Arterial stiffness contributes to coronary artery disease risk prediction beyond the traditional risk score (RAMA-EGAT score)

Yingchoncharoen, Teerapat; Limpijankit, Thosaphol; Jongjirasiri, Sutipong; Laothamatas, Jiraporn; Yamwong, Sukit; Sritara, Piyamitr

doi:10.1136/heartasia-2011-010079

Cited by 59 publications

(59 citation statements)

References 49 publications

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“…Several researchers reported that CAVI was high in patients with CAD [31,32,33]. Yingchoncharoen et al [34] reported that the traditional risk score (RAMA-EGAT) has been shown to be an accurate scoring system for predicting CAD. Furthermore, they reported that the addition of CAVI to the RAMA-EGAT score significantly improves the diagnostic yield of CAD.…”

Section: Cavi As a Surrogate Marker Of Arteriosclerotic Diseasesmentioning

confidence: 99%

The Role of Monitoring Arterial Stiffness with Cardio-Ankle Vascular Index in the Control of Lifestyle-Related Diseases

Shirai

Saiki²,

Nagayama³

et al. 2015

Pulse

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Arteriosclerosis is a major contributor to cardiovascular diseases. One of the difficulties in controlling those diseases is the lack of a suitable indicator of arteriosclerosis or arterial injury in routine clinical practice. Arterial stiffness was supposed to be one of the monitoring indexes of arteriosclerosis. Cardio-ankle vascular index (CAVI) is reflecting the stiffness of the arterial tree from the origin of the aorta to the ankle, and one of the features of CAVI is independency from blood pressure at a measuring time. When doxazosin, an α₁-adrenergic blocker, was administered, CAVI decreased, indicating that arterial stiffness is composed of both organic stiffness and functional stiffness, which reflects the contraction of arterial smooth muscle. CAVI shows a high value with aging and in many arteriosclerotic diseases, and is also high in persons possessing main coronary risk factors such as diabetes mellitus, metabolic syndrome, hypertension and smoking. Furthermore, when the most of those risk factors were controlled by proper methods, CAVI improved. Furthermore, the co-relationship between CAVI and heart function was demonstrated during treatment of heart failure. This paper reviews the principle and rationale of CAVI, and discusses the meaning of monitoring CAVI in following up so-called lifestyle-related diseases and cardiac dysfunction in routine clinical practice.

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Section: Cavi As a Surrogate Marker Of Arteriosclerotic Diseasesmentioning

confidence: 99%

The Role of Monitoring Arterial Stiffness with Cardio-Ankle Vascular Index in the Control of Lifestyle-Related Diseases

Shirai

Saiki²,

Nagayama³

et al. 2015

Pulse

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“…Several researchers reported that CAVI was high in patients with CAD 20,22,23) . Yingchoncharoen et al 24) reported that the traditional .…”

Section: Arteriosclerotic Diseases (A) Cadmentioning

confidence: 99%

The Role of a Novel Arterial Stiffness Parameter, Cardio-Ankle Vascular Index (CAVI), as a Surrogate Marker for Cardiovascular Diseases

Saiki

Sato

Watanabe

et al. 2016

J Atheroscler Thromb

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Measurement of arterial stiffness in routine medical practice is important to assess the progression of arteriosclerosis. So far, many parameters have been proposed to quantitatively represent arterial stiffness. Among these, pulse wave velocity (PWV) has been most frequently applied to clinical medicine because those could be measured simply and non-invasively. PWV had established the usefulness of measuring arterial wall stiffness. However, PWV essentially depends on blood pressure at the time of measurement. Therefore, PWV is not appropriate as a parameter for the evaluation of arterial stiffness, particularly for the studies involving blood pressure changes.On the other hand, stiffness parameter is an index reflecting arterial stiffness without the influence of blood pressure. Recently, this parameter has been applied to develop a new arterial stiffness index called cardio-ankle vascular index (CAVI). Therefore, CAVI does not depend on blood pressure changes during the measurements; CAVI could represent the stiffness of the arterial tree from the origin of the aorta to the ankle.Many clinical studies obtained from CAVI are being accumulated. CAVI showed high value in arteriosclerotic diseases, such as coronary artery diseases, cerebral infarction, and chronic kidney diseases, and also in majority of people with various coronary risk factors. The improvement of those risk factors decreased CAVI. Furthermore, the role of CAVI as a predictor of cardio-vascular events was reported recently.We review the clinical studies on CAVI and discuss the clinical usefulness of CAVI as a candidate surrogate end-point marker for cardiovascular disease.

