Arterial Spin Labeling Blood Flow MRI: Its Role in the Early Characterization of Alzheimer's Disease

Alsop, David C.; Dai, Weiying; Grossman, Murray; Detre, John A.

doi:10.3233/jad-2010-091699

Cited by 192 publications

(187 citation statements)

References 66 publications

(75 reference statements)

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“…This methodology holds particular promise as an early marker of functional change, which may have important prognostic value in preclinical disease and for tracking outcomes in therapeutic intervention trials. 4 Mounting evidence for the utility of various MRI measures such as structural imaging, white matter hyperintensities, and diffusion tensor imaging has established MRI to be a powerful tool for studying AD, 13 but PET remains the gold standard for functional assessments. An MRI-based functional measurement such as ASL could potentially streamline AD studies as it can be easily incorporated into any MRI protocol.…”

Section: Resultsmentioning

confidence: 99%

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Voxel-level comparison of arterial spin-labeled perfusion MRI and FDG-PET in Alzheimer disease

Chen¹,

Wolk²,

Reddin³

et al. 2011

Neurology

224

176

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Objective:We compared the ability of arterial spin labeling (ASL), an MRI method that measures cerebral blood flow (CBF), to that of FDG-PET in distinguishing patients with Alzheimer disease (AD) from healthy, age-matched controls.Methods: Fifteen patients with AD (mean age 72 Ϯ 6 years, Mini-Mental State Examination score[MMSE] 20 Ϯ 6) and 19 age-matched controls (mean age 68 Ϯ 6 years, MMSE 29 Ϯ 1) underwent structural MRI. Participants were injected with 5 mCi of FDG during pseudocontinuous ASL scan, which was followed by PET scanning. Statistical parametric mapping and regions of interest (ROI) analysis were used to compare the ability of the 2 modalities in distinguishing patients from controls. Similarity between the 2 modalities was further assessed with linear correlation maps of CBF and metabolism to neuropsychological test scores. Results:Good agreement between hypoperfusion and hypometabolism patterns was observed, with overlap primarily in bilateral angular gyri and posterior cingulate. ROI results showed similar scales of functional deficit between patients and controls in both modalities. Both ASL and FDG-PET were able to distinguish neural networks associated with different neuropsychological tests with good overlap between modalities. Conclusions:

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Section: Resultsmentioning

confidence: 99%

“…Though patterns of hypoperfusion in limited ASL studies largely recapitulate hypometabolism patterns reported with FDG-PET (for review, see reference 13 ), no direct comparison between the methodologies for AD exists. Here, we compare the ability of ASL and FDG-PET to distinguish patients with AD from controls.…”

mentioning

confidence: 99%

Voxel-level comparison of arterial spin-labeled perfusion MRI and FDG-PET in Alzheimer disease

Chen¹,

Wolk²,

Reddin³

et al. 2011

Neurology

224

176

View full text Add to dashboard Cite

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“…Three-dimensional continuous arterial spin labeling (CASL) was used for noninvasive mapping of cerebral blood flow. 7,8 Image processing. Images were analyzed using tools developed in interactive data language (Research Systems, Boulder, CO) and MATLAB (MathWorks, Natick, MA).…”

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confidence: 99%

Inflammation-associated declines in cerebral vasoreactivity and cognition in type 2 diabetes

et al. 2015

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Objective: The aim of this prospective study was to investigate the relationships between inflammation, cerebral vasoregulation, and cognitive decline in type 2 diabetes mellitus (T2DM) over a 2-year span.Methods: Sixty-five participants (aged 66 6 9.2 years, 35 with T2DM, 33 women) were enrolled for this 2-year prospective study. Continuous arterial spin labeling at 3-tesla MRI was used to measure global and regional cerebral perfusion and vasoreactivity. Neuropsychological measures were evaluated at the beginning and completion of the study. The associations between serum inflammatory markers, regional cerebral vasoreactivity, and cognitive functions were examined using least squares models.Results: After 2 years of follow-up, participants with T2DM had diminished global and regional cerebral vasoreactivity and a decline in multiple cognitive tasks compared with baseline (p , 0.0001-0.012). In the T2DM group, lower cerebral vasoreactivity was associated with a greater decrease in daily living activities score (r Type 2 diabetes mellitus (T2DM) has been recognized as an independent risk for development of cognitive impairment and dementia.1,2 Endothelial dysfunction and impaired cerebral vasoregulation associated with hyperglycemia and elevated proinflammatory cytokine levels have been linked to functional decline in T2DM.3-5 The aim of this study was to prospectively determine the associations between inflammation, cerebral vasoregulation, and cognitive performance over a 2-year span in older adults with and without T2DM. We hypothesized that (1) inflammation and hyperglycemia are associated with impaired vasoregulation in the brain, and (2) impaired vasoregulation is associated with cognitive decline in T2DM.

