Artemisinin Improves Acetylcholine-Induced Vasodilatation in Rats with Primary Hypertension

Liu, Xuanxuan; Wang, Xingxing; Yan, Pan; Zhao, Li; Sun, Shuhong; Luo, Ang; Bao, Changlei; Tang, Haiyang; Han, Ying

doi:10.2147/dddt.s330721

Cited by 8 publications

(5 citation statements)

References 48 publications

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“…This study did not demonstrate a significant effect on reduction in insulin resistance. Second, human and in-silico studies have reported antihypertensive effects of Artemisia spp extracts, primarily through angiotensin converting enzyme 1 (ACE-1) inhibition [7,30]. However, this study found weak evidence to this end.…”

Section: Discussionmentioning

confidence: 67%

Effectiveness of Jena DM® Herbal Formulation as Complementary Therapy to Conventional Oral Hypoglycemic Agents in Type-2 Diabetes Mellitus: A Quasi-experimental Study

Kiptoo,

Mekuriya Yadesa,

Ajayi

et al. 2024

Cureus

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Section: Discussionmentioning

confidence: 67%

Effectiveness of Jena DM® Herbal Formulation as Complementary Therapy to Conventional Oral Hypoglycemic Agents in Type-2 Diabetes Mellitus: A Quasi-experimental Study

Kiptoo,

Mekuriya Yadesa,

Ajayi

et al. 2024

Cureus

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“…SNP is the direct donor of NO, which has the powerful function of relaxing the vascular smooth muscle as well as anti-inflammatory and anti-platelet aggregation [ 20 ]. ACH (acetylcholine) promotes the release of NO from vascular endothelial cells, which leads to the relaxation of adjacent smooth muscle cells [ 21 ]. Therefore, ACH is an endothelium-dependent vasodilator while SNP is non-endothelium-dependent.…”

Section: Resultsmentioning

confidence: 99%

Leonurine Attenuates Obesity-Related Vascular Dysfunction and Inflammation

Shi

Zhang

et al. 2022

Antioxidants

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Oxidative stress in adipose tissue is a crucial pathogenic mechanism of obesity-associated cardiovascular diseases. Chronic low-grade inflammation caused by obesity increases ROS production and dysregulation of adipocytokines. Leonurine (LEO) is an active alkaloid extracted from Herba Leonuri and plays a protective role in the cardiovascular system. The present study tested whether LEO alleviates inflammation and oxidative stress, and improves vascular function in an obese mouse model. Here, we found that obesity leads to inflammation and oxidative stress in epididymal white adipose tissue (EWAT), as well as vascular dysfunction. LEO significantly improved inflammation and oxidative stress both in vivo and in vitro. Obesity-induced vascular dysfunction was also improved by LEO as evidenced by the ameliorated vascular tone and decreased mesenteric artery fibrosis. Using mass spectrometry, we identified YTHDF1 as the direct target of LEO. Taken together, we demonstrated that LEO improves oxidative stress and vascular remodeling induced by obesity and targets YTHDF1, raising the possibility of LEO treating other obesity-related metabolic syndromes.

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“…ART administration to diabetic rats’ alleviated ECG changes that appeared in untreated diabetic rats. The improved cardiac function with ART application probably resulted from the improvement in coronary artery endothelium-dependent relaxation and increased myocardial blood supply 23 .…”

Section: Discussionmentioning

confidence: 99%

Artemisinin attenuates type 2 diabetic cardiomyopathy in rats through modulation of AGE-RAGE/HMGB-1 signaling pathway

Farrag

Hammad

Safwat

et al. 2023

Sci Rep

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Diabetes mellitus is a common metabolic disorder. About two-thirds of diabetic patients develop diabetic cardiomyopathy (DCM), which becomes a challenging issue as it severely threatens the patient’s life. Hyperglycemia and the resulting advanced glycated end products (AGE) and their receptor (RAGE)/High Mobility Group Box-1 (HMGB-1) molecular pathway are thought to be key players. Recently, artemisinin (ART) has gained more attention owing to its potent biological activities beyond its antimalarial effect. Herein, we aim to evaluate the effect of ART on DCM and the possible underlying mechanisms. Twenty-four male Sprague–Dawley rats were divided into: control, ART, type 2 diabetic and type 2 diabetic treated with ART groups. At the end of the research, the ECG was recorded, then the heart weight to body weight (HW/BW) ratio, fasting blood glucose, serum insulin and HOMA-IR were evaluated. Cardiac biomarkers (CK-MB and LDH), oxidative stress markers, IL-1β, AGE, RAGE and HMGB-1 expression were also measured. The heart specimens were stained for H&E as well as Masson’s trichrome. DCM induced disturbances in all studied parameters; contrary to this, ART improved these insults. Our study concluded that ART could improve DCM through modulation of the AGE-RAGE/HMGB-1 signaling pathway, with subsequent impacts on oxidative stress, inflammation and fibrosis. ART could therefore be a promising therapy for the management of DCM.

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Artemisinin Improves Acetylcholine-Induced Vasodilatation in Rats with Primary Hypertension

Cited by 8 publications

References 48 publications

Effectiveness of Jena DM® Herbal Formulation as Complementary Therapy to Conventional Oral Hypoglycemic Agents in Type-2 Diabetes Mellitus: A Quasi-experimental Study

Effectiveness of Jena DM® Herbal Formulation as Complementary Therapy to Conventional Oral Hypoglycemic Agents in Type-2 Diabetes Mellitus: A Quasi-experimental Study

Leonurine Attenuates Obesity-Related Vascular Dysfunction and Inflammation

Artemisinin attenuates type 2 diabetic cardiomyopathy in rats through modulation of AGE-RAGE/HMGB-1 signaling pathway

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