Arterial Blood Pressure Estimation From Local Pulse Wave Velocity Using Dual-Element Photoplethysmograph Probe

Nabeel, P M; Karthik, Srinivasa; Joseph, Jayaraj; Sivaprakasam, Mohanasankar

doi:10.1109/tim.2018.2800539

Cited by 55 publications

(19 citation statements)

References 27 publications

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“…The carotid local PWV values (group average = 3.31 ± 0.49 m/s) were less than the typical range of regional PWV assessed from larger arterial sections and muscular arteries [ 38 ]. Reduced values of local PWV was consistently observed in our previous studies [ 31 , 39 , 40 ]. This is also reported by independent researchers working on PWV measurement from elastic arteries [ 38 , 41 ].…”

Section: Resultssupporting

confidence: 88%

Arterial compliance probe for cuffless evaluation of carotid pulse pressure

et al. 2018

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ObjectiveAssessment of local arterial properties has become increasingly important in cardiovascular research as well as in clinical domains. Vascular wall stiffness indices are related to local pulse pressure (ΔP) level, mechanical and geometrical characteristics of the arterial vessel. Non-invasive evaluation of local ΔP from the central arteries (aorta and carotid) is not straightforward in a non-specialist clinical setting. In this work, we present a method and system for real-time and beat-by-beat evaluation of local ΔP from superficial arteries—a non-invasive, cuffless and calibration-free technique.MethodsThe proposed technique uses a bi-modal arterial compliance probe which consisted of two identical magnetic plethysmograph (MPG) sensors located at 23 mm distance apart and a single-element ultrasound transducer. Simultaneously measured local pulse wave velocity (PWV) and arterial dimensions were used in a mathematical model for calibration-free evaluation of local ΔP. The proposed approach was initially verified using an arterial flow phantom, with invasive pressure catheter as the reference device. The developed porotype device was validated on 22 normotensive human subjects (age = 24.5 ± 4 years). Two independent measurements of local ΔP from the carotid artery were made during physically relaxed and post-exercise condition.ResultsPhantom-based verification study yielded a correlation coefficient (r) of 0.93 (p < 0.001) for estimated ΔP versus reference brachial ΔP, with a non-significant bias and standard deviation of error equal to 1.11 mmHg and ±1.97 mmHg respectively. The ability of the developed system to acquire high-fidelity waveforms (dual MPG signals and ultrasound echoes from proximal and distal arterial walls) from the carotid artery was demonstrated by the in-vivo validation study. The group average beat-to-beat variation in measured carotid local PWV, arterial diameter parameters—distension and end-diastolic diameter, and local ΔP were 4.2%, 2.6%, 3.3%, and 10.2% respectively in physically relaxed condition. Consistent with the physiological phenomenon, local ΔP measured from the carotid artery of young populations was, on an average, 22 mmHg lower than the reference ΔP obtained from the brachial artery. Like the reference brachial blood pressure (BP) monitor, the developed prototype device reliably captured variations in carotid local ΔP induced by an external intervention.ConclusionThis technique could provide a direct measurement of local PWV, arterial dimensions, and a calibration-free estimate of beat-by-beat local ΔP. It can be potentially extended for calibration-free cuffless BP measurement and non-invasive characterization of central arteries with locally estimated biomechanical properties.

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Section: Resultssupporting

confidence: 88%

Arterial compliance probe for cuffless evaluation of carotid pulse pressure

et al. 2018

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“…In the study proposed in this paper, the results suggest that the acquisition of local PTT and PWV were very consistent when comparing them to the experiment presented by Nabeel [14], showing that it is possible to use two PPG sensors for obtaining these physiological variables.…”

Section: Resultssupporting

confidence: 70%

“…Therefore, an arithmetic average of the time intervals between the systolic pulse wave peaks is calculated [13]. Considering that the sensors are placed in the same arterial branch, whose distance h is known, according to Nabeel [14], the local PWV can be calculated by section larger than 2 cm.…”

Section: Resultsmentioning

confidence: 99%

A Photoplethysmographic Monitor for Local Pulse Wave Velocity Measurement

Matheus¹,

Antonio²,

Pedro³

et al. 2020

IJCA

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Currently, the available technologies that are capable of monitoring pulse wave velocity (PWV) in a patient are uncomfortable and obstructive. Recently, it has been hypothesized the use of photoplethysmographic (PPG) for this purpose and, therefore, the need to capture and understand the hemodynamic variables used in the PPG signal acquirement process, such as the local pulse transit time (PTT) and local PWV. This work aims to verify the feasibility of the PPG technique in the construction of local PTT and PWV monitor, using PPG sensors and low-cost integrated circuits. In this paper, the low-cost term is used as a synonym for retail sensors, available commercially and commonly used in academic projects for the Arduino platform. It is important for the development of wearable technologies that can be used in a future project to monitor PTT and PWV using a minimally obstructive approach.

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“…To overcome these limitations of cuff-based BP, many cuffless BP technologies have been proposed, including pulse transit time (PTT) or pulse arrival time (PAT), vascular transit time (VTT), tonometry, and pulse wave velocity (PWV) using magnetic sensors as shown in Table 1 [4]- [7].…”

Section: Introductionmentioning

confidence: 99%

Cuffless Blood Pressure Estimation Using Single Channel Photoplethysmography: A Two-Step Method

et al. 2020

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Traditional cuff-based blood pressure (BP) monitoring procedure causes inconvenience and discomfort to the users. To overcome these limitations, cuffless BP estimation based on pulse transit time (PTT) and single-channel photoplethysmography (PPG) has been proposed. However, existing studies based on PTT and PPG for BP estimation did not achieve AAMI/ISO standard criteria for BP measurement (mean difference within ±5mmHg and SD of difference within ±8mmHg) under each BP category (Hypotensive, Normotensive and Hypertensive). This study aims to validate an innovative two-step method for PPGbased cuffless BP estimation. A combined database was derived from two online databases (Queensland and MIMIC II) to cover a wide range of corresponding BPs. In total, there were 18010 raw PPG signal segments (5 seconds for each) with corresponding BPs, separated into two halves for training and testing of algorithms (independent datasets). Each PPG signal segment was pre-processed to extract 16 signal features. Later, three significant features have been selected using multicollinearity test. The traditional generic (trained with uncategorized BP) algorithm and two-step algorithm (specifically optimized for each BP category) were developed using machine learning. Generally, the two-step algorithm achieved the AAMI/ISO standard in estimating systolic BP (mean ±SD: 0.07±7.1 mmHg, p<0.001) and diastolic BP (−0.08±6.0 mmHg, p<0.001). Categorically, the two-step method also achieved standard accuracy in all BP categories except Hypotensive systolic BP whereas generic algorithm did not conform to standard accuracy in any BP category except Hypotensive diastolic BP and Normotensive categories. Compared to the traditional generic algorithm, the two-step algorithm specifically designed for three different BP category patients and achieved standard accuracy for cuffless BP estimation. INDEX TERMS Cuffless BP, pulse transit time, Photoplethysmography & categorical BP estimation.

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Arterial Blood Pressure Estimation From Local Pulse Wave Velocity Using Dual-Element Photoplethysmograph Probe

Cited by 55 publications

References 27 publications

Arterial compliance probe for cuffless evaluation of carotid pulse pressure

Arterial compliance probe for cuffless evaluation of carotid pulse pressure

A Photoplethysmographic Monitor for Local Pulse Wave Velocity Measurement

Cuffless Blood Pressure Estimation Using Single Channel Photoplethysmography: A Two-Step Method

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