Arterial stiffness in children and adolescents with masked and sustained hypertension

Kollios, Konstantinos; Nika, Thomaitsa; Kotsis, Vasilios; Chrysaidou, Katerina; Antza, Christina; Stabouli, Stella

doi:10.1038/s41371-020-0318-4

Cited by 27 publications

(26 citation statements)

References 33 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…This finding should be checked in larger series. On the other hand, we may consider that PWV determined along with ABPM by the same device may be beneficial in children with CSK.Stiffening of arteries leads to increased cBP, which indicates increased LVH and associated comorbidities such as arrhythmias 7,11,37,40. Despite increased PWV and cBP levels in patients with CSK, we did not observe any increase in LVMI or tendency for ventricular arrhythmia or sudden cardiac death.…”

mentioning

confidence: 63%

Cardiovascular risk assessment in children and adolescents with congenital solitary kidneys

Kasap-Demir¹,

Soyaltın²,

Alparslan³

et al. 2021

J of Clinical Hypertension

View full text Add to dashboard Cite

It is well known that patients with solitary kidneys (SKs) are at risk of hypertension (HT), proteinuria, and glomerulosclerosis due to their low number of nephrons. 1-4 They tend to have higher levels of HT-associated end-organ damage markers, such as left ventricular mass index (LVMI) and microalbuminuria. 5 Congenital SKs (CSKs) or acquired SKs (ASKs) have different effects on glomerular filtration rate (GFR) and blood pressure (BP).

show abstract

mentioning

confidence: 63%

Cardiovascular risk assessment in children and adolescents with congenital solitary kidneys

Kasap-Demir¹,

Soyaltın²,

Alparslan³

et al. 2021

J of Clinical Hypertension

View full text Add to dashboard Cite

show abstract

“…Age range of participants was 4-25 years (reported in 11 studies), 50% were male and 30% had elevated BP. Five (38.5%) studies employed indirect method to measure cfPWV (brachial oscillometry with transfer function) [21,22,[24][25][26]. Two (15%) studies used z scores to report cfPWV, the mean of which was over 99th percentile in children with hypertension [23,25].…”

Section: Carotid-femoral Pulse Wave Velocitymentioning

confidence: 99%

Disparities between determinants of impaired vascular structure and function in young people with primary hypertension: a systematic review

Ažukaitis

Sinha

Obrycki

et al. 2022

Journal of Hypertension

View full text Add to dashboard Cite

Objective: Early effects of primary hypertension on arterial structure and function in children and young people (CYP) and their determinants remain elusive. We aimed to review independent determinants of carotid intima-media thickness (cIMT), carotid wall cross-sectional area (WCSA) and carotid-femoral pulse wave velocity (cfPWV) in CYP with primary hypertension.Methods: We performed a systematic review of studies reporting multivariable analysis of cfPWV, cIMT and WCSA in CYP (up to 25 years of age) with primary hypertension. Literature search was performed in PubMed database and 13, 12 and two articles including 3860 (age range 4-25 years, 50% male individuals), 2038 children (5-25 years, 55% male individuals) and 136 children (5-17 years, 85% male individuals) were selected for final analysis of cfPWV, cIMT and WCSA, respectively.Results: Ninety and 86% of the studies reported higher cfPWV and cIMT in CYP with elevated blood pressure (BP) compared with normotensive controls. Different indices of BP were positively associated with cfPWV in 92% of studies, whereas BMI showed association in 31%. Carotid IMT associated with BP indices in 50% and with BMI in 25% of the studies. WCSA was studied longitudinally and its improvement associated with decrease in measures of central obesity. Conclusion:We found a disparity between the determinants of structural and functional impairment of arterial tree in CYP with primary hypertension. In contrast to cIMT and WCSA, increase of cfPWV is almost exclusively determined by BP.

show abstract

“…BP readings were obtained every 15 min during daytime and every 20 minutes during night-time. Fitting the monitor, reading and analysing the ambulatory BP data has been previously described [23][24][25]. ABPM sessions with 75% valid BP measurements were included in the study [26].…”

Section: Blood Pressure Measurementsmentioning

confidence: 99%

Blood pressure and glomerular filtration rate in youth with tuberous sclerosis complex

et al. 2022

Self Cite

View full text Add to dashboard Cite

BackgroundRenal involvement is very common in tuberous sclerosis complex (TSC) and is characterised by the development of angiomyolipoma and cysts. The aims of the present study were to assess kidney function and clinical features of renal involvement in TSC, including kidney function, and blood pressure (BP) levels in children, adolescents and young adults. MethodsNon-selected patients with a de nite diagnosis of TSC attending the paediatric neurology outpatient department of a tertiary hospital were included in a cross-sectional study. All participants had a renal imaging study within 6 months of ambulatory blood pressure (BP) and glomerular ltration rate (GFR) assessment. Data on demographics, history, genotype, kidney function at diagnosis and last imaging were collected. ResultsThe median age of the patients was 15 years (IQR range 9 to18). 23.5% of the participants had ambulatory BP hypertension. Systolic BP levels correlated signi cantly with GFR DTPA values despite the absence of hyper ltration. Greater increase in GFR from initial TSC diagnosis till the age of the assessment, resulted in higher GFR levels in childhood and adolescence in those that developed hypertension and possibly in those with angiomyolipoma or cysts. All patients with ambulatory BP hypertension had angiomyolipomas or cysts on renal imaging studies. ConclusionsHypertension may present with increased frequency in young patients with kidney disease associated with TSC. Routine ambulatory BP measurement could be part of the annual clinical assessment in patients with TSC. What Is KnownNearly half of the patients with TSC have a premature decline in their renal function in their fth decade of life Hypertension and hyper ltration have been proposed as modi able factors of progression of renal decline

show abstract

Arterial stiffness in children and adolescents with masked and sustained hypertension

Cited by 27 publications

References 33 publications

Cardiovascular risk assessment in children and adolescents with congenital solitary kidneys

Cardiovascular risk assessment in children and adolescents with congenital solitary kidneys

Disparities between determinants of impaired vascular structure and function in young people with primary hypertension: a systematic review

Blood pressure and glomerular filtration rate in youth with tuberous sclerosis complex

Contact Info

Product

Resources

About