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“…Действительно, при изучении СЛСИ у больных ИБС достаточно убедительно показана его связь с рас-пространенностью коронарного атеросклероза [3,10,11]. Так, у больных сахарным диабетом 2-го типа СЛСИ позитивно коррелировал с кальциевым индек-сом коронарных артерий, определяемым при мульти-спиральной компьютерной томографии (r=0,303, p<0,0001) [10].…”

Section: Discussionunclassified

“…Так, у больных сахарным диабетом 2-го типа СЛСИ позитивно коррелировал с кальциевым индек-сом коронарных артерий, определяемым при мульти-спиральной компьютерной томографии (r=0,303, p<0,0001) [10]. Также есть свидетельства о наличии связи между СЛСИ и распространенностью [11] и выраженностью коронарного атеросклероза [6,9,12,13]. Так, при отсутствии стенозов КА СЛСИ составил 8,34±1,01, при стенозах одной, двух и трех КА -8,44±1,39; 9,95±1,22 и 10,12±1,56, соответственно, (р<0,05) [9].…”

Section: Discussionunclassified

Cardiac-Ankle Vessel Index and Short Term Results of Coronary Bypass Grafting in Coronary Heart Disease

Сумин¹,

Щеглова²,

Осокина³

et al. 2015

Russ J Cardiol

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Цель. Изучить взаимосвязь значений сердечно-лодыжечного сосудистого индекса (СЛСИ) и результатов коронарного шунтирования у больных ИБС. Материал и методы. 356 пациентов, подвергшихся КШ, были разделены на 2 группы в зависимости от значения СЛСИ: I группа -СЛСИ ≥9,0 (n=231), II группа -СЛСИ <9,0 (n=125). За контрольные точки в течение года после КШ принимались летальный исход, инфаркт миокарда (ИМ), острое нарушение мозго-вого кровообращения (ОНМК), транзиторная ишемическая атака (ТИА), нарушения ритма, развитие синдрома полиорганной недостаточности (СПОН), а также их комбинация. Дополнительно проведен анализ влияния различных дооперацион-ных и периоперационных факторов на развитие вышеперечисленных событий. Результаты. У больных с нормальным СЛСИ чаще встречалось однососудис-тое поражение коронарных артерий и шунтирование одной коронарной арте-рии, чем у больных с патологическим СЛСИ. Группы достоверно не различа-лись по количеству наложенных шунтов, длительности искусственного крово-обращения, частоте проведения сочетанных операций. Выявлено, что наличие патологического СЛСИ у больных ИБС негативно влияет на непосредственные результаты коронарного шунтирования. У таких пациентов было больше пери-операционных осложнений коронарного шунтирования, в том числе, инсуль-тов и летальных исходов (р=0,05 и р=0,02, соответственно). Заключение. У больных ИБС при выполнении операций коронарного шунтиро-вания патологический СЛСИ (>9,0) выявлен в 35% случаев. Больные ИБС с высо-кими значениями СЛСИ были старше, у них чаще выявляли артериальную гипер-тензию, сахарный диабет и поражение некоронарных артериальных бассейнов. Наличие патологического СЛСИ было ассоциировано с большей частотой перио-перационных осложнений КШ, в частности, летальных исходов и инсультов. CARDIAC-ANKLE VESSEL INDEX AND SHORT TERM RESULTS OF CORONARY BYPASS GRAFTING IN CORONARY HEART DISEASESumin A. N., Shcheglova A. V., Osokina A. V., Fedorova N. V., Zhuchkova E. A., Barbarash O. L.Aim. To study the relationship of cardiac-ankle vessel index (CAVI) and the results of coronary bypass grafting in CHD. Material and methods. 356 patients after CABG were selected into two groups according to CAVI: 1st group -CAVI≥9,0 (n=231), 2nd group -CAVI<9,0 (n=125). As end points after CABG in 1 year we used death, myocardial infarction (MI), acute cerebrovascular accident (CVA), transitory ischemic attack (TIA), rhythm disorders, polyorganic dysfunction syndrome development (PDS) and combination of these. Additionally the analysis performed to analyse the influence of various pre-and perioperational factors on the development of the endpoints. Results. In patients with normal CAVI there was more prevalent one-vessel diseases and bypass to one artery, compared to those with pathological CAVI. Groups did not show a significant difference in the quantity of shunts, duration of artificial circulation, and quantity of operations. It was revealed that the presence of pathological CAVI in CHD patients does negatively influence the short-term results of the operation. In t...

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Arterial stiffness contributes to coronary artery disease risk prediction beyond the traditional risk score (RAMA-EGAT score)

Cited by 59 publications

References 49 publications

The Role of Monitoring Arterial Stiffness with Cardio-Ankle Vascular Index in the Control of Lifestyle-Related Diseases

The Role of Monitoring Arterial Stiffness with Cardio-Ankle Vascular Index in the Control of Lifestyle-Related Diseases

The Role of a Novel Arterial Stiffness Parameter, Cardio-Ankle Vascular Index (CAVI), as a Surrogate Marker for Cardiovascular Diseases

Cardiac-Ankle Vessel Index and Short Term Results of Coronary Bypass Grafting in Coronary Heart Disease

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