Arterial stiffness in relation to subclinical atherosclerosis

Wykretowicz, Andrzej; Gerstenberger, Patrick D.; Guzik, Przemysław; Milewska, Agata; Krauze, Tomasz; Adamska, Krystyna; Rutkowska, Agnieszka; Wysocki, Henryk

doi:10.1111/j.1365-2362.2008.02057.x

Cited by 59 publications

(43 citation statements)

References 27 publications

(33 reference statements)

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“…Previous study by Wykretowicz et al (2009) found that SI DVP was not correlated to CIMT. Another study found that among Japanese subjects there was a significant correlation between b/a ratio with CIMT but this correlation was weak (β=0.069) (Tabara et al 2016).…”

Section: Discussionmentioning

confidence: 73%

The Assessment of Finger Photoplethysmography Fitness Index (PPGF) among Young Men with Cardiovascular Disease Risk Factors: A Cross Sectional Study

Aminuddin¹,

Zakaria²,

Chellappan³

et al. 2016

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ABSTRAK Dua petanda kesihatan salur darah baru yang dihasilkan daripada gelombang fotopletismografi jari (PPG) telah diperkenalkan berdasarkan populasi rakyat Malaysia iaitu indeks kecergasan PPG (PPGF) dan indeks jangkaan risiko salur darah (VRPI). Antara objektif kajian ini adalah untuk mengkaji hubungan antara PPGF dengan petanda penyakit jantung (CVD (Beta = 0.35, p < 0.01), p < 0.01), p = 0.04) dan ketinggian (Beta = 0.24, p < 0.01 ABSTRACTTwo new vascular health markers which are derived from finger photoplethysmography (PPG) waveform have been introduced based on Malaysian population, namely PPG fitness index (PPGF) and vascular risk prediction index (VRPI). The objectives of this study were to investigate the associations between PPGF and other cardiovascular disease (CVD) markers such as carotid femoral pulse wave velocity (PWV CF ), to compare PPGF between those with and without CVD risk factors and to determine the sensitivity of VRPI in identifying young subjects with CVD risk factors. A total of 114 men age 20 to 40 yrs with and without CVD risk factors were recruited. Risk factors included hypertension, smoking, dyslipidemia, abdominal obesity and family history of premature CVD. Subjects were divided into healthy, those with one risk factor and those with at least two risk factors. Their weight, height, peripheral and central blood pressure (BP), PWV CF and PPGF were measured and the sensitivity of VRPI in predicting subjects with CVD risk factor was calculated. Data was analyzed via SPSS version 15 and p < 0.05 was considered significant. The mean age of the subjects was 28.94 ± 4.86 yrs. No differences in PPGF was observed between groups (p > 0.05). The independent variables for PPGF were forward pressure (Beta = 0.35, p < 0.01), PWV CF (Beta = -0.26, p < 0.01), systolic BP (Beta = -0.26, p = 0.04) and height (Beta = 0.24, p < 0.01). The sensitivity of VRPI was 82.02%. In conclusion, PPGF was correlated to PWV CF and may be a potential marker of arterial stiffness. In addition, VRPI is sensitive to be used as an early screening of CVD risk factors.

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Section: Discussionmentioning

confidence: 73%

The Assessment of Finger Photoplethysmography Fitness Index (PPGF) among Young Men with Cardiovascular Disease Risk Factors: A Cross Sectional Study

Aminuddin¹,

Zakaria²,

Chellappan³

et al. 2016

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“…Both parameters can be easily measured using noninvasive techniques and have been used in numerous basic and clinical studies thus far; indeed, it has even been stated that E/e' >15 is the best single indirect predictor of elevated LV filling pressure and LV diastolic dysfunction. 7,20 The lack of adjustment of our findings to mean arterial pressure, age, and heart rate as well as diabetes or used medications might be considered as the third potential limitation. However, as we have seen, the 5-covariate model is the largest model possible in this study in view of the sample size.…”

Section: 1424-27mentioning

confidence: 95%

Association between high arterial stiffness and left ventricular filling pressures in patients with acute myocardial infarction

