Arterial blood culture to hasten the diagnosis of candidemia in critically ill patients

Tascini, Carlo; Sbrana, Francesco; Cardinali, Gianluigi; Ripoli, Andrea; Leonildi, Alessandro; Amadori, Francesco; Menichetti, Francesco

doi:10.1007/s00134-014-3336-2

Cited by 5 publications

(6 citation statements)

References 5 publications

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“…However, sensitivity of blood culture in the case of candidemia is around 50%. Recently, Tascini et al showed that cultures taken from arterial blood presented a shorter time to positivity with respect to blood cultures drawn from peripheral vein; it is noteworthy that the time sparing was around 12 h. However, no significant difference was documented in time to positivity for arterial blood and blood drawn from CVC [19].…”

mentioning

confidence: 98%

Treatment of invasive candidiasis: between guidelines and daily clinical practice

Tagliaferri

Menichetti

2015

Expert Review of Anti-infective Therapy

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mentioning

confidence: 98%

Treatment of invasive candidiasis: between guidelines and daily clinical practice

Tagliaferri

Menichetti

2015

Expert Review of Anti-infective Therapy

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“…In order to hasten microbiological diagnosis, blood cultures from an arterial line might reduce the time to confirmation of candidiasis especially in patients with few symptoms [50]. Source identification and control are necessary in patients with severe sepsis.…”

Section: Early Diagnosis or Exclusion Of Ic Requires Proper Microbiolmentioning

confidence: 99%

MEDical wards Invasive Candidiasis ALgorithms (MEDICAL):Consensus proposal for management

Scudeller

Bassetti

Concia

et al. 2016

European Journal of Internal Medicine

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Introduction A majority of invasive Candida infections occur in medical wards; however, evidence for management in this setting is scarce and based primarily on the intensive care or surgical setting. On behalf of the Italian Society for Anti-Infective Therapy (SITA) and the Italian Federation of Associations of Hospital Doctors on Internal Medicine (FADOI), the MEDICAL group produced practical management algorithms for patients in internal medicine wards. Methods The MEDICAL group panel, composed of 30 members from internal medicine, infectious disease, clinical pharmacology, clinical microbiology and clinical epidemiology, provided expert opinion through the RAND/UCLA method. Results Seven clinical scenarios were constructed based on clinical severity and probability of invasive candidiasis. For each scenario, the appropriateness of 63 different diagnostic, imaging, management, or therapeutic procedures was determined in two Delphi rounds. The necessity for performing each appropriate procedure, was then determined in a third Delphi round. Results were summarized in algorithms. Discussion The proposed algorithms provide internal medicine physicians and managers with an easy to interpret tool that is exhaustive, clear and suitable for adaption to individual local settings. Attention was paid to individual patient management and resource allocation

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“…Candida albicans was responsible for 50% (122 episodes) of total cases of candidemia while the nonalbicans species were represented by Candida parapsilosis 27% (65), Candida glabrata 12% (30), Candida tropicalis 5% (13) and Candida krusei 2.5% (6).…”

Section: Invasive Candidiasismentioning

confidence: 99%

“…showed that cultures taken from arterial blood presented a shorter time to positivity (TTP) with respect to blood cultures drawn from peripheral vein; it is noteworthy that the time sparing was around 12 h. However, no significant difference was documented in TTP for arterial blood and blood drawn from central venous catheter. 13 Serological methods for the diagnosis of invasive candidiasis include the combined detection of mannan antigen and anti-mannan antibodies and the b-glucan antigen. Mannan is a genus specific antigen produced by Candida in the early stages of the infection, but a lythic enzyme clears it rapidly from the serum.…”

Section: Invasive Candidiasismentioning

confidence: 99%

Appropriateness and cost-effectiveness in the treatment of invasive candidiasis in Internal Medicine Wards

Tagliaferri¹,

Menichetti²

2014

Ital J Med

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Invasive candidiasis (IC), including candidemia, is a major cause of morbidity and mortality among patients and the majority of cases of candidemia are documented in Medical Wards. Early identification of patients at risk, knowledge of local epidemiology and prompt efforts to define etiologic diagnosis are pivotal to ensure appropriateness. Start with an echinocandin and switch to fluconazole when possible, seems to represent a useful strategy for the management of IC. The choice between the three echinocandins should be based on the specific indications, pharmacokinetic/pharmacodynamic profile, clinical experience and cost.

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Arterial blood culture to hasten the diagnosis of candidemia in critically ill patients

Cited by 5 publications

References 5 publications

Treatment of invasive candidiasis: between guidelines and daily clinical practice

Treatment of invasive candidiasis: between guidelines and daily clinical practice

MEDical wards Invasive Candidiasis ALgorithms (MEDICAL):Consensus proposal for management

Appropriateness and cost-effectiveness in the treatment of invasive candidiasis in Internal Medicine Wards

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