Arterial stiffness as a cardiovascular events risk marker and possibilities for its downregulation by contemporary antihypertensive medications

Загидуллин, Н. Ш.; Zulkarneev, Rustem; Scherbakova, Elena; Safina, Yu F; Загидуллин, Ш. З.

doi:10.17816/kmj1847

Cited by 3 publications

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References 27 publications

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“…В целом, согласно данным исследований, дигидропиридиновые антагонисты кальция способны уменьшать жесткость артерий [67,68]. Точные механизмы их действия на данный параметр до конца не установлены.…”

Section: возможности периндоприла и амлодипина в снижении вадunclassified

Mechanisms for the Development of Blood Pressure Variability and the Potential of Antihypertensive Drugs in Their Correction

et al. 2019

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Blood pressure variability (BPV) is the fluctuations of blood pressure over a certain period of time under the influence of various factors. The issue of increased BPV is of particular clinical importance due to high predictive value of this parameter as a risk factor for fatal and non-fatal cardiovascular, cerebrovascular and renal events. It is proved that in the BPV increasing, the key role is played by impairments in arterial baroreflexes, which, in turn, are mediated by increased vascular stiffness, impact of angiotensin II and the sympathetic nervous system, endothelial dysfunction, nitric oxide deficiency and aging, including the vascular aging. Antihypertensive drugs that targeting largest amount of pathophysiological mechanisms in BPV increasing have a most advantages in correcting excessive pressure fluctuations. In this regard such drugs are perindopril and amlodipine, which can eliminate almost the entire spectrum of increased BPV causes and, therefore, optimally reduce the cardiovascular risk.

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Section: возможности периндоприла и амлодипина в снижении вадunclassified

Mechanisms for the Development of Blood Pressure Variability and the Potential of Antihypertensive Drugs in Their Correction

et al. 2019

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Prevalence of Early Vascular Aging Syndrome in Men Working Under Noise Exposure

Rudoi

2024

Arhivʺ vnutrennej mediciny

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Noise can be one of the factors provoking the premature development of changes in the artery wall associated with age. Aim: to assess the stiffness of the vascular wall and the prevalence of early vascular aging syndrome in men of working age, depending on contact with noise, smoking status and the presence of hypertension. Materials and methods. 148 men worked in noise and 90 men for whom the level of all harmful production factors in the workplace did not exceed the permissible standards were examined. The average age of the examined patients was 41.6 ± 9.9 years, 133 people (55.9 %) were smokers, 43 people (18.1 %) were obese, 47 people (19.7 %) had a complicated heredity, 132 people (55.5 %) had hypercholesterolemia, and 37 people (15.5 %) suffered from arterial hypertension (AH). Each of the patients suffering from hypertension received antihypertensive therapy. There were no significant differences in the structure of antihypertensive therapy in the compared groups of patients. The groups of surveyed were comparable in age, body mass index, prevalence of smoking, obesity and hypertension. All patients underwent volumetric sphygmography according to the standard procedure in the morning on the VaSera 1500N device (FukudaDenshi, Japan), the device automatically determined the cardio-ankle vascular index on the right and left (R/L — CAVI), the estimated age of the arteries. The syndrome of early vascular aging (EVA syndrome) was considered to be a clinical condition associated with an excess of the estimated age of the arteries of the patient’s passport age by 4 years or more (VaSera criteria). Results and discussion. After exclusion of smokers and hypertensive patients from the analysis and correction for age, the vascular wall stiffness index on the right and left in the main group of patients significantly exceeded the indicated indicator in the comparison group. R — CAVI was 7.2 [6.9; 7.9] and 7.05 [6.05; 7.45], respectively, p=0.02; L — CAVI was 7.3 [7.0; 7.9] and 6.85 [6.05; 7.65], respectively, p =0.007. In the group of people working in noise, the estimated age of the arteries significantly exceeded the passport age (p=0.004), whereas in the control group these indicators were comparable (p=0.27). The prevalence of EVA syndrome in the main group of patients was 14 cases (27.5 %), which was 8.6 times higher than the prevalence of EVA syndrome in the comparison group — 1 case (3.2 %); p=0.004. The comparability of the patient groups according to the main cardiovascular risk factors and the exclusion criteria from the study suggested that the identified changes in the state of the vascular wall are associated with the effects of noise on the body of the examined. Conclusion. Noise can be a factor that accelerates vascular aging. It is necessary to monitor the state of the cardiovascular system in persons working in noise.