Milewska¹,

Krauze²,

Piskorski³

et al. 2015

Polish Archives of Internal Medicine

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814velocity (e') is the most accurate noninvasive approximation of instantaneous LV filling pressures. 6 An E/e' ratio exceeding 15 (E/e' >15) is considered to indicate abnormally elevated LV filling pressures 7 in various conditions, including acute myocardial infarction (MI). 8Although abnormal myocardial contraction is typical for acute MI, LV diastolic dysfunction also worsens at this time.9 A series of hemodynamic derangements caused by acute MI affects the mechanical and functional properties of arterial walls, including stiffness.10-12 A decrease in LV stroke volume leads to a reflex increase in vascular resistance and cardiac afterload, which may cause higher systolic and diastolic pressure within the left ventricle. 12IntroductIon Various risk factors or cardiovascular diseases (eg, hypertension, diabetes, aging, or ischemic heart disease) predispose towards the development of left ventricular (LV) diastolic dysfunction.1,2 A community-based study that included apparently healthy individuals reported that approximately 20% of the general population had LV diastolic dysfunction (usually asymptomatic).3 Arterial stiffness contributes significantly to the development of LV diastolic dysfunction, and both pathologies share similar risk factors. 4 Increased arterial stiffness worsens prognosis in hypertensive patients with high or very high cardiovascular risk. 5There are several indices of LV diastolic dysfunction, but the ratio of early transmitral flow velocity (E) to early diastolic septal mitral annulus ABstrActIntroductIon High arterial stiffness increases the left ventricular (LV) filling pressures in different cardiac disorders. The association between arterial stiffness and LV filling pressures has not been studied so far in patients with acute myocardial infarction (MI).oBjectIves The aim of the study was to assess the association between arterial stiffness and LV filling pressures in patients with acute MI.PAtIents And methods Arterial stiffness, measured using the digital volume pulse stiffness index (SI DVP ), and LV filling pressures, quantified as the ratio of early transmitral flow velocity to early diastolic septal mitral annulus velocity (E/e'), were evaluated in 263 patients with acute MI (mean age, 63.8 ±11 years; 69 women). The association between high E/e' (>15) and very stiff arteries (SI DVP >18 m/s) was analyzed by logistic regression, with data presented as odds ratios (ORs) and 95% confidence intervals (CIs).results A multivariate logistic regression analysis revealed an association between E/e' >15 and SI DVP >18 m/s (OR, 4.7; 95% CI, 1.8-12.3), independently of female sex (OR, 4.3; 95% CI, 1.4-10.2), LV ejection fraction <35% (OR, 3.1; 95% CI, 1.2-8.2), left atrial volume >34 ml/m 2 (OR, 17.4; 95% CI, 5.8-52.0). There was no significant association between E/e' >15 and previous MI (OR, 2.2; 95% CI, 0.9-5.7).conclusIons High arterial stiffness is an independent risk factor for LV diastolic dysfunction in patients with acute MI. A reduction in arterial stiffness may improve LV ...

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“…In addition, in view of its correlation with coronary atherosclerosis and its capacity to predict incident coronary events, carotid IMT has been proposed as a surrogate marker of coronary atherosclerosis (10). Also pulse wave velocity (PWV) measured by tonometry provides a noninvasive estimate of arterial stiffness and is an independent predictive risk factor for all-cause mortality and cardiovascular mortality (11)(12)(13).…”

Section: Introductionmentioning

confidence: 99%

Abdominal obesity and low-grade systemic inflammation as markers of subclinical organ damage in type 2 diabetes

Dahlén

Tengblad

Länne

et al. 2014

Diabetes & Metabolism

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SummaryAim:The aim of this study was to explore associations between abdominal obesity, inflammatory markers, and subclinical organ damage in 740 patients with type 2 diabetes. Methods:Waist circumference (WC) and sagittal abdominal diameter (SAD) was measured. Blood samples were analyzed for; C-reactive protein (CRP) and IL-6. Carotid intima-media thickness (IMT) was evaluated by ultrasonography. Aortic pulse wave velocity (PWV) was measured with applanation tonometry. Results:Abdominal obesity measured as SAD and WC were significantly correlated with; IL-6 (WC r=0.27, p<0.001, SAD r=031, p<0.001 ), CRP (WC r=0,29, p <0.001, SAD r=0,29, p <0.001), IMT (WC r=0.09 p=0.013, SAD r=0.11, p=0.003) and PWV (WC r=0.18, p<0.001, SAD r=0.21, p <0.001). In multiple linear regressions with IMT or PWV as dependent variable and age, sex, statins, systolic blood pressure (SBP), Body Mass Index (BMI), CRP and HbA1c, as independent variables, both SAD and WC, remained associated with IMT and PWV. In stepwise linear regression, entering both SAD and WC, the association between SAD and PWV was stronger than the association between WC and PWV. Conclusion:We conclude that SAD and WC are feasible measures of obesity that provides information on inflammation, atherosclerosis and arterial stiffness in type 2 diabetes. However, SAD was slightly more robustly associated to subclinical organ damage, compared with WC.

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Arterial stiffness in relation to subclinical atherosclerosis

Abstract: The indices of subclinical atherosclerosis, arterial stiffness and wave reflection, indicate different aspects of vascular status in otherwise healthy subjects.

Cited by 59 publications

References 27 publications

The Assessment of Finger Photoplethysmography Fitness Index (PPGF) among Young Men with Cardiovascular Disease Risk Factors: A Cross Sectional Study

The Assessment of Finger Photoplethysmography Fitness Index (PPGF) among Young Men with Cardiovascular Disease Risk Factors: A Cross Sectional Study

Association between high arterial stiffness and left ventricular filling pressures in patients with acute myocardial infarction

Abdominal obesity and low-grade systemic inflammation as markers of subclinical organ damage in type 2 diabetes

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