2010
DOI: 10.1038/ajh.2010.99
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Arterial Stiffness and Wave Reflections in Marathon Runners

Abstract: A significant fall in wave reflections was observed after marathon race, whereas aortic stiffness was not altered. Moreover, marathon runners have increased aortic stiffness and pressures, whereas wave reflections indexes do not differ compared to controls.

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Cited by 117 publications
(147 citation statements)
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“…A study of 47 individuals who trained extensively for and competed in marathons found that pulse wave velocity and aortic stiffness were significantly higher in the group of marathoners compared with controls. 49 It is possible that the sustained shear stress caused by protracted endurance efforts eventually may induce fibrotic changes and decreases in arterial wall elasticity. Diastolic dysfunction of both the RV and LV has also been observed in individuals doing long-term extreme ET and racing.…”
Section: Biomarker Evidence For Cardiac Damage With Extreme Endurance Etmentioning
confidence: 99%
“…A study of 47 individuals who trained extensively for and competed in marathons found that pulse wave velocity and aortic stiffness were significantly higher in the group of marathoners compared with controls. 49 It is possible that the sustained shear stress caused by protracted endurance efforts eventually may induce fibrotic changes and decreases in arterial wall elasticity. Diastolic dysfunction of both the RV and LV has also been observed in individuals doing long-term extreme ET and racing.…”
Section: Biomarker Evidence For Cardiac Damage With Extreme Endurance Etmentioning
confidence: 99%
“…Twelve studies were identified and examined to determine whether normalizing AIx to HR influences the interpretation of the findings (Table 1). Eight studies reported significantly improved between-group/condition differences using the AIx@75 versus the AIx alone [23][24][25][26][27][28][29] , two studies reported no significant differences using the AIx but a significant difference using AIx@75 30,31) , one study reported a decrease in significance using the AIx@75 32) and one study reported a change in the direction of the effect 33) . Given these findings, careful interpretation of the physiological significance of normalization to HR is warranted.…”
Section: Validity Of the Aix And Influence Of Normalization To Hrmentioning
confidence: 98%
“…16 Following completion of a marathon, there are large reductions in pressure from wave reflections, aortic pulse pressure, and aortic diastolic pressure. 3 This is clinically relevant, as aortic diastolic pressure is a significant determinant of coronary perfusion pressure and subendocardial viability. Reduced central pulse pressure may be due to reduced forward wave genesis owing to reduced venous return and preload due to peripheral venous pooling.…”
mentioning
confidence: 99%
“…Thus, there appears to be a U curve with respect to exercise and vascular function. 3 Inactivity is detrimental, but excessive activity may be equally detrimental.…”
mentioning
confidence: 99%
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