Arterial stiffness and novel biomarkers in patients with abdominal aortic aneurysms

Kadoglou, Nikolaos P.E.; Papadakis, Ioannis; Moulakakis, Konstantinos G.; Ikonomidis, Ignatios; Alepaki, Maria; Moustardas, Petros; Lampropoulos, Stylianos; Karakitsos, Petros; Lekakis, John; Liapis, Christos D.

doi:10.1016/j.regpep.2012.08.014

Cited by 59 publications

(80 citation statements)

References 36 publications

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“…Knockdown of OPN reduces the inflammatory response in a murine model [24]. Clinically, OPN level is associated with inflammation in patients with ulcerative colitis [25], atherosclerosis [8], Crohn's disease [26], aortic abdominal aneurysms [27]. Overall, we propose that OPN contributes to increased mastitis and represents a novel target to antagonize these pathologies.…”

Section: Discussionmentioning

confidence: 85%

LPS induces pro-inflammatory response in mastitis mice and mammary epithelial cells: Possible involvement of NF-κB signaling and OPN

Xiao

Wang

Liu

et al. 2015

Pathologie Biologie

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Section: Discussionmentioning

confidence: 85%

LPS induces pro-inflammatory response in mastitis mice and mammary epithelial cells: Possible involvement of NF-κB signaling and OPN

Xiao

Wang

Liu

et al. 2015

Pathologie Biologie

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“…Using the same methods, Ganten et al [13] found a mean distensibility of (1.3 ± 0.8) × 10 -5 Pa −1 and (0.6 ± 0.5) × 10 −5 Pa −1 for two same locations in a AAA group of (68 ± 9)-year-old nonobese subjects. Using different ultrasound methods in AAA sac level, Kadoglou et al [24] found a mean PWV of (12.99 ± 3.75) m·s −1 in 108 AAA patients of BMI = (28.98 ± 4.23) kg/m 2 , and Li et al [25] found a mean PWV of (10.54 ± 6.52) m·s −1 in 8 AAA subjects without obesity. By comparing the absolute values derived from our study and that from previous publication, we found that the distensibility D (or PWV) was significantly lower (or higher) in our study.…”

Section: Discussionmentioning

confidence: 99%

Quantitative Aortic Distensibility Measurement Using CT in Patients with Abdominal Aortic Aneurysm: Reproducibility and Clinical Relevance

Zha

Peng

et al. 2017

BioMed Research International

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Purpose. To investigate the reproducibility of aortic distensibility (D) measurement using CT and assess its clinical relevance in patients with infrarenal abdominal aortic aneurysm (AAA). Methods. 54 patients with infrarenal abdominal aortic aneurysm were studied to determine their distensibility by using 64-MDCT. Aortic cross-sectional area changes were determined at two positions of the aorta, immediately below the lowest renal artery (level 1.) and at the level of its maximal diameter (level 2.) by semiautomatic segmentation. Measurement reproducibility was assessed using intraclass correlation coefficient (ICC) and Bland-Altman analyses. Stepwise multiple regression analysis was performed to assess linear associations between aortic D and anthropometric and biochemical parameters. Results. A mean distensibility of Dlevel 1. = (1.05 ± 0.22) × 10−5 Pa−1 and Dlevel 2. = (0.49 ± 0.18) × 10−5 Pa−1 was found. ICC proved excellent consistency between readers over two locations: 0.92 for intraobserver and 0.89 for interobserver difference in level 1. and 0.85 and 0.79 in level 2. Multivariate analysis of all these variables showed sac distensibility to be independently related (R2 = 0.68) to BMI, diastolic blood pressure, and AAA diameter. Conclusions. Aortic distensibility measurement in patients with AAA demonstrated high inter- and intraobserver agreement and may be valuable when choosing the optimal dimensions graft for AAA before endovascular aneurysm repair.

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“…25 Prior study reported that serum IL-10 levels were downregulated in patients with AAA. 26 TGF-β promotes Tregs differentiation and Foxp3 expression and has a beneficial role in inhibiting inflammatory response and preserving SMCs, leading to a relatively intact ECM. 16 In this study, the expression levels of IL-10 and TGF-β were increased after Tregs treatment both in vitro and in vivo.…”

Section: Discussionmentioning

confidence: 99%

Regulatory T Cells Prevent Angiotensin II–Induced Abdominal Aortic Aneurysm in Apolipoprotein E Knockout Mice

et al. 2014

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To test the hypothesis that adoptive transfer of regulatory T cells (Tregs) may dose-dependently inhibit the formation of angiotensin II–induced abdominal aortic aneurysm in apolipoprotein E knockout mice, we established an animal model of abdominal aortic aneurysm by angiotensin II infusion in apolipoprotein E knockout mice. Then mice received different treatment with PBS, low-dose Tregs, high-dose Tregs, or CD25-depleting PC61 antibody. Histopathologic analysis showed that the incidence of abdominal aortic aneurysm was 80%, 76%, 27%, and 71% in the PBS, low-dose Tregs, high-dose Tregs, and PC61 groups, respectively. Tregs treatment markedly decreased macrophage and CD4 + T-cell infiltration and preserved the medial smooth muscle cells. Furthermore, Tregs decreased the levels of proinflammatory cytokines, matrix metalloproteinase-2 (MMP-2) and MMP-9, increased the expression of anti-inflammatory interleukin-10 and transforming growth factor-β, and suppressed apoptosis and oxidative stress. In vitro, Tregs inhibited the response of human aortic smooth muscle cells to angiotensin II and reduced the expression of proinflammatory cytokines, MMP-2 and MMP-9, possibly by inhibiting the activation of nuclear factor-κB and extracellular signal-regulate kinase 1/2. In addition, Tregs downregulated macrophage type 1–related genes and upregulated macrophage type 2–related genes. However, Tregs-mediated effects were largely reversed by disrupting cell–cell contact or using neutralizing antibodies against interleukin-10 and transforming growth factor-β. Adoptive transfer of Tregs dose-dependently prevents angiotensin II–induced abdominal aortic aneurysm in apolipoprotein E knockout mice. The mechanisms may involve declined proinflammatory cytokine expression and MMP-2 and MMP-9 levels and enhanced anti-inflammatory cytokine expression, which is mediated by direct cell–cell contact and soluble mediators.

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Arterial stiffness and novel biomarkers in patients with abdominal aortic aneurysms

Cited by 59 publications

References 36 publications

LPS induces pro-inflammatory response in mastitis mice and mammary epithelial cells: Possible involvement of NF-κB signaling and OPN

LPS induces pro-inflammatory response in mastitis mice and mammary epithelial cells: Possible involvement of NF-κB signaling and OPN

Quantitative Aortic Distensibility Measurement Using CT in Patients with Abdominal Aortic Aneurysm: Reproducibility and Clinical Relevance

Regulatory T Cells Prevent Angiotensin II–Induced Abdominal Aortic Aneurysm in Apolipoprotein E Knockout Mice

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