Arterial Spin-Labeling Parameters Influence Signal Variability and Estimated Regional Relative Cerebral Blood Flow in Normal Aging and Mild Cognitive Impairment: FAIR versus PICORE Techniques

Lövblad, K O; Montandon, Marie‐Louise; Viallon, Magalie; Rodriguez, Cristelle; Toma, Simona; Golay, Xavier; Giannakopoulos, Pantéleimon; Haller, Sven

doi:10.3174/ajnr.a4291

Cited by 7 publications

(3 citation statements)

References 30 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…61). Arterial Spin Labelling MR offers a non invasive method to assess Cerebral Blood Flow and is an emerging biomarker for MCI and AD62. Diminished CBF reduces brain supply of oxygen, energy substrates and nutrients, impairs the clearance of neurotoxic molecules, and this is known to contribute to neuronal dysfunction found in neurodegenerative disorders, which are of early appearance in Medial Temporal Lobe regions.…”

Section: Discussionmentioning

confidence: 99%

Randomized trial on the effects of a combined physical/cognitive training in aged MCI subjects: the Train the Brain study

Maffei¹,

Picaño²,

Andreassi³

et al. 2017

Sci Rep

114

View full text Add to dashboard Cite

Age-related cognitive impairment and dementia are an increasing societal burden. Epidemiological studies indicate that lifestyle factors, e.g. physical, cognitive and social activities, correlate with reduced dementia risk; moreover, positive effects on cognition of physical/cognitive training have been found in cognitively unimpaired elders. Less is known about effectiveness and action mechanisms of physical/cognitive training in elders already suffering from Mild Cognitive Impairment (MCI), a population at high risk for dementia. We assessed in 113 MCI subjects aged 65–89 years, the efficacy of combined physical-cognitive training on cognitive decline, Gray Matter (GM) volume loss and Cerebral Blood Flow (CBF) in hippocampus and parahippocampal areas, and on brain-blood-oxygenation-level-dependent (BOLD) activity elicited by a cognitive task, measured by ADAS-Cog scale, Magnetic Resonance Imaging (MRI), Arterial Spin Labeling (ASL) and fMRI, respectively, before and after 7 months of training vs. usual life. Cognitive status significantly decreased in MCI-no training and significantly increased in MCI-training subjects; training increased parahippocampal CBF, but no effect on GM volume loss was evident; BOLD activity increase, indicative of neural efficiency decline, was found only in MCI-no training subjects. These results show that a non pharmacological, multicomponent intervention improves cognitive status and indicators of brain health in MCI subjects.

show abstract

Section: Discussionmentioning

confidence: 99%

Randomized trial on the effects of a combined physical/cognitive training in aged MCI subjects: the Train the Brain study

Maffei¹,

Picaño²,

Andreassi³

et al. 2017

Sci Rep

114

View full text Add to dashboard Cite

show abstract

“…PASL showed higher CBF in the posterior circulation, cerebellum, and basal ganglia and lower CBF in the frontal lobe whereas BS 3D PCASL had an exactly opposite distribution. Although much of this difference can be attributed to the different labeling and acquisition schemes [Lovblad et al, ], differences in effective PLD and their mismatch with ATT also likely contributed. ATT can be measured experimentally, and would be highly beneficial for optimal accuracy in CBF quantification.…”

Section: Discussionmentioning

confidence: 99%

“…The method converts each correlation coefficient into a z ‐score using Fisher's r ‐to‐ z transformation, computes the asymptotic covariance of the estimates, and subsequently uses the quantities in an asymptotic z ‐test. We also compared the regional distribution of CBF between the three modalities based on the control subjects, as prior studies—e.g., Lovblad et al []—showed that differences in labeling can lead to regional variability and difference in signal intensity.…”

Section: Methodsmentioning

confidence: 99%

Comparison of PASL, PCASL, and background‐suppressed 3D PCASL in mild cognitive impairment

Dolui

Vidorreta

Wang

et al. 2017

Human Brain Mapping

View full text Add to dashboard Cite

We compared three implementations of single-shot arterial spin labeled (ASL) perfusion magnetic resonance imaging (MRI): two-dimensional (2D) pulsed ASL (PASL), 2D pseudo-continuous ASL (PCASL), and background suppressed (BS) 3D PCASL obtained in a cohort of patients with mild cognitive impairment (MCI) and elderly controls. Study subjects also underwent 18F-flurodeoxyglucose positron emission tomography (18F-FDG PET). While BS 3D PCASL showed the lowest (p<0.001) gray matter-white matter cerebral blood flow (CBF) contrast ratio, it provided the highest (p<0.001) temporal signal-to-noise ratio. Mean relative CBF estimated using the PCASL methods in posterior cingulate cortex (PCC), precuneus and hippocampus showed hypoperfusion in the MCI cohort compared to the controls consistent with hypometabolism measured by 18F-FDG PET. BS 3D PCASL demonstrated the highest discrimination between controls and patients with effect size comparable to that seen with 18F-FDG PET. 2D PASL did not demonstrate group differentiation with relative CBF in any ROI, whereas 2D PCASL demonstrated significant differences only in PCC and hippocampus. Mean global CBF values did not differ across methods and were highly correlated, however the correlations were significantly higher (p<0.001) when either the same labeling (PCASL) or the same acquisition strategy (2D) was used as compared to when both the labeling and readout methods differed. In addition, there were differences in regional distribution of CBF between the three modalities, which can be attributed to differences in sequence parameters. These results demonstrate the superiority of ASL with PCASL as well as BS 3D readout as a biomarker for regional brain function changes in MCI.

show abstract

Comparison of 2D simultaneous multi-slice and 3D GRASE readout schemes for pseudo-continuous arterial spin labeling of cerebral perfusion at 3 T

Nanjappa

Troalen

Pfeuffer

et al. 2020

Magn Reson Mater Phy

View full text Add to dashboard Cite

Arterial Spin-Labeling Parameters Influence Signal Variability and Estimated Regional Relative Cerebral Blood Flow in Normal Aging and Mild Cognitive Impairment: FAIR versus PICORE Techniques

Cited by 7 publications

References 30 publications

Randomized trial on the effects of a combined physical/cognitive training in aged MCI subjects: the Train the Brain study

Randomized trial on the effects of a combined physical/cognitive training in aged MCI subjects: the Train the Brain study

Comparison of PASL, PCASL, and background‐suppressed 3D PCASL in mild cognitive impairment

Comparison of 2D simultaneous multi-slice and 3D GRASE readout schemes for pseudo-continuous arterial spin labeling of cerebral perfusion at 3 T

Contact Info

Product

Resources

About