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The Potential of the Volumetric Sphygmography for the Diagnosis of Impaired Arterial Stiffness in Patients with Uncomplicated Arterial Hypertension and Its Possibilities for Evaluation of the Antihypertensive Therapy Effectiveness

Борисова¹,

Кочетков

Остроумова

2018

Racionalʹnaâ farmakoterapiâ v kardiologii

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Цель. Изучить параметры жесткости сосудистой стенки у пациентов среднего возраста с эссенциальной артериальной гипертонией (АГ) II стадии 1-2 степени и их динамики на фоне лечения фиксированными комбинациями (ФК) антигипертензивных препаратов (АГП). Материал и методы. На первом этапе исследования по данным историй болезни была сформирована группа пациентов с АГ II стадии 1-2 степени, не получавших АГП (n=100; средний возраст 51,9±6,5 лет), и сопоставимая с ними по полу группа здоровых людей с нормальным уровнем артериального давления (АД) (n=86; средний возраст 48,8±5,8 лет). Анализ показателей жесткости артерий проводили методом объемной сфигмографии на аппарате VaSera VS-1500N (Fukuda Denshi Co., Ltd, Япония). Всем обследуемым проводили суточное мониторирование АД (СМАД) (монитор БиПиЛаб Н BP2005-01.04.00.2540, Петр Телегин, Россия) и рутинное измерение АД по методу Короткова. На втором этапе исследования с учетом ретроспективных данных была сформирована группа больных АГ (n=90), у которых на фоне медикаментозной антигипертензивной терапии (ФК периндоприла аргинин/индапамид или валсартан/амлодипин) был достигнут целевой уровень АД по рутинному измерению (менее 140/90 мм рт.ст.), и у которых через 12 нед после достижения целевого АД была проведена оценка эффективности терапии (общеклинические данные, СМАД, объемная сфигмография). Результаты. На первом этапе исследования по данным объемной сфигмографии у пациентов с АГ сердечно-лодыжечный сосудистый индекс (сardio-ankle vascular index, CAVI) как слева (7,9±1,3), так и справа (8,1±1,3), а также индекс аугментации справа (1,22±0,31%) оказались статистически значимо выше (p=0,006; p=0,003; p=0,047, соответственно), чем у лиц контрольной группы (7,5±0,9; 7,6±0,9; 1,13±0,28%, соответственно). На втором этапе исследования на фоне лечения ФК АГП статистически значимо снизились CAVI как слева (до 7,36±1,37; p=0,02), так и справа (до 7,46±1,44; p=0,02). Заключение. У нелеченых пациентов 40-65 лет с АГ II стадии 1-2 степени согласно результатам объемной сфигмографии жестокость артерий статистически значимо выше по сравнению с сопоставимыми по полу здоровыми лицами. Антигипертензивная терапия (в течение 12 нед после достижения целевого АД) ФК АГП статистически значимо улучшает упруго-эластические свойства магистральных артерий, снижая величину CAVI.Ключевые слова: артериальная гипертония, жесткость артерий, сердечно-сосудистый риск, объемная сфигмография, сердечно-лодыжечный сосудистый индекс, фиксированные комбинации антигипертензивных препаратов.Для цитирования: Борисова Е.В., Кочетков А.И., Остроумова О.Д. Возможности метода объемной сфигмографии для выявления поражения сосудов у пациентов с неосложненной артериальной гипертонией и оценки эффективности антигипертензивной терапии. Рациональная Фармакотерапия в Кардиологии 2018;14(5):646-653.Aim. To investigate arterial stiffness parameters in middle-aged patients with stage II grade 1-2 essential arterial hypertension (HT) and evaluate their changes after treatment with single pill combinations (SPC) of antihypertensive ...

show abstract

Arterial stiffness as a cardiovascular events risk marker and possibilities for its downregulation by contemporary antihypertensive medications

Cited by 3 publications

References 27 publications

Mechanisms for the Development of Blood Pressure Variability and the Potential of Antihypertensive Drugs in Their Correction

Mechanisms for the Development of Blood Pressure Variability and the Potential of Antihypertensive Drugs in Their Correction

Prevalence of Early Vascular Aging Syndrome in Men Working Under Noise Exposure

The Potential of the Volumetric Sphygmography for the Diagnosis of Impaired Arterial Stiffness in Patients with Uncomplicated Arterial Hypertension and Its Possibilities for Evaluation of the Antihypertensive Therapy Effectiveness

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