Artemisinin, a potential option to inhibit inflammation and angiogenesis in rosacea

Yuan, Xin; Li, Ji; Li, Yangfan; Deng, Zhili; Zhou, Lei; Long, Juan; Tang, Yan; Zuo, Zhihong; Zhang, Yiya; Xie, Hongfu

doi:10.1016/j.biopha.2019.109181

Cited by 58 publications

(49 citation statements)

References 29 publications

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“…Wang et al [ 36 ] reported that artemisinin pretreatment potently inhibited IL-6 and TNF-αrelease induced by LPS in RAW264.7 cells, and artemisinin synergized with antibiotics to protect against LPS challenge by decreasing pro-inflammatory cytokine release. Yuan et al [ 37 ] reported that proinflammatory factor levels (IL-1β, IL-6, TNF-α) and TLR-2 were significantly ameliorated by artemisinin treatment in LL37-induced rosacea-like mice, and artemisinin significantly decreased the LL37-induced expression of inflammatory biomarkers via the NF-κB signaling pathway in HaCaT cells. Li et al [ 38 ] also reported that dihydroarteannuin can strongly reduce TNF-α levels in the culture supernatant of peritoneal macrophages and the serum of BXSB mice in vitro and in vivo, and the inhibitory effects on TNF-α production resulted from blockade of the NF-κB signaling pathway upstream of IκB degradation.…”

Section: Discussionmentioning

confidence: 99%

Artemisinin Protects Porcine Mammary Epithelial Cells against Lipopolysaccharide-Induced Inflammatory Injury by Regulating the NF-κB and MAPK Signaling Pathways

Zhang

Xiong

Chen

et al. 2021

Animals

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Artemisinin performs a variety of biological functions, such as anti-cancer, anti-inflammatory, anti-viral, and anti-oxidant effects. However, the effects of artemisinin on sow mastitis have not been studied. The results of the current study showed that mRNA expression abundance and content of the inflammatory factors interleukin-1β (IL-1β), tumor necrosis factor α (TNF-α), and interleukin-6 (IL-6) were significantly increased when using 50 μg/mL LPS to stimulate pMECs for 24 h (p < 0.05). Pretreatment with 20 μM artemisinin weakened LPS-induced inflammatory damage in pMECs and decreased mRNA expression abundance and the content of inflammatory factors (IL-1β, IL-6, and TNF-α) in pMECs (p < 0.05). Mechanistically, artemisinin inhibited LPS-induced activation of the mitogen-activated protein kinase (MAPK) and nuclear factor-κB (NF-κB) signaling pathways. In summary, the pretreatment of pMECs with artemisinin showed enhanced anti-inflammatory activity against LPS-induced inflammation.

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Section: Discussionmentioning

confidence: 99%

Artemisinin Protects Porcine Mammary Epithelial Cells against Lipopolysaccharide-Induced Inflammatory Injury by Regulating the NF-κB and MAPK Signaling Pathways

Zhang

Xiong

Chen

et al. 2021

Animals

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“…16 Several approaches of anti-inflammation and anti-angiogenesis treatment improve the symptoms. [17][18][19][20] Previous reports have shown an association between rosacea and numerous systemic diseases, such as cardiovascular, gastrointestinal, neurological and autoimmune diseases, and cancers. 21 Our results have confirmed that breast cancer and hypertension may be associated with rosacea in females.…”

Section: Discussionmentioning

confidence: 99%

“…heat, UV‐B, stress, Demodex , bacteria) may have a triggering role 16 . Several approaches of anti‐inflammation and anti‐angiogenesis treatment improve the symptoms 17‐20 . Previous reports have shown an association between rosacea and numerous systemic diseases, such as cardiovascular, gastrointestinal, neurological and autoimmune diseases, and cancers 21 .…”

Section: Discussionmentioning

confidence: 99%

Epidemiological features of rosacea in Changsha, China: A population‐based, cross‐sectional study

Wang

Deng

et al. 2020

The Journal of Dermatology

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Rosacea is a common chronic skin disorder of unknown etiology. While population prevalence rates range 0.2-22% in Europe and North America, prevalence in China is currently undetermined. We conducted a large populationbased case-control study to determine the present epidemiological status of rosacea in China, involving 10 095 participants aged 0-100 years (mean age, 35.5 ± 19.1; 50.5% female). A census of rosacea among 15 communities in Changsha in south central China was conducted with skin examination by board-certified dermatologists. Rosacea was observed in 3.48% (95% confidence interval, 3.13-3.85%) of the study population. Subtype distribution was erythematotelangiectatic in 47.6%, papulopustular in 35.0% and phymatous in 17.4%. Family history was noted in 37.8% and ocular symptoms in 31.3%. Associations with rosacea were observed for melasma, hypertension, hyperthyroidism and breast cancer in females (P < 0.05), and also for hyperthyroidism and peptic ulcers in males (P < 0.05). Our results provide baseline information about epidemiological aspects of rosacea in China.

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“…In our patients, it can be assumed that the increased release of dominant mediators leads to damage of the facial tissue and the development of rosacea. This is proved by the other scientists who have indicated the role of long-term trigger factors in the development of abnormal immune system responses [31].…”

Section: Discussionmentioning

confidence: 87%

Characterization of Pro- and Anti-Inflammatory Tissue Factors in Rosacea: A Pilot study

et al. 2020

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Rosacea is a chronic inflammatory skin disease mainly affecting the facial skin. Our aim was to determine the appearance of pro- and anti- inflammatory cytokines in rosacea-affected facial tissue. Materials and Methods: Rosacea tissue were obtained from eight patients (aged 35 to 50 years). The control group (CG) included four facial skin samples (49 to 70 years). Routine staining and immunohistochemistry for IL-1, IL-10, LL-37, HBD-2, and HBD-4 proceeded. Results: Inflammation was observed in all the rosacea samples. A statistically significant difference was seen between epithelial HBD-2 positive cells in comparison to the control. There was a strong positive correlation between HBD-4 in the epithelium and HBD-4 in the connective tissue, IL-10 in the epithelium and IL-1 in the connective tissue, and IL-1 in the epithelium and IL-10 in the connective tissue. Conclusion: Increased levels of IL-10 and decreased levels of IL-1 show the balance between anti- and pro-inflammatory tissue responses. A significant amount of HBD-2 in the epithelium proves its important role in the local immune response of rosacea-affected tissue. The last effect seems to be intensified by the elevated level of LL-37 in the epithelium.

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Artemisinin, a potential option to inhibit inflammation and angiogenesis in rosacea

Cited by 58 publications

References 29 publications

Artemisinin Protects Porcine Mammary Epithelial Cells against Lipopolysaccharide-Induced Inflammatory Injury by Regulating the NF-κB and MAPK Signaling Pathways

Artemisinin Protects Porcine Mammary Epithelial Cells against Lipopolysaccharide-Induced Inflammatory Injury by Regulating the NF-κB and MAPK Signaling Pathways

Epidemiological features of rosacea in Changsha, China: A population‐based, cross‐sectional study

Characterization of Pro- and Anti-Inflammatory Tissue Factors in Rosacea: A Pilot study

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