Arterial stiffness parameters associated with vitamin D deficiency and supplementation in patients with normal cardiac functions

Sünbül, Murat; Çinçin, Altuğ; Bozbay, Mehmet; Mammadov, Ceyhun; Atas, Halil; Ozsenel, Ekmel Burak; Sarı, İbrahim; Başaran, Yelda

doi:10.5543/tkda.2015.93237

Cited by 4 publications

(3 citation statements)

References 11 publications

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“…The findings of the present study were similar to a previous study that demonstrated significant decrease in pulse wave velocity from baseline (6.8 [1.55] m/s vs. 6.4 [1.3] m/s) following oral administration of 50,000 IU of Vitamin D 3 /week for 8 weeks followed by 2000 IU/day for 4 weeks in patients with Vitamin D deficiency. [17]…”

Section: Discussionmentioning

confidence: 99%

“…demonstrated significant reduction in augmentation index from baseline (31 [14.5]% vs. 23 22%) with oral Vitamin D 3 supplementation (50,000 IU/week for 8 weeks and maintenance dose of 2000 IU/day for 4 weeks) in patients with Vitamin D deficiency. [17] However, a randomized controlled study showed no change in augmentation index with Vitamin D supplementation (2500 IU/day for 4 months) in postmenopausal women with serum Vitamin D levels ranging between 10 and 60 ng/ml. [14] Similarly, another randomized controlled trial evaluating the effect of Vitamin D supplementation (400 IU or 2500 IU/day for 6 months) showed no difference in aortic systolic blood pressure, aortic pulse pressure, and augmentation index between high dose and low dose Vitamin D group in healthy postmenopausal women.…”

Section: Discussionmentioning

confidence: 99%

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Effect of Vitamin D supplementation on vascular functions and oxidative stress in type 2 diabetic patients with Vitamin D deficiency

Anandabaskar

Selvarajan

Dkhar

et al. 2017

Indian J Endocr Metab

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Background:Vitamin D levels are reported to have an inverse liaison with the risk of cardiovascular diseases. Hence, we aimed to evaluate the effect of Vitamin D supplementation on changes in vascular functions and oxidative stress in type 2 diabetic patients with Vitamin D deficiency.Subjects and Methods:One hundred and three patients with type 2 diabetes attending endocrinology outpatients department in a tertiary care hospital were screened for Vitamin D deficiency. Patients with serum 25-hydroxy Vitamin D levels <20 ng/ml were considered as deficient and were administered 60,000 IU of oral Vitamin D3 weekly for 8 weeks. In these patients, parameters of vascular functions (carotid-femoral pulse wave velocity, brachial-ankle pulse wave velocity, and arterial stiffness index) and oxidative stress (serum malondialdehyde levels and total antioxidant status) were measured at baseline and after 8 weeks of oral Vitamin D supplementation.Results:Among 103 patients with type 2 diabetes, 75 (72.82%) were found to have Vitamin D deficiency. Amidst these patients, carotid-femoral pulse wave velocity (991.6 ± 161.82 vs. 899.29 ± 151.86, P < 0.001), right brachial-ankle pulse wave velocity (1446.16 ± 204.33 vs. 1350.8 ± 178.39, P < 0.001), and left brachial-ankle pulse wave velocity (1493.81 ± 219.65 vs. 1367.61 ± 220.64, P < 0.001) showed a significant reduction following Vitamin D supplementation. Further, these patients were found to have significant fall in serum malondialdehyde levels with rise in total antioxidant status ensuing Vitamin D supplementation.Conclusion:The present study shows that oral Vitamin D supplementation of 60,000 IU/week for 8 weeks significantly improves vascular functions and reduces oxidative stress in type 2 diabetic patients with Vitamin D deficiency.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Effect of Vitamin D supplementation on vascular functions and oxidative stress in type 2 diabetic patients with Vitamin D deficiency

Anandabaskar

Selvarajan

Dkhar

et al. 2017

Indian J Endocr Metab

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“…Some studies have shown that vitamin D supplementation improves vascular functions and reduces oxidative stress in vitamin D deficient patients. [62][63][64] A randomized controlled trial has demonstrated the beneficial effects of calcium and vitamin D supplementation in reducing cancer risk in postmenopausal women. 65 There are also conflicting results with the use of vitamin D supplementation in prevention of cardiovascular diseases or cancer.…”

Section: Vitamin D Deficiencymentioning

confidence: 99%

Vitamin D in Health and Disease – An Update

Anandabaskar¹,

Selvarajan²,

Kamalanathan³

2018

JYP

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Although rickets was prevalent from time immemorial, there was lack of knowledge regarding its etiology and treatment, until the discovery of vitamin D. 1 In 1890, it was observed that prevalence of rickets was more in London compared to that in the tropical zones like India and China. This observation led to the speculation that exposure to sunlight was essential for prevention of rickets. 2 Similarly experiments by Mellan by et al. 3 in the year 1919, found that cod liver oil could cure rickets in dogs retained indoors without access to sunlight. The study concluded that probably vitamin A or a similar substance present in cod liver oil was responsible for the improvement in symptoms of rickets in the dogs and that rickets was produced due to deficiency of vitamin A in the diet. However, a subsequent study done by McCollum et al. 4 in the year 1922, revealed that a new fat soluble vitamin (which they named as vitamin D) distinct from vitamin A, was responsible for the cure of rickets in dogs. This discovery was based on the finding that cod liver oil with vitamin A destroyed by oxidation, could not prevent the occurrence of xerophthalmia but still demonstrated the antirachitic effect in dogs. Following its discovery, various researchers like Windaus, Thiele, Schenck and Werder identified the structure and properties of vitamin D, which is derived from both plant and animal sources. 5 VITAMIN D-A VITAMIN OR PROHORMONE? Vitamin a micronutrient, essential for the survival of an organism is not synthesized in the body but is derived from dietary sources. Although vitamin D was initially classified as a vitamin, accumulating evidence indicated that it can be produced in our body with the help of ultraviolet radiation from sunlight, thus violating the definition of a vitamin. Thus, vitamin D is now thought to be a prohormone which on subsequent activation in the body gets converted to its active form 1,25-dihydroxy vitamin D which functions like a hormone (produced in one part of

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Low 25-hydroxyvitamin D is associated with arterial stiffness in Chinese with Type 2 diabetes mellitus

Chen

Sheng³

et al. 2021

Eur J Clin Nutr

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Arterial stiffness parameters associated with vitamin D deficiency and supplementation in patients with normal cardiac functions

Abstract: Vitamin D supplementation has beneficial effects on arterial stiffness. Arterial stiffness parameters may aid in the assessment of cardiovascular risk in patients with vitamin D deficiency.

Cited by 4 publications

References 11 publications

Effect of Vitamin D supplementation on vascular functions and oxidative stress in type 2 diabetic patients with Vitamin D deficiency

Effect of Vitamin D supplementation on vascular functions and oxidative stress in type 2 diabetic patients with Vitamin D deficiency

Vitamin D in Health and Disease – An Update

Low 25-hydroxyvitamin D is associated with arterial stiffness in Chinese with Type 2 diabetes mellitus

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