Arterial spin labeling MRI: Clinical applications in the brain

Telischak, N; Detre, John A.; Zaharchuk, Greg

doi:10.1002/jmri.24751

Cited by 171 publications

(136 citation statements)

References 65 publications

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“…Indeed, Jann et al showed that CBF-based FC analysis revealed greater connectivity of the DMN in the prefrontal cortex compared to BOLD, in agreement with findings by Tak et al (Tak et al, 2013). It was also found that the amplitude of low frequency fluctuation (ALFF) computed from CBF time series was significantly different across RBNs and subjects (Fig.…”

Section: Perfusion-based Functional Connectivity Mappingsupporting

confidence: 61%

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Characterizing Resting-State Brain Function Using Arterial Spin Labeling

2015

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Arterial spin labeling (ASL) is an increasingly established magnetic resonance imaging (MRI) technique that is finding broader applications in studying the healthy and diseased brain. This review addresses the use of ASL to assess brain function in the resting state. Following a brief technical description, we discuss the use of ASL in the following main categories: (1) resting-state functional connectivity (FC) measurement: the use of ASL-based cerebral blood flow (CBF) measurements as an alternative to the blood oxygen level-dependent (BOLD) technique to assess resting-state FC; (2) the link between network CBF and FC measurements: the use of network CBF as a surrogate of the metabolic activity within corresponding networks; and (3) the study of resting-state dynamic CBF-BOLD coupling and cerebral metabolism: the use of dynamic CBF information obtained using ASL to assess dynamic CBF-BOLD coupling and oxidative metabolism in the resting state. In addition, we summarize some future challenges and interesting research directions for ASL, including slice-accelerated (multiband) imaging as well as the effects of motion and other physiological confounds on perfusion-based FC measurement. In summary, this work reviews the state-of-the-art of ASL and establishes it as an increasingly viable MRI technique with high translational value in studying resting-state brain function.

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Section: Perfusion-based Functional Connectivity Mappingsupporting

confidence: 61%

“…A comprehensive overview of clinical studies using ASL can be found in a recent review Telischak et al, 2014), and will not be reiterated in this article.…”

Section: Introductionmentioning

confidence: 97%

Characterizing Resting-State Brain Function Using Arterial Spin Labeling

2015

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“…44 Alternatively, arterial spin-labeling perfusion is a completely noninvasive MR imaging technique that does not require the administration of gadolinium contrast but instead uses an electromagnetic spin inversion to tag water molecules, which then serve as a freely diffusible flow tracer. 45 On the basis of our own clinical experience and a few isolated case reports, perfusion imaging in RCVS may show multifocal areas of hypoperfusion that often include cerebral watershed zones corresponding to the involved vascular territories (Fig 3). 46,47 These areas of perfusion abnormality may worsen acutely and, in some instances, progress to watershed infarction as previously discussed.…”

Section: Perfusion Imagingmentioning

confidence: 99%

Reversible Cerebral Vasoconstriction Syndrome, Part 2: Diagnostic Work-Up, Imaging Evaluation, and Differential Diagnosis

Miller

Shivashankar

Mossa‐Basha

et al. 2015

AJNR Am J Neuroradiol

131

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SUMMARY:The diagnostic evaluation of a patient with reversible cerebral vasoconstriction syndrome integrates clinical, laboratory, and radiologic findings. Imaging plays an important role by confirming the presence of cerebral vasoconstriction; monitoring potential complications such as ischemic stroke; and suggesting alternative diagnoses, including CNS vasculitis and aneurysmal subarachnoid hemorrhage. Noninvasive vascular imaging, including transcranial Doppler sonography and MR angiography, has played an increasingly important role in this regard, though conventional angiography remains the criterion standard for the evaluation of cerebral artery vasoconstriction. Newer imaging techniques, including high-resolution vessel wall imaging, may help in the future to better discriminate reversible cerebral vasoconstriction syndrome from primary angiitis of the CNS, an important clinical distinction. ABBREVIATIONS:PACNS ϭ primary angiitis of the CNS; RCVS ϭ reversible cerebral vasoconstriction syndrome; TCD ϭ transcranial Doppler sonography; VWI ϭ

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“…8 pCASL MRI is a new arterial spin labelling technique that has the potential of combining advantages of continuous arterial spin labelling and pulsed arterial spin labelling. pCASL MRI is an intermediate technique between continuous arterial spin labelling and pulsed arterial spin labelling, which utilizes a series of discrete radiofrequency pulses to mimic the continuous arterial spin labelling method for spin labelling.…”

Section: Introductionmentioning

confidence: 99%

Differentiation of squamous cell carcinoma and inverted papilloma using non-invasive MR perfusion imaging

Fujima¹,

Nakamaru²,

Sakashita³

et al. 2015

Dentomaxillofacial Radiology

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Objectives: To investigate the diagnostic value of tumour blood flow (TBF) obtained with pseudocontinuous arterial spin labelling for the differentiation of squamous cell carcinoma (SCC) and inverted papilloma (IP) in the nasal or sinonasal cavity. Methods: We retrospectively analysed the cases of 33 patients with SCC and 8 patients with IP in the nasal or sinonasal cavity. Pseudocontinuous arterial spin labelling scanning was performed for all patients using a 3.0-T MR unit. Quantitative TBF values were measured by two neuroradiologists by respectively delineating the whole-tumour regions of interest, and the mean of them was determined as TBF value in each patient. Additionally, the presence of imaging findings of convoluted cerebriform pattern (CCP) on MR T 2 weighted images was determined in all patients. As a subgroup analysis, patients with IP were divided into aggressive and non-aggressive IPs depending on their progression range. First, an intraclass correlation coefficient (ICC) of TBF values between two neuroradiologists was determined. Next, a statistical comparison of the TBF value by a Mann-Whitney U test between the patients with SCC and IP was performed. Additionally, the comparison by an ANOVA with a post hoc test of Tukey's method among the SCC, non-aggressive IP and aggressive IP groups was also performed. If significance was observed, the diagnostic accuracy to differentiate SCCs from IPs was calculated. Diagnostic accuracy by CCP findings alone and by the combination of CCP findings and TBF were also assessed. Results: The ICC of TBF values between two neuroradiologists was 0.82. The mean TBF values in the patients with SCC, all patients with IP, those with aggressive IP and those with non-aggressive IP were 141.2 ± 33.1, 77.8 ± 31.5, 109.4 ± 16.7 and 58.8 ± 19.9 ml 100 g 21 min 21, respectively. A significant difference was observed between SCC and IP (p , 0.001), SCC and non-aggressive IP (p , 0.01) and non-aggressive IP and aggressive IP (p , 0.01). The diagnostic accuracy values obtained with receiver operating characteristic curve analysis for the differentiation of SCC from IP and for SCC from non-aggressive IP were 0.90 and 0.92, respectively. The diagnostic accuracy was elevated (0.95 from 0.88) by adding the TBF value to CCP findings. Conclusions:The pseudocontinuous arterial spin labelling technique can be a useful noninvasive diagnostic tool to differentiate SCC from IP in nasal or sinonasal cavity.

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Arterial spin labeling MRI: Clinical applications in the brain

Cited by 171 publications

References 65 publications

Characterizing Resting-State Brain Function Using Arterial Spin Labeling

Characterizing Resting-State Brain Function Using Arterial Spin Labeling

Reversible Cerebral Vasoconstriction Syndrome, Part 2: Diagnostic Work-Up, Imaging Evaluation, and Differential Diagnosis

Differentiation of squamous cell carcinoma and inverted papilloma using non-invasive MR perfusion imaging

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