanisms are involved in venous as in arterial clots.…”
Section: Discussionmentioning
confidence: 99%
“…Interestingly Oxley et al noted an increased occurrence of younger SARS CoV2 virus-infected patients with no significant traditional risk factors for AIS, presenting with large vessel occlusion (6). Putative mechanisms suggested as inducing AIS in association with SARS CoV2 have included systemic inflammation, inflammatory cytokine storm, hyper-coagulability, and imbalances in the classical and alternative Renin Angiotensin System (RAS) in relation to SARS-CoV-2 spike glycoprotein-ACE2 binding related molecular mechanisms (3,(7)(8)(9)(10)(11)(12)(13)(14)(15)(16)(17)(18)(19)). The RAS system comprises both a plasmabased RAS regulating cardiovascular system and tissue-based RAS regulating long term changes via a complex hormonal system, endocrine, paracrine, and autocrine in action.…”
Section: Introductionmentioning
confidence: 99%
“…It is possible that the cause of his acute arterial thrombosis was DIC, but it is also possible that COVID-19 contributed to his hypercoagulability by a yet unknown mechanism. The prevalence of these arterial and venous thromboses in COVID-19 is well documented in the literature [ 1 - 3 , 5 - 8 ].…”
Section: Discussionmentioning
confidence: 99%
“…A retrospective study of venous thromboembolism (VTE) incidence in 26 patients with COVID-19 by Llitjos et al demonstrated that 100% (n = 8) of those on prophylactic dose anticoagulation, and 56% (n = 10) of those on therapeutic dose anticoagulation experienced VTE [ 6 ]. A case report by Griffen et al described an individual on therapeutic enoxaparin who also developed acute ischemia of the lower limb [ 8 ]. The risk of thromboembolic events and the sheer magnitude of COVID-19-associated admissions have prompted many hospitals to establish novel protocols with which these individuals are provided anticoagulation at increased or even therapeutic doses compared to the more common prophylactic dose.…”
Section: Discussionmentioning
confidence: 99%