Arterial Spin Labeling Perfusion of the Brain: Emerging Clinical Applications

Haller, Sven; Zaharchuk, Greg; Thomas, David L.; Lövblad, Karl-Olof; Barkhof, Frederik; Golay, Xavier

doi:10.1148/radiol.2016150789

Cited by 377 publications

(284 citation statements)

References 140 publications

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“…by using the spin labeling of water in arterial blood (19). The initial application the 3D ASL in the present study demonstrated numerous clinical advantages compared with the DSC-PWI exogenous contrast perfusion.…”

Section: Discussionmentioning

confidence: 99%

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Three-dimensional arterial spin labeling imaging and dynamic susceptibility contrast perfusion-weighted imaging value in diagnosing glioma grade prior to surgery

Wang

et al. 2017

Experimental and Therapeutic Medicine

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The current study aimed to investigate whole-brain three-dimensional arterial spin labeling imaging (3D ASL) and dynamic susceptibility contrast perfusion-weighted imaging (DSC-PWI), in regards to their diagnostic value of preoperative glioma grade. The parameter values obtained after correction will be correlated with the diagnostic value of 3D ASL and DSC-PWI perfusion. In the current study, 50 patients with gliomas confirmed by pathology were used, including 27 low-grade gliomas (LGGs) and 23 high-grade gliomas (HGGs). Prior to surgery all patients underwent 3 Tesla magnetic resonance imaging (MRI), 3D ASL, DSC-PWI and conventional enhanced MRI scans to obtain original 3D ASL and DSC-PWI images, and the tumor regions with the most obvious parenchyma perfusion and contralateral normal white matter were selected. In these areas, the ASL-relative cerebral blood flow (ASL-rCBF), DSC-relative cerebral blood flow (DSC-rCBF) and DSC-relative cerebral blood volume (DSC-rCBV) parameter values were then obtained after correction for individual differences. The results of the present study show that ASL-CBF, DSC-CBF, DSC-CBV values and ASL-rCBF, DSC-rCBF, DSC-rCBV values increased as the grade of the glioma being imaged increased, and there was a marked difference between the HGGs and the LGGs. ASL-rCBF was significantly positively correlated with DSC-rCBF (r=0.580, P<0.01). In addition, ASL-rCBF was significantly positively correlated with DSC-rCBV (r=0.431, P<0.01). Receiver operating characteristic (ROC) curves were applied to compare the two perfusion parameters of DSC-PWI and 3D ASL in the diagnosis of glioma grade. ASL-rCBF had the highest area value under the ROC curve (0.836). The areas under the ROC curve of DSC-rCBF and DSC-rCBV were analyzed using the Z test, but the difference was not statistically significant. When ASL-rCBF, DSC-rCBF and DSC-rCBV were cutoff at 2.24, 1.85 and 1.68, the sensitivity of HGG diagnosis was 83.2, 91.3 and 91.3%, and the specificity was 77.7, 63.9 and 66.7%, respectively.

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Section: Discussionmentioning

confidence: 99%

“…Therefore, 3D ASL retains the primitive physiological or pathological conditions to obtain hemodynamic parameters (19). The results of 3D ASL have high repeatability and good economic value.…”

Section: Discussionmentioning

confidence: 99%

Three-dimensional arterial spin labeling imaging and dynamic susceptibility contrast perfusion-weighted imaging value in diagnosing glioma grade prior to surgery

Wang

et al. 2017

Experimental and Therapeutic Medicine

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“…Proton MR spectroscopy has emerged as an adjunct imaging modality superior in its ability to detect the full extent of injury in the first 24 h. In particular, lactate to N-acetylaspartate ratios have been correlated with long-term prognosis [73,75,76,[78][79][80]. Arterial spin labeling noninvasively assesses cerebral blood flow by inverting arterial hydrogen protons and has recently been used more frequently in the pediatric population [81,82]. Studies have used arterial spin labeling to characterize the timeline and pattern of changes in cerebral blood flow in neonates with HIE [83,84]; arterial spin labeling perfusion values, particularly in the basal ganglia and thalamus, correlate with outcomes, especially when combined with MR spectroscopy information [85].…”

Section: Reliability and Predictive Value Of Us Findingsmentioning

confidence: 99%

Head Ultrasound in Neonatal Hypoxic-Ischemic Injury and Its Mimickers for Clinicians: A Review of the Patterns of Injury and the Evolution of Findings Over Time

et al. 2018

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Hypoxic-ischemic injury (HII) of the neonatal brain and resulting clinical hypoxic-ischemic encephalopathy remains a significant cause of morbidity and mortality in the neonatal population. Ultrasound (US) has emerged as a powerful screening tool for evaluation of a neonate with suspected HII. The pattern of injury on brain imaging has crucial implications in therapies and predicted neurodevelopmental outcomes. US has become increasingly effective at determining the pattern, timing, and extent of injury in HII as well as differentiating these findings from a host of diagnoses that can result in a similarly appearing clinical picture. Repeated US studies over a patient’s course can define the evolution of findings from the acute through chronic phase in addition to identifying any complications of therapy. US also has the added benefits of easy portability, no need for patient sedation, and a relatively low cost when compared to other imaging modalities like magnetic resonance imaging (MRI). It is crucial that clinicians understand the full capabilities of advanced US in identifying an underlying diagnosis, directing appropriate therapy, monitoring disease progress, and finally in predicting outcomes, thus improving the care of neonates with encephalopathy. The following article demonstrates the breadth of uses for US in the full-term neonate with encephalopathy, its limitations, the patterns of injury seen, and their evolution over time. We will also briefly review several clinical mimickers of HII for comparison.

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“…Arterial spin labeling (ASL) is a well‐established noninvasive perfusion MRI technique, used increasingly in clinical applications . Ever since the original ASL work by Detre et al and Williams et al, the equilibrium magnetization of arterial blood water (

M_{0 a}

) has been identified as the central calibration factor for converting perfusion‐weighted signal to quantitative perfusion values.…”

Section: Introductionmentioning

confidence: 99%

Improved calculation of the equilibrium magnetization of arterial blood in arterial spin labeling

Ahlgren¹,

Wirestam²,

Knutsson

et al. 2018

Magnetic Resonance in Med

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Compared with the conventional approach, the proposed method produced more homogenous M0a maps, corresponding to a more accurate calibration. The proposed method also yielded significantly different perfusion values across the whole brain, and performed consistently in all subjects. The new M0a method improves quantitative perfusion estimation with arterial spin labeling, and can therefore be of considerable value in perfusion imaging applications.

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Arterial Spin Labeling Perfusion of the Brain: Emerging Clinical Applications

Cited by 377 publications

References 140 publications

Three-dimensional arterial spin labeling imaging and dynamic susceptibility contrast perfusion-weighted imaging value in diagnosing glioma grade prior to surgery

Three-dimensional arterial spin labeling imaging and dynamic susceptibility contrast perfusion-weighted imaging value in diagnosing glioma grade prior to surgery

Head Ultrasound in Neonatal Hypoxic-Ischemic Injury and Its Mimickers for Clinicians: A Review of the Patterns of Injury and the Evolution of Findings Over Time

Improved calculation of the equilibrium magnetization of arterial blood in arterial spin labeling

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