Arterial Stiffness in Patients with Non-Diabetic Chronic Kidney Disease (CKD)

Matsuda, Nami; Takei, Takashi; Fujiu, Ayuko; Ogawa, Tetsuya; Nitta, Kosaku

doi:10.5551/jat.e602

Cited by 28 publications

(17 citation statements)

References 29 publications

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“…39,40 Similar correlation was identified between PWV with age, eGFR, CSBP, CPP were found in our results consistent with these previous studies. Wang et al 41 showed that SBP, eGFR were the major determinants of arterial stiffness.…”

Section: Discussionsupporting

confidence: 92%

Assessment of volume status and arterial stiffness in chronic kidney disease

et al. 2013

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Aim: There is limited information about arterial stiffness in chronic kidney disease (CKD) which is an independent risk factor for cardiovascular events. Pulse wave velocity (PWV), augmentation index (AIx) are using to determine arterial stiffness. We aimed to study PWV, AIx, volume status in patients with stage 3B-5 CKD and continuous ambulatory peritoneal dialysis (CAPD). Methods: Sixty-six stage 3B-5 CKD patients, 21 CAPD patients, 34 healthy controls were included. Pulse wave velocity, AIx, volume status was evaluated by Mobil-O-Graph Õ , and bioimpedance spectroscopy, respectively. Results: The Median PWV was 7.5 m/s in CKD, 6.2 m/s in CAPD, 5.9 m/s in healthy controls, and while PWV was found to have increased significantly in CKD patients (p ¼ 0.002), the Alx values were similar in all groups. The median extracellular fluid excess was higher in both the CKD and, CAPD patients when compared with healthy controls (1.26 and 1.21 L, respectively). Overhydration was more prevalent in CKD and CAPD patients (p50.001). Age, central systolic blood pressure, body mass index, fat mass, overhydration, CKD, eGFR were the major determinants of PWV. Conclusion: Increased PWV was found in stage 3B-5 CKD patients. Overhydration may contribute this increment.

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Section: Discussionsupporting

confidence: 92%

Assessment of volume status and arterial stiffness in chronic kidney disease

et al. 2013

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“…A growing body of evidence has been accumulated that CKD constitutes a critical determinant of 19) . This clinically important issue has been focused on intensively because of the recently wellrecognized topic, i.e., cardio-renal continuum 20) .…”

Section: Discussionmentioning

confidence: 99%

Brachial-Ankle Pulse Wave Velocity Predicts Silent Cerebrovascular Diseases in Patients with End-Stage Renal Diseases

Washida

Wakino

Hayashi

et al. 2010

JAT

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Aim: Cerebrovascular disease (CVD) is a major determinant of the prognosis in end-stage renal diseases (ESRD). The purpose of this study was to examine whether factors associated with arterial stiffness contributed to the development of CVD in patients with ESRD. Methods: CVD (lacunes and carotid/intracranial artery stenosis) was evaluated with brain magnetic resonance imaging (MRI), and carotid/intracranial artery magnetic resonance angiography (MRA) in 44 pre-dialytic patients. The severity of CVD was evaluated by the number of lacunes and the degree of stenosis, respectively. The association between CVD and atherosclerotic parameters was evaluated. Results: Patients with severe lacunes (n 18) manifested older age, lower diastolic blood pressure, serum creatinine and albumin, and higher CRP and serum calcium than those with absent-moderate lacunes (n 26). When assessed by multivariate analysis, only baPWV was adopted as an independent risk factor for severe lacunes. Furthermore, baPWV and i-PTH were associated with the severity of carotid/intracranial artery stenosis, both of which were independent of other risk factors, including age and diabetes. Conclusions: Arterial stiffness may constitute a novel determinant predicting the severity of CVD in pre-dialytic patients besides classical risk factors. J Atheroscler Thromb, 2010; 17:165-172.

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“…Details of the methodology have been described elswhere 10) . Occlusion and monitoring cuffs were placed snugly around all four limbs with the patient in the supine position, and the pressure waveforms of the brachial and tibial arteries were recorded with an automatic waveform analyzer after 15 min of bed rest.…”

Section: Measurement Of Pwvmentioning

confidence: 99%

Comparison of Serum Albumin, Serum C-Reactive Protein, and Pulse Wave Velocity as Predictors of the 4-Year Mortality of Chronic Hemodialysis Patients

Amemiya

Ogawa

Otsuka

et al. 2011

JAT

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Aim:Although serum albumin and C-reactive protein (CRP) levels and pulse wave velocity (PWV) are known to be associated with the clinical outcome of hemodialysis (HD) patients, it is unknown which of these parameters are more predictive of the long-term mortality of such patients. Methods: We measured biochemical parameters, including serum albumin and CRP, and the PWV of 202 patients on maintenance HD therapy and followed their course for 4 years, and 186 of the patients were enrolled in the current study analyses. We divided the 186 patients into three tertiles according to their serum albumin and CRP levels and PWV values, and conducted multivariate analyses to examine the impact of the tertiles on 4-year mortality. Results: Twenty-three (12.4%) patients died during the follow-up period, and the serum albumin of the group that died was significantly lower than in the group that survived, but the CRP levels and PWV were significantly higher in the group that died. The results of Kaplan-Meier analyses revealed a significantly higher risk of all-cause mortality in HD patients with higher CRP based on the results of Cox proportional hazards analyses; however, the serum albumin and PWV values were not associated with all-cause mortality. Conclusion:The results of this study suggest that serum CRP levels are a better mortality predictor than serum albumin or PWV values of chronic HD patients.

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Arterial Stiffness in Patients with Non-Diabetic Chronic Kidney Disease (CKD)

Cited by 28 publications

References 29 publications

Assessment of volume status and arterial stiffness in chronic kidney disease

Assessment of volume status and arterial stiffness in chronic kidney disease

Brachial-Ankle Pulse Wave Velocity Predicts Silent Cerebrovascular Diseases in Patients with End-Stage Renal Diseases

Comparison of Serum Albumin, Serum C-Reactive Protein, and Pulse Wave Velocity as Predictors of the 4-Year Mortality of Chronic Hemodialysis Patients

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