Arterial crush injury causes decrease in tissue perfusion at the level of the microcirculation in skeletal muscle flap

Krapohl, Björn Dirk; Mailänder, P.; Siemionow, Maria; Giunta, Riccardo E.

doi:10.1002/(sici)1098-2752(1999)19:8<364::aid-micr3>3.0.co;2-j

Cited by 3 publications

(2 citation statements)

References 11 publications

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“…Krapohl et al [45] showed that a crush injury to the arteries supplying the cremasteric muscle in rats resulted in a significant decrease in skeletal muscle perfusion even though the blood supply though the crushed vessel is maintained and that this may be due to thrombogenic results.…”

Section: Essentials Of Hand Surgerymentioning

confidence: 99%

Crush Injuries of the Hand Part I: History, Mechanism and Pathomechanics

Ahmad¹,

Heng²

2018

Essentials of Hand Surgery

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This chapter, the first of two; deals with the basics of crush injuries of the hand as opposed to crush syndrome. The definition is explained and the differences are outlined. A journey through the historical review of the causative mechanisms gives the reader an insight into the machines inflicting a spectrum of injuries and their sequelae. We see how the tools either remain the same or change with time, exacting similar types of injuries but in a different manner and timescale due to mechanisation. Thus it is vital to grasp the mechanics to get a basic understanding of the pathomechanics, enabling one to address the injury by reversing the inflictive force while maintaining respect for the machine. These are humbling injuries that require experience, expertise and enterprise by a dedicated and cohesive team always open to learning.

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Section: Essentials Of Hand Surgerymentioning

confidence: 99%

Crush Injuries of the Hand Part I: History, Mechanism and Pathomechanics

Ahmad¹,

Heng²

2018

Essentials of Hand Surgery

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“…199720 , Krapohl und Mitarb. 1998 17 und 199914,15,16 ) sowie bei Ischämie-Reperfusionsreaktionen(Smith und Mitarb. 1989 24 , Siemionow und Mitarb.…”

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Modell zur allogenen Extremitätentransplantation der Ratte mit Möglichkeit des mikrozirkulatorischen Monitoring*

Krapohl¹,

Siemionow²

2000

Handchir Mikrochir plast Chir

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A rat model for monitoring allograft rejection of transplanted rat hindlimbs at the microcirculatory level is described. The well-established rat cremaster flap model is combined with a rat hindlimb transplantation procedure at a level proximal to the neurovascular pedicle of the cremaster muscle. The cremaster serves as a microcirculatory monitor for in vivo evaluation of graft rejection by measuring skeletal muscle perfusion. Donor animals are male Lewis Brown Norway rats and recipients are Lewis rats. The right cremaster muscle of the donor animal is dissected as a tubular island flap and preserved in a subcutaneous tunnel in the hindlimb. Afterwards, the right hindlimb including the cremaster is amputated at the mid level of the common iliac vessels and transplanted to the recipient at the level of the external iliac vessels. Over a time period of five days, the cremaster muscle of the composite transplants showed appropriate tissue quality for intravital microscopical observations. This transplantation model allows evaluation of allograft rejection in vivo at the microcirculatory level.

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Impact of Severity of Local Soft-Tissue Trauma on Long-Term Manifestation of Microcirculatory and Microlymphatic Dysfunctions

Amon

Laschke²,

Harder³

et al. 2006

The Journal of Trauma: Injury, Infection, and Critical Care

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Only severe trauma of > 450 J/m2 provokes irreversible microcirculatory dysfunction in soft tissue, however, without affecting the integrity of lymphatic microvessels. Of interest, trauma-induced microcirculatory alterations are neither dominated solely by microcirculatory dysfunction nor by leukocytic inflammation. Instead, both pathologies develop in parallel, generating a vicious circle, which may be responsible for the compromised healing of severely traumatized soft tissue frequently observed in clinical practice.

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Arterial crush injury causes decrease in tissue perfusion at the level of the microcirculation in skeletal muscle flap

Cited by 3 publications

References 11 publications

Crush Injuries of the Hand Part I: History, Mechanism and Pathomechanics

Crush Injuries of the Hand Part I: History, Mechanism and Pathomechanics

Modell zur allogenen Extremitätentransplantation der Ratte mit Möglichkeit des mikrozirkulatorischen Monitoring*

Impact of Severity of Local Soft-Tissue Trauma on Long-Term Manifestation of Microcirculatory and Microlymphatic Dysfunctions

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