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“…The fMRI technique providing the most quantitative measure of CBF is arterial spin labeling (ASL). [8][9][10] Cerebral vascular reactivity can thus be expressed as the percentage or absolute change in CBF per mm Hg change in the end-tidal partial pressure of CO 2 (P ET CO 2 , a surrogate for arterial PCO 2 ). In addition to providing a direct depiction of cerebral vascular function, the ASL and BOLD responses to a hypercapnic manipulation can be input to biophysical models allowing estimation of the cerebral metabolic rate of O 2 , 11,12 a key indicator of cerebral function.…”

Section: Introductionmentioning

confidence: 99%

Comparison of Cerebral Vascular Reactivity Measures Obtained Using Breath-Holding and CO₂ Inhalation

Tancredi

Hoge

2013

J Cereb Blood Flow Metab

119

116

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Stimulation of cerebral vasculature using hypercapnia has been widely used to study cerebral vascular reactivity (CVR), which can be expressed as the quantitative change in cerebral blood flow (CBF) per mm Hg change in end-tidal partial pressure of CO 2 (P ET CO 2 ). We investigate whether different respiratory manipulations, with arterial spin labeling used to measure CBF, lead to consistent measures of CVR. The approaches included: (1) an automated system delivering variable concentrations of inspired CO 2 for prospective targeting of P ET CO 2 , (2) administration of a fixed concentration of CO 2 leading to subject-dependent changes in P ET CO 2 , (3) a breath-hold (BH) paradigm with physiologic modeling of CO 2 accumulation, and (4) a maneuver combining breathhold and hyperventilation. When CVR was expressed as the percent change in CBF per mm Hg change in P ET CO 2 , methods 1 to 3 gave consistent results. The CVR values using method 4 were significantly lower. When CVR was expressed in terms of the absolute change in CBF (mL/100 g per minute per mm Hg), greater discrepancies became apparent: methods 2 and 3 gave lower absolute CVR values compared with method 1, and the value obtained with method 4 was dramatically lower. Our findings indicate that care must be taken to ensure that CVR is measured over the linear range of the CBF-CO 2 dose-response curve, avoiding hypocapnic conditions.

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Arterial Spin Labeling Blood Flow MRI: Its Role in the Early Characterization of Alzheimer's Disease

Cited by 192 publications

References 66 publications

Voxel-level comparison of arterial spin-labeled perfusion MRI and FDG-PET in Alzheimer disease

Voxel-level comparison of arterial spin-labeled perfusion MRI and FDG-PET in Alzheimer disease

Inflammation-associated declines in cerebral vasoreactivity and cognition in type 2 diabetes

Comparison of Cerebral Vascular Reactivity Measures Obtained Using Breath-Holding and CO₂ Inhalation

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Arterial Spin Labeling Blood Flow MRI: Its Role in the Early Characterization of Alzheimer's Disease

Cited by 192 publications

References 66 publications

Voxel-level comparison of arterial spin-labeled perfusion MRI and FDG-PET in Alzheimer disease

Voxel-level comparison of arterial spin-labeled perfusion MRI and FDG-PET in Alzheimer disease

Inflammation-associated declines in cerebral vasoreactivity and cognition in type 2 diabetes

Comparison of Cerebral Vascular Reactivity Measures Obtained Using Breath-Holding and CO2 Inhalation

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Comparison of Cerebral Vascular Reactivity Measures Obtained Using Breath-Holding and CO₂ Inhalation