Arterial Stiffness and Wave Reflections in Patients With Sickle Cell Disease

Lemogoum, Daniel; Bortel, Luc Van; Najem, Boutaïna; Dzudie, Anastase; Teutcha, C.; Madu, Ernest; Leeman, Marc; Degaute, Jean-Paul; Borne, Philippe van de

doi:10.1161/01.hyp.0000148506.73622.ba

Cited by 32 publications

(29 citation statements)

References 38 publications

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“…10 Some reports have observed a decreased AS in patients with SCD. 11 Because stiffness is influenced by arterial pressure, 12 we have expected that this parameter would be lower in our cohort (with lower blood pressure compared with control subjects); however, we found the opposite.…”

Section: Discussionmentioning

confidence: 63%

Arterial Stiffness and Stroke in Sickle Cell Disease

Bélizna

Loufrani

Ghali

et al. 2012

Stroke

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Background and Purpose-Large vessels are also affected in sickle cell disease. The aim of this study was to assess several parameters in adult patients with sickle cell disease compared with control subjects and in patients with sickle cell disease with stroke. Methods-Carotid arterial stiffness, intima-media thickness, and transcranial Doppler ultrasonography were measured. Results-Arterial stiffness and transcranial Doppler velocity were significantly increased in 49 patients with sickle cell disease compared with 47 control subjects (PϽ0.05) and especially in patients with stroke (PϽ0.05). Conclusions-These data suggest that transcranial Doppler and arterial stiffness might be associated to stroke in adult patients with sickle cell disease.

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Section: Discussionmentioning

confidence: 63%

Arterial Stiffness and Stroke in Sickle Cell Disease

Bélizna

Loufrani

Ghali

et al. 2012

Stroke

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“…20 In our hands (D.L. ), the meanϮSD intraobserver repeatability of aortic PWV measurements with ComplioR device expressed as coefficient of variation was 3.6Ϯ1.5% (nϭ30).…”

Section: Carotid-femoral Pwvmentioning

confidence: 67%

“…20 All of the measurements were performed by the same investigator (D.L.) in triplicate and averaged for analysis.…”

Section: Hemodynamic Measurementsmentioning

confidence: 99%

Effects of Hunter-Gatherer Subsistence Mode on Arterial Distensibility in Cameroonian Pygmies

et al. 2012

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Abstract-We aimed to assess whether arterial distensibility estimated by pulse wave velocity (PWV) and augmentation index (AI) differs between Cameroon traditional pygmies (TPs) on hunter-gather subsistence mode, contemporary pygmies who migrated to semiurban area, and the Bantou farmers (BFs) sharing the same environment. For that purpose, we recorded carotid-femoral PWV (ComplioR) in age and sex carefully matched 20 TPs, 20 contemporary pygmies, and 22 BFs. Aortic AI corrected for heart rate and blood pressures were generated from pressure wave analysis (SphygmoCor). Lipid profile was determined in TP and BF participants. TPs were shorter (Pϭ0.02) with lower body weight (PϽ0.01) in comparison with contemporary pygmies and BFs. TPs had lower low-density lipoprotein cholesterol but higher high-density lipoprotein cholesterol than BFs (PϽ0.01). Their PWV (5.81Ϯ0.21 m/s) was slower (Pϭ0.006) than that of contemporary pygmies (6.82Ϯ0.36 m/s) or BFs (6.93Ϯ0.29 m/s); however, after its adjustment for age, mean arterial pressure, and heart rate, the difference was slightly attenuated (Pϭ0.051). PWV adjusted for weight did not differ between groups (Pϭ0.10). In the whole study population but not in TPs taken separately, multivariate regression analysis revealed that PWV was independently associated with mean arterial pressure, age, and TP status (PϽ0.001), whereas age, mean arterial pressure, and height emerged as independent determinants of aortic AI corrected for heart rate (PϽ0.001). Aortic AI corrected for heart rate did not differ in the 3 groups. In conclusion, hunter-gather lifestyle is associated with low atherosclerosis risk translated by lower aortic stiffness attributed at least partly to low weight and blunted effects of aging and blood pressures on TP arterial structure and function. 1-3 CVDs have been reported to be more frequent and severe in blacks.3,4 The underlying mechanisms remain unclear. The contributing role of genetics 4 and lifestyle 3,5 has been evoked. Although the genetic patterns remain poorly explored, available evidence points out the contributing role of changing living conditions and dietary patterns. 5,6 The influence of lifestyle on the global burden of CVD has been well established, 6,7 as well as the impact of dietary intervention on the reduction of cardiovascular (CV) risk. 8In Sub-Saharan Africa, hunter-gatherers have begun to shift toward an agriculture-based lifestyle over the last 5000 years. Only a few populations still base their mode of subsistence on hunting and gathering. The Pygmies are considered to be the largest group of mobile hunter-gatherers of Africa. They dwell in equatorial forests and are characterized by their short mean stature. However, little is known about their CV status.Few available studies indicated that, in Sub-Saharan Africa, communities like the Kalahari Bushmen and traditional pygmies (TPs) living with ancient lifestyle are relatively free of CVD, 9-11 partly attributed either to low level of blood pressure (BP) 9,10 and to their hunter-gatherer su...

