Arterial blood gas parameters in pet rabbits anaesthetized using a combination of fentanyl‐fluanisone‐midazolam‐isoflurane

Benato, Livia; Chesnel, Maud-Aline; Eatwell, Kevin; Meredith, Anna

doi:10.1111/jsap.12081

Cited by 13 publications

(12 citation statements)

References 16 publications

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“…Rabbits premedicated with alpha-2 agonist xylazine and general anaesthesia maintained with isoflurane, showed similar results to the current study, that is slight acidemia and increased pCO 2 (BENATO et al, 2013). A reason for hypercapnia may be The value of pCO 2 increased in spontaneously breathing dogs anesthetized with isoflurane and the increase depends on the dose of isoflurane.…”

Section: Discussionsupporting

confidence: 76%

Acid-base balance during volatile and total intravenous anaesthesia in dogs

Capak

Filipović-Genter

Nesek-Adam³

et al. 2017

Vet.arhiv

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The aim of this study was to compare the effects of two different anesthetic techniques on the acid base balance in bitches. Research was carried out on 20 bitches randomly divided into two groups. In group A general anaesthesia was induced by intravenous application of ketamine and diazepam, and maintained with an additional intravenous bolus of ketamine. In group B a combination of propofol and ketamine was used for induction of anaestesia. General anaesthesia was maintained with N 2 O and O 2 in a range of 1:1 in combination with 2% isoflurane. Animals in both groups were kept on spontaneous ventilation. Arterial blood for blood gas analysis was taken at two time points (3 and 45 min. after induction of anaesthesia, respectively). Group A had a significantly (P<0.05) higher pH value than Group B at 45 min. The pCO 2 was significantly (P<0.05) lower in group A than in group B at 3 and 45 min, respectively. There was also a significant difference in values of pO 2 between the groups at 3 and 45 min. The pO 2 was lower in group A than in group B. Group B had a significantly (P<0.05) higher HCO 3 -value than Group A at 45 min. Volatile anaesthesia minimally disturbs acid-base balance, and oxygen access capability is better.

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Section: Discussionsupporting

confidence: 76%

Acid-base balance during volatile and total intravenous anaesthesia in dogs

Capak

Filipović-Genter

Nesek-Adam³

et al. 2017

Vet.arhiv

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“…Statistically significant increases over time in base excess, HCO 3 and TCO 2 were noted for both groups and were increased in comparison with non‐anaesthetised rabbits 37 38. The rabbits in this study appeared to have mild respiratory acidosis as evidenced by significant increases in pCO 2 , which is comparable with other anaesthetised rabbits 39. Because renal compensatory mechanisms are typically not immediate, the increase in HCO 3 − is likely due to the increased CO 2 shifting the reaction CO 2 + H 2 O ⇌ H 2 CO 3 ⇌ HCO 3 + H to the right.…”

Section: Discussionsupporting

confidence: 63%

“…Similar trends were observed in another study comparing blood gas values in sedated rabbits 37. While this metabolic component is difficult to explain, rabbits have been reported to have a wide range of values observed for base excess which is thought to be largely influenced by their diet 39. The rabbits in this study were fed a commercial ration with a high‐fibre content (25–29 per cent) and were not fasted before sample collection.…”

Section: Discussionmentioning

confidence: 99%

Comparison of endoscopic endotracheal intubation and the v‐gel supraglottic airway device for spontaneously ventilating New Zealand white rabbits undergoing ovariohysterectomy

et al. 2020

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BackgroundDue to the technical difficulties with endotracheal intubation of rabbits, a prospective, randomised, controlled study was performed to compare a rabbit-specific supraglottic airway device (SGAD), the v-gel, with endoscopic endotracheal intubation (EEI) in spontaneously breathing rabbits undergoing ovariohysterectomy.MethodsFourteen adult female New Zealand white rabbits were randomly allocated to one of two groups based on the method of airway establishment: EEI or v-gel SGAD. Anaesthesia was induced with ketamine and xylazine and maintained using isoflurane in 100 per cent oxygen. Comparisons were made between groups based on placement time of endotracheal tube/SGAD, number of attempts and adjustments, the necessity to increase isoflurane concentrations to maintain a surgical plane of anaesthesia, arterial blood gas values, gross laryngeal evaluation, and laryngotracheal histopathology.ResultsBoth techniques resulted in elevated arterial pCO2 levels, but the v-gel was associated with more elevated pCO2 in comparison with EEI (P=0.045). Airway trauma was histologically present but clinically negligible in both groups, with no statistically significant differences observed between techniques (P>0.05). Placement time of the v-gel was significantly faster (P=0.003) and required less technical skill than EEI, but was more easily displaced when changing the animal’s position (P=0.004).ConclusionThe v-gel is a practical alternative to EEI for securing the airway of healthy spontaneously ventilating rabbits, provided a capnograph is utilised to ensure continuous placement. Both airway techniques appear safe and effective with few complications, as long as intermittent positive pressure ventilation can be employed to correct hypercapnia.

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“…In addition rabbits have central and superficial ear artery and this artery is visible and easy to collect blood. In rabbit anaesthesia, PaO 2 , PaCO 2 and pH values could be easily determined compared to other laboratory animals 20 .…”

Section: Discussionmentioning

confidence: 99%

The investigation of airway management capacity of v-gel and cobra-PLA in anaesthetised rabbits

et al. 2015

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PURPOSE:To evaluate the applicability and airway management capacity of v-gel ® and Cobra PLA in rabbit anaesthesia during assisted (AV) or controlled ventilation (CV). METHODS:This study was carried out in 44 adult New Zealand white rabbit. Baseline arterial pH, PaCO 2 and PaO 2 values were recorded. Anaesthesia was induced with 5 mg/kg xylasine and 35 mg/kg ketamine HCI combination. AV rabbits were assigned as;control (CG-AV; n=5), LMA (LMA-AV; n=5), cobra PLA (PLA-AV; n=5) and v-gel (v-gelAV; n=5). Rabbits have CV were also assigned as; ET (ET-CV; n=6), LMA (LMA-CV; n=6), cobraPLA (PLA-CV; n=6) and v-gel (v-gelCV; n=6). All measurements were repeated 1st, 5th, 15th and 30th mins during anaesthesia. RESULTS:The less insertion time, number of attempt and complications are recorded in v-gel applied rabbits compared to other apparatus. For arterial pH values significant differences are recorded in especially at 15th and 30th min between groups of CV (p<0.005 or p<0.001). All groups had similar results with each other during anaesthesia for PaCO 2 except for LMA-CV group. CONCLUSION:The v-gel may be used as airway device in rabbit anaesthesia undergoing AV or CV and also can be a suitable alternative to endotracheal tubes and laryngeal mask airway.

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Arterial blood gas parameters in pet rabbits anaesthetized using a combination of fentanyl‐fluanisone‐midazolam‐isoflurane

Abstract: Arterial blood gas analysis is a safe and easy to perform diagnostic technique that can contribute to improved safety of rabbit anaesthesia, by providing information on the respiratory and metabolic status of the patient.

Cited by 13 publications

References 16 publications

Acid-base balance during volatile and total intravenous anaesthesia in dogs

Acid-base balance during volatile and total intravenous anaesthesia in dogs

Comparison of endoscopic endotracheal intubation and the v‐gel supraglottic airway device for spontaneously ventilating New Zealand white rabbits undergoing ovariohysterectomy

The investigation of airway management capacity of v-gel and cobra-PLA in anaesthetised rabbits

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