Arterial pulse pressure amplification described by means of a nonlinear wave model: characterization of human aging

Alfonso, M. R.; Cymberknop, Leandro J.; Armentano, Ricardo L.; Pessana, Franco; Wray, Sandra; Legnani, Walter

doi:10.1088/1742-6596/705/1/012029

Cited by 4 publications

(4 citation statements)

References 8 publications

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“…Pulse pressure propagation was represented as a combination of solitons (a solitary wave packet that maintains its shape while it propagates at a constant velocity) due to the fact that many of the phenomena observed during that kind of propagation is observed along the systemic circulation [ 46 ]. A compartmental model was designed in order to evaluate the pressure pulse amplification variation linked to arterial aging.…”

Section: Applied Nonlinear Dynamicsmentioning

confidence: 99%

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Quantitative Vascular Evaluation: From Laboratory Experiments to Point-of-Care Patient (Experimental Approach)

Armentano

Cymberknop

2018

CHYR

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This paper illustrates the evolution of our knowledge of arterial mechanics from our initial research works up to the present time. Several techniques focusing on this topic in terms of our experience are discussed. An interdisciplinary team composed by different institutions from Argentina, Uruguay, France and Spain was created to conduct research, to train human resources and to fulfill the inevitable social role of gaining access to technological innovation to improve public health.

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Section: Applied Nonlinear Dynamicsmentioning

confidence: 99%

“…Morphological changes were identified in the synthesized blood pressure waveforms as a consequence of aging ( i.e . due to the increment in arterial stiffness) [ 46 ].…”

Section: Applied Nonlinear Dynamicsmentioning

confidence: 99%

Quantitative Vascular Evaluation: From Laboratory Experiments to Point-of-Care Patient (Experimental Approach)

Armentano

Cymberknop

2018

CHYR

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“…In previous works of our group [ 12 , 13 ], a 1D arterial network was constructed in order to simulate the behavior of synthesized pulse pressure waveforms as a combination of solitons throughout the arterial tree. To this end, the pressure in each segment was computed using the KdV equation (KdVe), where vascular dimensions and elastic constants were obtained from the existing literature [ 14 ].…”

Section: Introductionmentioning

confidence: 99%

A Novel Interpretation for Arterial Pulse Pressure Amplification in Health and Disease

Alfonso

Armentano

Cymberknop

et al. 2018

Journal of Healthcare Engineering

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Arterial pressure waves have been described in one dimension using several approaches, such as lumped (Windkessel) or distributed (using Navier-Stokes equations) models. An alternative approach consists of modeling blood pressure waves using a Korteweg-de Vries (KdV) equation and representing pressure waves as combinations of solitons. This model captures many key features of wave propagation in the systemic network and, in particular, pulse pressure amplification (PPA), which is a mechanical biomarker of cardiovascular risk. The main objective of this work is to compare the propagation dynamics described by a KdV equation in a human-like arterial tree using acquired pressure waves. Furthermore, we analyzed the ability of our model to reproduce induced elastic changes in PPA due to different pathological conditions. To this end, numerical simulations were performed using acquired central pressure signals from different subject groups (young, adults, and hypertensive) as input and then comparing the output of the model with measured radial artery pressure waveforms. Pathological conditions were modeled as changes in arterial elasticity (E). Numerical results showed that the model was able to propagate acquired pressure waveforms and to reproduce PPA variations as a consequence of elastic changes. Calculated elasticity for each group was in accordance with the existing literature.

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“… 2014 ; Willemet and Alastruey 2015 ; Alfonso et al. 2016 ), even coupled to the cerebrospinal fluid system (Martin et al. 2012 ).…”

Section: Introductionmentioning

confidence: 99%

Arterial pulse attenuation prediction using the decaying rate of a pressure wave in a viscoelastic material model

Menacho

Rotllant

Molins

et al. 2017

Biomech Model Mechanobiol

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The present study examines the possibility of attenuating blood pulses by means of introducing prosthetic viscoelastic materials able to absorb energy and damp such pulses. Vascular prostheses made of polymeric materials modify the mechanical properties of blood vessels. The effect of these materials on the blood pulse propagation remains to be fully understood. Several materials for medical applications, such as medical polydimethylsiloxane or polytetrafluoroethylene, show viscoelastic behavior, modifying the original vessel stiffness and affecting the propagation of blood pulses. This study focuses on the propagation of pressure waves along a pipe with viscoelastic materials using the Maxwell and the Zener models. An expression of exponential decay has been obtained for the Maxwell material model and also for low viscous coefficient values in the Zener model. For relatively high values of the viscous term in the Zener model, the steepest part of the pulse can be damped quickly, leaving a smooth, slowly decaying wave. These mathematical models are critical to tailor those materials used in cardiovascular implants to the mechanical environment they are confronted with to repair or improve blood vessel function.Electronic supplementary materialThe online version of this article (10.1007/s10237-017-0980-9) contains supplementary material, which is available to authorized users.

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Arterial pulse pressure amplification described by means of a nonlinear wave model: characterization of human aging

Cited by 4 publications

References 8 publications

Quantitative Vascular Evaluation: From Laboratory Experiments to Point-of-Care Patient (Experimental Approach)

Quantitative Vascular Evaluation: From Laboratory Experiments to Point-of-Care Patient (Experimental Approach)

A Novel Interpretation for Arterial Pulse Pressure Amplification in Health and Disease

Arterial pulse attenuation prediction using the decaying rate of a pressure wave in a viscoelastic material model

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