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“…5,12,13 Endothelial injury may also trigger chronic degenerative manifestations through ischemic events and functional vascular remodeling observed in mice [18][19][20] and humans. 10,11,[21][22][23][24] Cell-free Hb and erythrocyte microparticle (MP) levels were recently found to correlate with hemolysis, oxygen saturation, pulmonary systolic pressure, and mortality in SCD patients. 13 In mice, Hb and heme may contribute to vascular injury and blood stasis via the activation of Toll-like receptor-4 (TLR-4), nuclear factor kB signaling, von Willebrand factor release in endothelial cells, 25,26 and the release of DNA by neutrophils.…”

Section: Introductionmentioning

confidence: 99%

Circulating cell membrane microparticles transfer heme to endothelial cells and trigger vasoocclusions in sickle cell disease

Camus

Moraes

Bonnin

et al. 2015

Blood

212

271

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International audienceIntravascular hemolysis describes the relocalization of heme and hemoglobin (Hb) from erythrocytes to plasma. We investigated the concept that erythrocyte membrane microparticles (MPs) concentrate cell-free heme in human hemolytic diseases, and that hemeladen MPs have a physiopathological impact. Up to one-third of cell-free heme in plasma from 47 patients with sickle cell disease (SCD) was sequestered in circulating MPs. Erythrocyte vesiculation in vitro produced MPs loaded with heme. In silico analysis predicted that externalized phosphatidylserine (PS) in MPs may associate with and help retain heme at the cell surface. Immunohistology identified Hb-laden MPs adherent to capillary endothelium in kidney biopsies from hyperalbuminuric SCD patients. In addition, heme-laden erythrocyte MPs adhered and transferred heme to cultured endothelial cells, inducing oxidative stress and apoptosis. In transgenic SAD mice, infusion of hemeladen MPs triggered rapid vasoocclusions in kidneys and compromised microvascular dilation ex vivo. These vascular effects were largely blocked by heme-scavenging hemopexin and by the PS antagonist annexin-a5, in vitro and in vivo. Adversely remodeled MPs carrying heme may thus be a source of oxidant stress for the endothelium, linking hemolysis to vascular injury. This pathway might provide new targets for the therapeutic preservation of vascular function in SCD

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Arterial Stiffness and Wave Reflections in Patients With Sickle Cell Disease

Cited by 32 publications

References 38 publications

Arterial Stiffness and Stroke in Sickle Cell Disease

Arterial Stiffness and Stroke in Sickle Cell Disease

Effects of Hunter-Gatherer Subsistence Mode on Arterial Distensibility in Cameroonian Pygmies

Circulating cell membrane microparticles transfer heme to endothelial cells and trigger vasoocclusions in sickle cell disease

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