Arterial baroreceptor reflex control of renal sympathetic nerve activity following chronic myocardial infarction in male, female, and ovariectomized female rats

Pinkham, Maximilian; Whalley, Gillian A.; Guild, Sarah-Jane; Malpas, Simon C.; Barrett, Carolyn J.

doi:10.1152/ajpregu.00026.2015

Cited by 7 publications

(10 citation statements)

References 64 publications

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“…In OVX group, MAP and HR were not altered; despite that this group had reduced BRS, similar results were observed by Pinkham et al . There were no changes in MAP or HR in OVX + MT group corroborating another study that demonstrated that replacement of testosterone did not increase blood pressure in hypogonadal men .…”

Section: Discussionsupporting

confidence: 87%

Low dose of methyltestosterone in ovariectomised rats improves baroreflex sensitivity without geno‐ and cytotoxicity

Terra

Lima

Nascimento

et al. 2016

Fundamemntal Clinical Pharma

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This study evaluated the effects of the isolated use of a low dose of methyltestosterone (MT) on cardiovascular reflexes and hormonal levels and its geno- and cytotoxic safety in ovariectomized rats. Female Wistar rats were divided into four groups (n = 6), respectively: SHAM (received vehicle methylcellulose 0.5%), SHAM + MT (received MT 0.05 mg/kg), OVX (received vehicle), and OVX + MT (received MT). Twenty-one days after ovariectomy, treatment was given orally daily for 28 days. The Bezold-Jarisch reflex (BJR) was analyzed by measuring the bradycardic and hypotensive responses elicited by phenylbiguanide (PBG) administration. The baroreflex sensitivity (BRS) was evaluated by phenylephrine and sodium nitroprussite. Myocyte hypertrophy was determined by morphometric analysis of H&E stained slides. Biochemical data were analyzed, as well as micronucleus assay. MT improved BRS and increased testosterone values, but did not change estradiol in the OVX group. MT did not promote changes in mean arterial pressure, heart rate, BJR, serum concentrations of troponin I, weight and histopathology of the heart. MT was able to restore the BRS in OVX rats. The geno- and cytotoxic safety of the MT was demonstrated by the absence of an increase in the micronucleus (PCEMN) or change in the ratio between normochromatic erythrocytes and polychromatic erythrocytes (NCE/PCE).

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Section: Discussionsupporting

confidence: 87%

Low dose of methyltestosterone in ovariectomised rats improves baroreflex sensitivity without geno‐ and cytotoxicity

Terra

Lima

Nascimento

et al. 2016

Fundamemntal Clinical Pharma

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“…The baroreflex system is devoted to maintaining cardiovascular homeostasis and preserving blood flow to vital organs (12). In MI, there appears to be a direct relationship between baroreflex sensitivity and survival, reduced survival having been reported in the setting of reduced baroreflex function (17,39). It is known that eNOS activity is impaired in endothelial cells exposed to native LDL (18).…”

Section: Discussionmentioning

confidence: 99%

Synthetic apolipoprotein A-I mimetic peptide 4F protects hearts and kidneys after myocardial infarction

Moreira

Irigoyen

Capcha

et al. 2020

American Journal of Physiology-Regulatory, Integrative and Comp

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Patients undergoing coronary angiography after myocardial infarction (MI) often develop cardiac and renal dysfunction. We hypothesized that the apolipoprotein A-I mimetic peptide 4F (4F) would prevent those complications. Male Wistar rats were fed a high-cholesterol diet for 8 days. The rats were then anesthetized with isoflurane and randomly divided into five groups: a control group (sham-operated rats), and four groups of rats induced to MI by left coronary artery ligation, the rats in three of those groups being injected 6 h later, with the nonionic contrast agent iopamidol, 4F, and iopamidol plus 4F, respectively. At postprocedure hour 24, we performed the following experiments/tests ( n = 8 rats/group): metabolic cage studies; creatinine clearance studies; analysis of creatinine, urea, sodium, potassium, triglycerides, total cholesterol, very low-, low- and high-density lipoproteins (VLDL, LDL, and HDL); immunohistochemistry; histomorphometry; Western blot analysis; and transmission electron microscopy. In another set of experiments ( n = 8 rats/group), also performed at postprocedure hour 24, we measured mean arterial pressure, heart rate, heart rate variability, echocardiographic parameters, left ventricular systolic pressure, and left ventricular end-diastolic pressure. 4F protected against MI-induced increases in total cholesterol, triglycerides, and LDL; increased HDL levels; reversed autonomic and cardiac dysfunction; decreased the myocardial ischemic area; minimized renal and cardiac apoptosis; protected mitochondria; and strengthened endothelia possibly by minimizing Toll-like receptor 4 upregulation (thus restoring endothelial nitric oxide synthase protein expression) and by upregulating vascular endothelial growth factor protein expression. 4F-treated animals showed signs of cardiac neovascularization. The nitric oxide-dependent cardioprotection and renoprotection provided by 4F could have implications for post-MI treatment.

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“…In the Lewis Polycystic Kidney rat model of CKD, reflexive renal sympathoinhibition following vagal nerve stimulation was blunted in females but not males (Salman et al, 2017). Work by the Barret group has demonstrated that biological sex influences baroreflex control of renal sympathetic nerve activity following myocardial infarction (Pinkham et al, 2015), and that female rats have attenuated renal sympathetic nerve activation in the minutes following myocardial infarction relative to males (Pinkham et al, 2012). These studies, along with the known contribution of biological sex towards autonomic control of blood pressure warrant further investigation into circadian autonomic control of renal function.…”

Section: Sex Differencesmentioning

confidence: 99%

Autonomic nerves and circadian control of renal function

Becker¹,

Zhang²,

Soliman³

et al. 2019

Autonomic Neuroscience

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Cardiovascular and renal physiology follow strong circadian rhythms. For instance, renal excretion of solutes and water is higher during the active period compared to the inactive period, and blood pressure peaks early in the beginning of the active period of both diurnal and nocturnal animals. The control of these rhythms is largely dependent on the expression of clock genes both in the central nervous system and within peripheral organs themselves. Although it is understood that the central and peripheral clocks interact and communicate, few studies have explored the specific mechanism by which various organ systems within the body are coordinated to control physiological processes. The renal sympathetic nervous innervation has long been known to have profound effects on renal function, and because the sympathetic nervous system follows strong circadian rhythms, it is likely that autonomic control of the kidney plays an integral role in modulating renal circadian function. This review highlights studies that provide insight into this interaction, discusses areas lacking clarity, and suggests the potential for future work to explore the role of renal autonomics in areas such as blood pressure control and chronic kidney disease.

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Arterial baroreceptor reflex control of renal sympathetic nerve activity following chronic myocardial infarction in male, female, and ovariectomized female rats

Cited by 7 publications

References 64 publications

Low dose of methyltestosterone in ovariectomised rats improves baroreflex sensitivity without geno‐ and cytotoxicity

Low dose of methyltestosterone in ovariectomised rats improves baroreflex sensitivity without geno‐ and cytotoxicity

Synthetic apolipoprotein A-I mimetic peptide 4F protects hearts and kidneys after myocardial infarction

Autonomic nerves and circadian control of renal function

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