Arterial blood pressure in adult Nigerians with sickle cell anemia

Oguanobi, Nelson I; Onwubere, Bjc; Ibegbulam, Obike; Ike, SO; Anisiuba, BC; Ejim, EC; Agwu, Obineche

doi:10.1016/j.jjcc.2010.07.001

Cited by 28 publications

(39 citation statements)

References 17 publications

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“…The correlation between increasing haemoglobin and hypertension has also been reported by Pegelow et al (1997), and is partly due to the increased viscosity resulting from the increased numbers of erythrocytes (Johnson, 2005). Likewise, and consistent to our findings, in Nigeria, Oguanobi et al (2010) found an association between hypertension and history of blood transfusion, which may indicate a more severe phenotype. Furthermore, in this cohort where patients depend on top-up blood transfusion instead of exchange transfusion, the chances of both volume expansion and increased haemoglobin levels are high and possibly predispose these patients to hypertension.…”

Section: Discussionsupporting

confidence: 92%

Rates and risk factors of hypertension in adolescents and adults with sickle cell anaemia in Tanzania: 10 years’ experience

et al. 2016

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Summary Data on the magnitude and risk factors for hypertension in sickle cell anaemia (SCA) are limited. A retrospective analysis of individuals with SCA aged ≥15 years enrolled from 2004–2014 at Muhimbili National Hospital, Tanzania was conducted to determine the prevalence, incidence and risk factors for hypertension. A total of 1013 individuals with SCA were analysed, of whom 571(56%) were females. The median age [interquartile range] was 17 [15–22] years. Four hundred and forty-one (44%) of the patients had relative hypertension [systolic blood pressure (SBP) 120–139 mmHg or diastolic blood pressure (DBP) 70–89 mmHg], and 79 (8%) had hypertension (SBP ≥ 140 mmHg or DBP ≥ 90 mmHg). The incidence of hypertension was 64/1000 person years of observation and the 5-year survival rate was 0·71 [95% confidence interval (CI): 0·67–0·75]. In multivariate analysis, age>18 years, Hazard ratio (HR) 1·50 (95% CI: 1·03–2·18); pulse pressure, HR 0·64 (95% CI: 0·42 to 0·98); pulse rate, 1·02 (95% CI: 1·01–1·03); body mass index (BMI), HR 1·08 (95% CI: 1·03–1·13); blood transfusion, HR 2·50 (95% CI: 1·01–6·21) and haemoglobin, HR 1·12 (95% CI: 1·05–1·33) were independently associated with hypertension. In conclusion, despite the younger age, hypertension in this population was higher than that reported in others studies. Age, BMI, pulse pressure and haemoglobin were independently associated with hypertension in SCA.

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Section: Discussionsupporting

confidence: 92%

Rates and risk factors of hypertension in adolescents and adults with sickle cell anaemia in Tanzania: 10 years’ experience

et al. 2016

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“…This study had revealed that SCD patients have lower body mass index as compared to controls. This finding is in agreement with many previous studies (12,13) , this finding could be a consequence of the increased resting energy expenditure caused by the increased erythropoietic and cardiac activities (14) , or it could reflect the greater increase in height than weight usually seen in adolescents with SCD (11)(12)(13)(14)(15) . Decline in endothelial function was observed with increasing duration of symptoms and vaso-occlusive crisis/year in SCD cases.…”

Section: Discussionsupporting

confidence: 93%

Brachial Artery Diameter as a Predictor of Endothelial Dysfunction in Sickle Cell Disease

Al-Janabi¹,

Al-Saadi²,

Hamdani³

et al. 2016

IJMS

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“…Similarly, increased BMI in patients with sickle cell anemia has been shown to be associated with elevated BP and hypertension (8,11-13). In turn, elevated BP has been associated with complications in sickle cell anemia including stroke, kidney disease and early mortality (8-10,21).…”

Section: Discussionmentioning

confidence: 99%

“…Elevated blood pressure (BP) is another modifier of clinical severity in sickle cell anemia, being associated with stroke, renal dysfunction, pulmonary hypertension and early mortality (8-10). Increased body mass index (BMI), which may be a consequence of differences in life-style factors such as dietary habit or activity level as well as other genetic modifiers, is associated with higher BP in patients with sickle cell anemia (8,11-13). …”

Section: Introductionmentioning

confidence: 99%

Comparison of Patients from Nigeria and the USA Highlights Modifiable Risk Factors for Sickle Cell Anemia Complications

Akingbola

Tayo

et al. 2014

Hemoglobin

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To identify factors that affect manifestations of sickle cell anemia we compared patients 11-30 years of age from University of Ibadan, Nigeria (n = 214) and University of Illinois at Chicago, USA (n = 209). Paralleling findings in the general populations of the two countries, the Chicago patients were more often overweight or obese as defined by the Centers for Disease Control (Atlanta, GA, USA) guidelines, and more often had elevated blood pressure (BP) as defined by the National Heart, Lung, and Blood Institute (Bethesda, MD, USA) guidelines. The Ibadan sickle cell anemia patients less frequently received the pneumococcal vaccine or hydroxyurea (HU) therapy. Consistent with lower rates of elevated BP and increased body mass index (BMI), stroke history was less frequent in the Ibadan patients ≥18 years old. Furthermore, in combined analyses, systolic and diastolic BP directly correlated with BMI, and elevated weight status independently associated with history of stroke [odds ratio (OR) 2.7, p = 0.019]. Our findings are consistent with the possibility that higher values for BMI and BP in Chicago sickle cell anemia patients may contribute to an increased risk of stroke and highlights the need for measures to reduce these risk factors. On the other hand, lower pneumococcal vaccination and HU therapy rates in Ibadan patients highlights the need for more improved vaccination coverage and for studies to define the role of HU therapy in Africa.

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Arterial blood pressure in adult Nigerians with sickle cell anemia

Abstract: Relatively lower arterial blood pressure is a significant finding in patients with sickle cell anemia. Hematocrit, frequency of crisis, body mass index, and body surface area are significant determinants of blood pressure indices in sickle cell anemia.

Cited by 28 publications

References 17 publications

Rates and risk factors of hypertension in adolescents and adults with sickle cell anaemia in Tanzania: 10 years’ experience

Rates and risk factors of hypertension in adolescents and adults with sickle cell anaemia in Tanzania: 10 years’ experience

Brachial Artery Diameter as a Predictor of Endothelial Dysfunction in Sickle Cell Disease

Comparison of Patients from Nigeria and the USA Highlights Modifiable Risk Factors for Sickle Cell Anemia Complications

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