“…Since then, semisynthetic derivatives of artemisinin have been gradually developed, including artesunate, artemether, dihydroartemisinin, artelinic acid, and arteether, all of which show great promise in the treatment of malaria (Klayman, 1985;Teja-Isavadharm et al, 2010;Morris et al, 2011;Morris et al, 2013) (Figure 1). As research has progressed, the effects of artemisinin and its derivatives have been greatly extended, and these compounds are widely used in antitumor (Verma et al, 2017;Wang et al, 2017;Wei and Liu, 2017), antifibrosis (Cao et al, 2016;Wang et al, 2019a), immunosuppressive (Li et al, 2013;Hou and Huang, 2016), antivirus (Sharma et al, 2014), antiatherosclerosis (Du et al, 2019;Jiang et al, 2020), antiobesity (Lu et al, 2016), and antidiabetes (Ho et al, 2014) treatments. Recently, increasing evidence has shown that artemisinins have significant therapeutic effects on metabolic diseases, especially diabetes, obesity, and hypercholesterolemia.…”