Arterial spin labeling for moyamoya angiopathy: A preoperative and postoperative evaluation method

Abstract

Objectives Studies have shown that arterial spin labeling (ASL) effectively replaces traditional MRI perfusion imaging for detecting cerebral blood flow (CBF) in patients with Moyamoya angiopathy (MMA). However, there are few reports on the relationship between neovascularization and cerebral perfusion in patients with MMA. The aim of this study is to investigate the effects of neovascularization on cerebral perfusion with MMA after bypass surgery. Methods We selected patients with MMA in the Department of Neurosurgery between September 2019 and August 2021 and enrolled them based on the inclusion and exclusion criteria. ASL imaging was used to monitor the baseline CBF level before surgery and determine the changes in cerebral vessels at postoperative 1 week and 6 months, respectively. The Alberta stroke grade, modified Rankin Scale (mRS), and digital subtraction angiography images were used to evaluate the effect of postoperative CBF status and prognosis. Ninety hemispheres from 51 patients were included in this study. There were no significant differences in the baseline data of the enrolled patients. At 1 week and 6 months post-surgery, the CBF state in the operation area was significantly changed compared with that at baseline (P < 0.05). The preoperative Alberta score (t = 2.714, P = 0.013) and preoperative mRS score (t = 6.678, P < 0.001) correlated with postoperative neovascularization. Conclusion ASL is an effective method for detecting CBF and plays an important role in the long-term follow-up of patients with MMA. Combined cerebral revascularization significantly improves CBF in the operation area both in the short and long terms. Patients with lower preoperative Alberta scores and higher mRS scores were more likely to benefit from combined cerebral revascularization surgery. However, regardless of the type of patient, CBF reconstruction can effectively improve prognosis.

Evaluation of the contribution of individual arteries to the cerebral blood supply in patients with Moyamoya angiopathy: comparison of vessel-encoded arterial spin labeling and digital subtraction angiography

“…A commonly used therapy to prevent ischemic strokes is neurosurgical revascularization. This may be a direct bypass, i.e., direct anastomosis between branch of a donor scalp artery, usually the superficial temporal artery (STA) and a distal branch of a cortical artery (STA-MCA, STA-ACA bypass) or an indirect revascularization where donor artery (EDAS: encephalo-arterio-synangiosis), temporalis muscle, (EMS: encephalo-myo-synangiosis) dura (EDS: encephalo-duro-synangiosis), or galea-periost (EGPS: encephalo-galeaperiost-synangiosis) may be used as a synangiosis triggering neovascularization [ 1 , 3 ].…”