Arterial stiffness is not increased in teens with early uncomplicated type 1 diabetes mellitus

Yu, Mei‐Ching; Lo, Fu‐Sung; Huang, Wen‐Hung; Lee, Fan

doi:10.1007/s00431-012-1679-7

Cited by 14 publications

(13 citation statements)

References 10 publications

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“…There are a number of cross sectional studies of arterial stiffness in youth with T1D (Haller et al, 2004, Heilman et al, 2009, Palombo et al, 2011, Urbina et al, 2010, Yu et al, 2012) but few prospective studies (Dabelea et al, 2013). Two prospective studies in non-diabetic adults found that the presence of metabolic syndrome (a cluster of CVD risk factors) at baseline was associated with faster progression of arterial stiffness over time (Safar et al, 2006, Tomiyama et al, 2006).…”

Section: Discussionmentioning

confidence: 99%

Insulin sensitivity and arterial stiffness in youth with type 1 diabetes: the SEARCH CVD study

Shah

Black

Wadwa

et al. 2015

Journal of Diabetes and its Complications

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Aims Decreased insulin sensitivity is a cardiovascular risk factor (CVRF) in youth with type 1 diabetes (T1D). Whether baseline insulin sensitivity is independently associated with changes in early arterial stiffness (pulse wave velocity (PWV)) over time in youth with T1D is not known. Methods 298 youth with T1D in the SEARCH CVD study had PWV measured ~five years apart. Insulin sensitivity and other CVRFs were measured at baseline. The association between baseline insulin sensitivity with PWV over time was explored using linear mixed models. Models were adjusted for baseline age, sex and race, with subsequent adjustment for CVRFs. Results There was a significant interaction (p=0. 0326) between baseline insulin sensitivity and time on PWV, independent of CVRFs, indicating that higher insulin sensitivity levels were associated with lower rate of change in PWV over time. Other significant predictors of PWV change were baseline age [β=0.007 (p=0.03) increase in logPWV/ year increase in age] and mean arterial blood pressure (MAP) [β=0.005 (p<0.01) increase in logPWV/ mmHg increase in MAP] and smoking status (current vs. never smoker). Conclusions Lower insulin sensitivity at baseline appears to be an important risk factor for increased arterial stiffness over time in youth with T1D. This identifies a potentially modifiable therapeutic target.

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Section: Discussionmentioning

confidence: 99%

Insulin sensitivity and arterial stiffness in youth with type 1 diabetes: the SEARCH CVD study

Shah

Black

Wadwa

et al. 2015

Journal of Diabetes and its Complications

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“…Another study found higher PWV among 72 children with T1DM with an average age of 12.3 ± 1.6, HbA1c 8.6 ± 1.9%, and diabetes duration of 3.9 ± 2.6 years when compared to 77 HC. In a different study that used brachial-ankle pulse wave velocity as an index of arterial stiffness, no difference was seen among 87 children with T1DM with median HbA1c 9.1% and duration of diabetes 5.1 years compared to 21 HC [ 21 ]. Similar results were also seen in a recent study with 199 youths with T1DM compared to 178 HC [ 22 ].…”

Section: Manifestations Of Subclinical Cardiovascular Diseasementioning

confidence: 99%

Modifiable Risk Factors for Cardiovascular Disease in Children with Type 1 Diabetes: Can Early Intervention Prevent Future Cardiovascular Events?

2017

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Purpose of ReviewPatients with type 1 diabetes have increased risk for cardiovascular disease.The purpose of this review is to examine the following:current evidence for subclinical cardiovascular disease (CVD) in children with type 1 diabetes (T1DM)known modifiable risk factors for CVD and their relationship to subclinical CVD in this populationstudies that have addressed these risk factors in order to improve CVD outcomes in children with T1DM Recent FindingsSubclinical CVD presents in children as increased carotid intima-media thickness, increased arterial stiffness, and endothelial and myocardial dysfunction. Modifiable risk factors for CVD include hyperglycemia, hyperlipidemia, obesity, hypertension, depression, and autonomic dysfunction. Very few randomized controlled studies have been done in children with T1DM to examine how modification of these risk factors can affect their CVD.SummaryChildren with T1DM have subclinical CVD and multiple modifiable risk factors for CVD. More research is needed to define how modification of these factors affects the progression of CVD.

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“…111 Studies that found no increase in arterial stiffness in T1DM used nonstandard methods of assessing arterial stiffness that have not been validated in youth. 112,113 One large study of adolescents with T2DM (n=195) demonstrated increased arterial stiffness (lower brachial distensibility, higher augmentation index and pulse-wave velocity) in adolescents with T2DM compared with either lean or obese control subjects. 114 The only interventional study showed a trend for improvement in augmentation index with statin administration in youth with T1DM (n=51).…”

mentioning

confidence: 99%

Cardiovascular Disease Risk Factors in Youth With Diabetes Mellitus

Maahs¹,

Daniels²,

Ferranti³

et al. 2014

Circulation

159

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Arterial stiffness is not increased in teens with early uncomplicated type 1 diabetes mellitus

Cited by 14 publications

References 10 publications

Insulin sensitivity and arterial stiffness in youth with type 1 diabetes: the SEARCH CVD study

Insulin sensitivity and arterial stiffness in youth with type 1 diabetes: the SEARCH CVD study

Modifiable Risk Factors for Cardiovascular Disease in Children with Type 1 Diabetes: Can Early Intervention Prevent Future Cardiovascular Events?

Cardiovascular Disease Risk Factors in Youth With Diabetes Mellitus

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