Arterial Occlusion Precipitated by Cisplatinbased Chemotherapy

Joseph, Deepa; Dubashi, Biswajit; Karthikeyan, Badri; Jain, Ankit

doi:10.3747/co.v17i6.728

Cited by 5 publications

(2 citation statements)

References 4 publications

(4 reference statements)

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“…This may have arisen particularly because our patient also had risk factors for arterial insufficiency, including a history of pre-existing peripheral vascular disease and smoking. Occlusive arterial disease can be encountered in the context of cisplastin chemotherapy for testicular cancers, 4 but to our knowledge, this the first reported case in which acute limb ischaemia was the initial clinical presentation that led to the diagnosis of metastatic seminoma.…”

Section: Discussionmentioning

confidence: 86%

Metastatic testicular seminoma presenting as acute lower limb ischaemia

Chui,

Gurrala,

Hosking

et al. 2024

Urology Case Reports

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Section: Discussionmentioning

confidence: 86%

Metastatic testicular seminoma presenting as acute lower limb ischaemia

Chui,

Gurrala,

Hosking

et al. 2024

Urology Case Reports

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“…Digital gangrene most commonly occurs in children as a catheter-related complication [ 4 , 5 ]. The other causes are sepsis, vasculitis, hypercoagulability [6] , paraneoplastic syndrome [ 7 , 8 ], and chemotherapy [ 9 – 11 ]. To date, the only report on digital gangrene in a patient with retinoblastoma is the one by Das et al [7] .…”

Section: Introductionmentioning

confidence: 99%

Digital Gangrene and Antiphospholipid Syndrome in a Retinoblastoma Patient with Chromosome 13q Deletion: A Case Report

Wangtiraumnuay¹,

Surukrattanaskul²,

Wangkittikul³

2023

Case Rep Oncol

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A 19-month-old girl with Cornelia de Lange-like dysmorphic features presented with left eye leukocoria. She was diagnosed with 13q deletion retinoblastoma grade 4 with high-risk features and bone marrow involvement. She underwent enucleation, and the first course of intravenous chemotherapy was initiated. On day 10 after the first chemotherapy dose, she developed digital gangrene of her left hand. She was diagnosed with acute artery occlusion and limb ischemia. Thrombophilia work-up revealed antiphospholipid antibodies, and paraneoplastic syndrome is another possible cause of digital gangrene. The patient’s left thumb and index finger were amputated. After 1 month of hospitalization, she was discharged. Before the second course of chemotherapy, the patient died of systemic metastatic retinoblastoma with respiratory failure due to pneumonia. Our postulation of the mechanism for digital gangrene was the combination of chemotherapy, paraneoplastic syndrome, and antiphospholipid syndrome. Digital gangrene could be a poor prognostic indicator in patients with retinoblastoma.

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