Arterial spin labeling CMR perfusion imaging is capable of continuously monitoring myocardial blood flow during stress

Do, Hung P; Javed, Ahsan; Jao, Terrence R; Kim, Hee-won; Yoon, Andrew; Nayak, Krishna S.

doi:10.1186/1532-429x-17-s1-p145

Cited by 2 publications

(1 citation statement)

References 0 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Arterial spin labeling (ASL)-CMR is a non-contrast technique for measuring myocardial perfusion (MP) and may be a viable alternative to assess CED that overcomes many of the limitations of current CMR techniques [15][16][17][18][19] . ASL-CMR requires lower spatial resolution than coronary MRI because signals are measured in the myocardium and not in the coronary tree.…”

Section: Introductionmentioning

confidence: 99%

Feasibility of coronary endothelial function assessment using arterial spin labeled CMR

et al. 2019

Self Cite

View full text Add to dashboard Cite

Coronary endothelial dysfunction (CED) is an independent predictor of cardiovascular disease, but its assessment has been limited to invasive coronary angiography. Myocardial perfusion imaging using arterial spin labeled (ASL) cardiac magnetic resonance (CMR) may be an effective noninvasive alternative for detection of CED.Thirty-four patients were recruited: 10 healthy volunteers, 13 at high-risk for coronary artery disease (CAD), and 11 with established CAD. ASL-CMR was performed continuously in a single mid-short axis slice during rest, stress, and recovery. Stress was induced with sustained isometric handgrip exercise, an endothelial dependent stressor. Myocardial perfusion (MP) during rest, peak stress, and recovery were calculated and compared.

show abstract

Section: Introductionmentioning

confidence: 99%

Feasibility of coronary endothelial function assessment using arterial spin labeled CMR

et al. 2019

Self Cite

View full text Add to dashboard Cite

show abstract

Non-contrast assessment of microvascular integrity using arterial spin labeled cardiovascular magnetic resonance in a porcine model of acute myocardial infarction

Ramanan

et al. 2018

Journal of Cardiovascular Magnetic Resonance

View full text Add to dashboard Cite

BackgroundFollowing acute myocardial infarction (AMI), microvascular integrity and function may be compromised as a result of microvascular obstruction (MVO) and vasodilator dysfunction. It has been observed that both infarcted and remote myocardial territories may exhibit impaired myocardial blood flow (MBF) patterns associated with an abnormal vasodilator response. Arterial spin labeled (ASL) CMR is a novel non-contrast technique that can quantitatively measure MBF. This study investigates the feasibility of ASL-CMR to assess MVO and vasodilator response in swine.MethodsThirty-one swine were included in this study. Resting ASL-CMR was performed on 24 healthy swine (baseline group). A subset of 13 swine from the baseline group underwent stress ASL-CMR to assess vasodilator response. Fifteen swine were subjected to a 90-min left anterior descending (LAD) coronary artery occlusion followed by reperfusion. Resting ASL-CMR was performed post-AMI at 1–2 days (N = 9, of which 6 were from the baseline group), 1–2 weeks (N = 8, of which 4 were from the day 1–2 group), and 4 weeks (N = 4, of which 2 were from the week 1–2 group). Resting first-pass CMR and late gadolinium enhancement (LGE) were performed post-AMI for reference.ResultsAt rest, regional MBF and physiological noise measured from ASL-CMR were 1.08 ± 0.62 and 0.15 ± 0.10 ml/g/min, respectively. Regional MBF increased to 1.47 ± 0.62 ml/g/min with dipyridamole vasodilation (P < 0.001). Significant reduction in MBF was found in the infarcted region 1–2 days, 1–2 weeks, and 4 weeks post-AMI compared to baseline (P < 0.03). This was consistent with perfusion deficit seen on first-pass CMR and with MVO seen on LGE. There were no significant differences between measured MBF in the remote regions pre and post-AMI (P > 0.60).ConclusionsASL-CMR can assess vasodilator response in healthy swine and detect significant reduction in regional MBF at rest following AMI. ASL-CMR is an alternative to gadolinium-based techniques for assessment of MVO and microvascular integrity within infarcted, as well as salvageable and remote myocardium. This has the potential to provide early indications of adverse remodeling processes post-ischemia.

show abstract

Arterial spin labeling CMR perfusion imaging is capable of continuously monitoring myocardial blood flow during stress

Cited by 2 publications

References 0 publications

Feasibility of coronary endothelial function assessment using arterial spin labeled CMR

Feasibility of coronary endothelial function assessment using arterial spin labeled CMR

Non-contrast assessment of microvascular integrity using arterial spin labeled cardiovascular magnetic resonance in a porcine model of acute myocardial infarction

Contact Info

Product

Resources

About