Arterial Pulse Waveform Characteristics Difference between the Three Trimesters of Healthy Pregnant Women

Abstract

During pregnancy, the pregnant mother undergoes significant physiological changes in order to accommodate the developing fetus. In recent years, arterial pulse wave has been widely used to reflect these physiological changes. The aim of this study was to investigate the changes of radial pulse and photoplethysmography (PPG) pulse waveform characteristic with gestational age in normal pregnant women. 40 pregnant women volunteers were recruited from February 2016 to September 2016 from the Haidian Maternal & Child Health Hospital in Beijing. Both radial pulses and PPG pulses were recorded simultaneously using a PowerLab data collection system at a sampling rate of 1000Hz for offline analysis. Their pulses were measured from each pregnant woman at three trimesters (first trimester between week 11-13; second trimester between week 20-22 and the third trimester between week 37-39). Three waveform characteristics (total pulse area; pulse area1: the area before the notch position; pulse area2: the area after the notch position) were derived. The results showed that the total pulse area and pulse area2 from both radial and PPG pulses decreased significantly between two paired consecutive trimesters (all P<0.01, except the comparisons between the second and third trimesters for PPG pulses). In summary, this study has quantified the pulse waveform characteristic differences in terms of pulse areas between the three trimesters, providing useful scientific evidence to better understand the cardiovascular physiological changes during normal pregnancy.