Arterial hypertension in school-aged children in western Romania

Chirita-Emandi, Adela; Puiu, Maria; Gafencu, Mihai; Pienar, Corina

doi:10.1017/s104795111200087x

Cited by 5 publications

(4 citation statements)

References 28 publications

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“…This association was also demonstrated in prevalent studies all over the world [2,9,10]. Similar observations were also reported among adolescent population in the Czech Republic, Romania, and Portugal [20][21][22]. A study that evaluated targeted screening of hypertension in 5207 Swiss children (age 10-14 y) found a 2.2% overall prevalence of hypertension in this population, with 14% overweight/obese [23].…”

Section: © Copyright By Pteidd 2017supporting

confidence: 78%

Epidemiological aspects of obesity and systemic hypertension amongschool children of Western Ukraine

Pavlyshyn¹,

Furdela²,

Kovalchuk³

et al. 2017

Pediatr Endocrino Diabetes Metab

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The boys are three times more often obese than girls and 1.4 times more often overweight. The blood pressure is directly correlated with increased BMI, waist and hip circumference in the examined children. The abdominal obesity is a predictor of hypertension in adolescents. The result of the present study has demonstrated the real epidemiology of obesity and systemic hypertension in children and adolescents, and should motivate family doctors and paediatricians to prevent this pathology in Ukraine.

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Section: © Copyright By Pteidd 2017supporting

confidence: 78%

Epidemiological aspects of obesity and systemic hypertension amongschool children of Western Ukraine

Pavlyshyn¹,

Furdela²,

Kovalchuk³

et al. 2017

Pediatr Endocrino Diabetes Metab

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show abstract

“…The data that has been pooled together here mostly reflects the urban area (75% of children). A single study [63] provided data regarding the difference between the prevalence of excess weight in the rural versus urban areas, finding a slight excess in the rural environment (27.9% as opposed to 24.9%). This trend was also noted in the National Institute of Health report [6].…”

Section: Discussionmentioning

confidence: 99%

Untitled

2020

Ro J Pediatr.

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Introduction. Excess weight has been recognized as a global health issue for many years. It is an established risk factor for several chronic conditions, notably cardiovascular disease and diabetes, and is increasingly present in the pediatric population. The purpose of this paper is to review the existent local data regarding pediatric excess weight (including obesity) and its impact. Method. A review of existent literature from the year 2000 and onwards was performed. Only material referring to a Romanian cohort (or subgroup) was included. Results. Of the initial 455 identified records, 62 full text papers in English and Romanian were considered relevant to the topic and analyzed. A mean prevalence of excess weight of 31.6% (WHO), 18.35% (CDC) and 21.37% (IOTF) with obesity rates of 11.4% (WHO), 7.2% (CDC) and 7.69% (IOTF) was calculated. Several factors that could promote excess weight have been identified in Romanian cohorts and are presented. Possible complications are in line with previous published data and mainly involve the cardiovascular system and metabolic effects. Psychological obesity-associated issues have also been reported. Discussion. To our knowledge, there has not been a local study to assess the prevalence of pediatric excess weight at a country level. The available prevalence data is in line with both previous reports of Romanian data and international figures. There does not appear to be an increase in rates over time in the last few years. Systematic country-level attempts to tackle the excess weight problem are few, however smaller range communitybased intervention programs have been reported, with modest results. Conclusions. A worrying proportion of children are overweight or obese in Romania and this may lead to a variety of physical and psychological issues for the child. Conditions such as arterial hypertension and dyslipidemia, typically encountered in adults, are being noted with increased frequency in the pediatric population and their full impact on quality of life and life expectancy is difficult to grasp. Sustained, community-based interventions could possibly achieve a slow reduction in the rates of pediatric excess weight.

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“…For occipitofrontal circumference (OFC), if percentiles were not given directly from clinicians, percentile values were derived from the age- and sex-appropriate Word Health Organization tables (https://www.who.int/tools/child-growth-standards/standards/head-circumference-for-age). The OFC percentile for one person whose measurements were taken when they were above 5 years old was derived from tables published in Adela Chirita-Emandi et al 6 . For calculating central tendency statistics, OFC percentiles given as a range (e.g.…”

Section: Methodsmentioning

confidence: 99%

Loss of symmetric cell division of apical neural progenitors drivesDENND5A-related developmental and epileptic encephalopathy

Banks

Kharfallah

Fonov

et al. 2022

Preprint

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Epileptic encephalopathies comprise a clinically and genetically heterogenous group of disorders characterized by global developmental delay and ongoing seizure activity. It is generally considered that seizure activity is the primary pathology and leads to altered cognitive function. However, epileptic encephalopathy can also result from primary defects in neurodevelopment that lead to seizures. Here we examine the symptomology of individuals with epileptic encephalopathy resulting from biallelic pathogenic variants in DENND5A, encoding a protein involved in intracellular membrane trafficking. We established a cohort of 15 individuals from 14 families with 21 unique variants in DENND5A and analyzed phenotypic surveys answered by their treating clinicians. We obtained cells derived from several cohort members and examined DENND5A expression and stability, and we examined the role of DENND5A in symmetric cell division capability. Finally, we generated a mouse line expressing a homozygous mutation found in the cohort and analyzed brain morphology in vivo using a 7 Tesla magnetic resonance imaging system. Our cohort study reveals that global developmental delay, gross abnormalities in brain development including ventriculomegaly and corpus callosum dysgenesis, seizures, microcephaly and hypotonia are found in the majority of the cohort. Patient-derived neural precursor cells from induced pluripotent stem cells, as well as patient-derived lymphoblasts, display loss of DENND5A protein and exhibit problems with symmetric cell division, an essential process in early neural development. The introduction of a homozygous human point mutation into the conserved sequence in mouse leads to an animal with reduced brain volume and widespread regional brain dysgenesis and ventriculomegaly, phenotypes shared with the human cohort. Taken together, our multi-dimensional study establishes DENND5A as a critical gene during neurodevelopment and that biallelic loss of function variants, including missense and truncating variants as well as intronic splice site variants, result in a developmental epileptic encephalopathy.

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Arterial hypertension in school-aged children in western Romania

Cited by 5 publications

References 28 publications

Epidemiological aspects of obesity and systemic hypertension amongschool children of Western Ukraine

Epidemiological aspects of obesity and systemic hypertension amongschool children of Western Ukraine

Untitled

Loss of symmetric cell division of apical neural progenitors drivesDENND5A-related developmental and epileptic encephalopathy

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