Arterial stiffness is associated with oxidative stress and endothelial activation among persons with treated HIV in Zambia

Chikopela, Theresa; Goma, Fastone; Kaluba, Longa; Mutale, Wilbroad; Guure, Chris; Heimburger, Douglas C.; Koethe, John R.

doi:10.4102/sajhivmed.v22i1.1298

Cited by 3 publications

(3 citation statements)

References 50 publications

(79 reference statements)

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“…In SSA, the prevalence of infectious diseases, particularly human immunodeficiency virus (HIV), has significant cardiovascular implications. 52 HIV-positive individuals in Zambia show malformations in the vascular endothelial lining, contributing to arterial dysfunction and stiffness. 52 However, studies on HIV in SSA often exclude pregnant women, and specific examination of endothelial function in pregnant HIV-positive individuals is lacking.…”

Section: Underdiagnosing Hypertension and Hdp In Ssamentioning

confidence: 99%

“…52 HIV-positive individuals in Zambia show malformations in the vascular endothelial lining, contributing to arterial dysfunction and stiffness. 52 However, studies on HIV in SSA often exclude pregnant women, and specific examination of endothelial function in pregnant HIV-positive individuals is lacking. 52 Urbanization contributes to increases in sedentary habits and the adoption of Westernized diets rich in saturated fats, sucrose, and salt.…”

Section: Underdiagnosing Hypertension and Hdp In Ssamentioning

confidence: 99%

“…52 However, studies on HIV in SSA often exclude pregnant women, and specific examination of endothelial function in pregnant HIV-positive individuals is lacking. 52 Urbanization contributes to increases in sedentary habits and the adoption of Westernized diets rich in saturated fats, sucrose, and salt. Westernized diets induce metabolic and arterial dysfunction in both mice and humans, fostering conditions such as hypertension, obesity, and diabetes.…”

Section: Underdiagnosing Hypertension and Hdp In Ssamentioning

confidence: 99%

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Hypertension Related Co-Morbidities and Complications in Women of Sub-Saharan Africa: A Brief Review

Hahka,

Slotkowski,

Akbar

et al. 2024

Circulation Research

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Hypertension is the leading cause of cardiovascular disease in women, and sub-Saharan African (SSA) countries have some of the highest rates of hypertension in the world. Expanding knowledge of causes, management, and awareness of hypertension and its co-morbidities worldwide is an effective strategy to mitigate its harms, decrease morbidities and mortality, and improve individual quality of life. Hypertensive disorders of pregnancy (HDPs) are a particularly important subset of hypertension, as pregnancy is a major stress test of the cardiovascular system and can be the first instance in which cardiovascular disease is clinically apparent. In SSA, women experience a higher incidence of HDP compared with other African regions. However, the region has yet to adopt treatment and preventative strategies for HDP. This delay stems from insufficient awareness, lack of clinical screening for hypertension, and lack of prevention programs. In this brief literature review, we will address the long-term consequences of hypertension and HDP in women. We evaluate the effects of uncontrolled hypertension in SSA by including research on heart disease, stroke, kidney disease, peripheral arterial disease, and HDP. Limitations exist in the number of studies from SSA; therefore, we will use data from countries across the globe, comparing and contrasting approaches in similar and dissimilar populations. Our review highlights an urgent need to prioritize public health, clinical, and bench research to discover cost-effective preventative and treatment strategies that will improve the lives of women living with hypertension in SSA.

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Section: Underdiagnosing Hypertension and Hdp In Ssamentioning

confidence: 99%

Section: Underdiagnosing Hypertension and Hdp In Ssamentioning

confidence: 99%

Section: Underdiagnosing Hypertension and Hdp In Ssamentioning

confidence: 99%

See 1 more Smart Citation

Hypertension Related Co-Morbidities and Complications in Women of Sub-Saharan Africa: A Brief Review

Hahka,

Slotkowski,

Akbar

et al. 2024

Circulation Research

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Pathophysiological mechanisms of vascular wall alterations in menopausal women

Dadaeva,

Gebekova,

Drapkina

2024

Rus. J. Prev. Med.

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Nitrotyrosine, Nitrated Lipoproteins, and Cardiovascular Dysfunction in Patients with Type 2 Diabetes: What Do We Know and What Remains to Be Explained?

2022

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Diabetes mellitus (DM) is a strong risk factor for the development of cardiovascular diseases (CVDs), which are the most important cause of morbidity and mortality in the population of patients living with DM. DM is associated with lipid metabolism disorders characterized by a decrease in the high-density lipoprotein blood concentration, an increase in the triglyceride blood concentration, and the presence of modified lipoproteins not routinely measured in clinical practice. Nitrated lipoproteins are produced by the nitration of the tyrosyl residues of apolipoproteins by myeloperoxidase. There is some evidence from the research conducted showing that nitrated lipoproteins may play a role in the development of cardiovascular dysfunction, but this issue requires further investigation. It was found that the nitration of HDL particles was associated with a decrease in caspase-3 and paraoxonase-1 activity, as well as a decrease in the activity of cholesterol transport via ABCA1, which reduces the protective effect of HDL particles on the cardiovascular system. Less information has been collected about the role of nitrated LDL particles. Thus far, much more information has been obtained on the relationship of nitrotyrosine expression with the presence of cardiovascular risk factors and the development of cardiovascular dysfunction. The purpose of this paper is to provide an extensive review of the literature and to present the most important information on the current state of knowledge on the association between nitrotyrosine and nitrated lipoproteins with dysfunction of the cardiovascular system, especially in patients living with DM. Moreover, directions for future research in this area were discussed.

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Arterial stiffness is associated with oxidative stress and endothelial activation among persons with treated HIV in Zambia

Cited by 3 publications

References 50 publications

Hypertension Related Co-Morbidities and Complications in Women of Sub-Saharan Africa: A Brief Review

Hypertension Related Co-Morbidities and Complications in Women of Sub-Saharan Africa: A Brief Review

Pathophysiological mechanisms of vascular wall alterations in menopausal women

Nitrotyrosine, Nitrated Lipoproteins, and Cardiovascular Dysfunction in Patients with Type 2 Diabetes: What Do We Know and What Remains to Be Explained?

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