Artemisinin: A Panacea Eligible for Unrestrictive Use?

Yuan, Dongsheng; Chen, Yanping; Tan, Lili; Huang, Suli; Li, Changqing; Wang, Qi; Zeng, Quan

doi:10.3389/fphar.2017.00737

Cited by 7 publications

(4 citation statements)

References 31 publications

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“…In support of this possibility are results from studies showing that artemisinin and its analogs can alleviate inflammatory responses of diabetic nephropathy, reduce urinary albumin and diminish the development of diabetic nephropathy. 32,33 We next designed an experiment to examine the effect of ATM on diabetic nephropathy and found that ATM significantly reduced urinary albumin in mice, which is consistent with previous studies. The basis for ATM to significantly reduce the amount of urine remains unknown and will require further research.…”

Section: Discussionsupporting

confidence: 80%

<p>Artemether Regulates Metaflammation to Improve Glycolipid Metabolism in db/db Mice</p>

et al. 2020

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Background: Artemether, a commonly used artemisinin derivative, has been shown to possess potential antidiabetic activities. However, only limited information is available on the mechanisms of artemether in type 2 diabetes. Therefore, in this study, we examined some of the possible mechanisms of artemether (ATM) upon glycolipid metabolism in the db/db mouse model of diabetes. Materials and Methods: Male C57BL/KsJ-db/db and C57BL/KsJ-db/+ mice at 4 weeks of age were divided into four groups (N=6/group): ( 1) NC (normal controldb/+ mice, 1% methylcellulose, intragastric administration), ( 2) DM (diabetic modeldb/db mice, 1% methylcellulose, intragastric administration), (3) ATM 100 (DM + 100 mg/kg of artemether) and ( 4) ATM 200 (DM + 200 mg/kg of artemether). A number of assays related to diabetes were then performed following a 4-week period of these treatments.Results: Artemether at both doses significantly reduced rates of weight gain and fasting blood glucose levels, improved islet function and insulin resistance and reduced serum lipid levels to varying degrees in db/db mice. Artemether exerted a positive effect on islet vacuolar degeneration and hepatic steatosis, and increased expressions of AMP-activated protein kinase, glucose transporter 4 and Insulin receptor β protein in the liver of these db/db mice. With the use of liver protein chip detection, we found that artemether significantly improved the immune microenvironment, downregulated the expression of inflammatory factors and activated the cytokine-mediated signaling pathway through cytokine-cytokine receptor interactions. Conclusion:Artemether may regulate glycolipid metabolism in db/db mice by improving the immune microenvironment. The results of this study provide important new information that can serve as the foundation for future research into the use of artemether as a means to improve glycolipid metabolism.

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Section: Discussionsupporting

confidence: 80%

<p>Artemether Regulates Metaflammation to Improve Glycolipid Metabolism in db/db Mice</p>

et al. 2020

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“…The investigation of the biological activity of Artemisia species and their constituents is required to explore the full potential of diverse Artemisia species and their chemical ingredients against cancer, malaria, and infections [42]. Artemisinin can also exert beneficial effects in treatment of the wide-spectrum diseases such as obesity, diabetes, and aging-related disorders [43].…”

Section: Introductionmentioning

confidence: 99%

Assessment of Artemisinin Contents in Selected Artemisia Species from Tajikistan (Central Asia)

et al. 2019

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Background: Central Asia is the center of origin and diversification of the Artemisia genus. The genus Artemisia is known to possess a rich phytochemical diversity. Artemisinin is the shining example of a phytochemical isolated from Artemisia annua, which is widely used in the treatment of malaria. There is great interest in the discovery of alternative sources of artemisinin in other Artemisia species. Methods: The hexane extracts of Artemisia plants were prepared with ultrasound-assisted extraction procedures. Silica gel was used as an adsorbent for the purification of Artemisia annua extract. High-performance liquid chromatography with ultraviolet detection was performed for the quantification of underivatized artemisinin from hexane extracts of plants. Results: Artemisinin was found in seven Artemisia species collected from Tajikistan. Content of artemisinin ranged between 0.07% and 0.45% based on dry mass of Artemisia species samples. Conclusions: The artemisinin contents were observed in seven Artemisia species. A. vachanica was found to be a novel plant source of artemisinin. Purification of A. annua hexane extract using silica gel as adsorbent resulted in enrichment of artemisinin.

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“…Presently, extensive in vitro and in vivo preclinical data support the therapeutic efficacy of artemisinins in a variety of human disease conditions beyond malaria, such as cancer, diabetes, atherosclerosis, viral infections, autoimmune diseases and, not least, in neurodegenerative diseases [49]. These effects seem to be mediated by artemisininsinduced changes in several signaling pathways, that interfere with multiple hallmarks of the respective diseases and probably rely on multitarget and promiscuous interactions of artemisinins with cellular proteins [50]. However, the exact molecules and substances that directly interact with artemisinins have yet to be determined.…”

Section: Artemisinins: Chemical Structure Pharmacokinetic Behaviors A...mentioning

confidence: 99%

Another Use for a Proven Drug: Experimental Evidence for the Potential of Artemisinin and Its Derivatives to Treat Alzheimer’s Disease

Kiss,

Kins,

Gorgas

et al. 2024

IJMS

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Plant-derived multitarget compounds may represent a promising therapeutic strategy for multifactorial diseases, such as Alzheimer’s disease (AD). Artemisinin and its derivatives were indicated to beneficially modulate various aspects of AD pathology in different AD animal models through the regulation of a wide range of different cellular processes, such as energy homeostasis, apoptosis, proliferation and inflammatory pathways. In this review, we aimed to provide an up-to-date overview of the experimental evidence documenting the neuroprotective activities of artemi-sinins to underscore the potential of these already-approved drugs for treating AD also in humans and propose their consideration for carefully designed clinical trials. In particular, the benefits to the main pathological hallmarks and events in the pathological cascade throughout AD development in different animal models of AD are summarized. Moreover, dose- and context-dependent effects of artemisinins are noted.

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Artemisinin: A Panacea Eligible for Unrestrictive Use?

Cited by 7 publications

References 31 publications

<p>Artemether Regulates Metaflammation to Improve Glycolipid Metabolism in db/db Mice</p>

<p>Artemether Regulates Metaflammation to Improve Glycolipid Metabolism in db/db Mice</p>

Assessment of Artemisinin Contents in Selected Artemisia Species from Tajikistan (Central Asia)

Another Use for a Proven Drug: Experimental Evidence for the Potential of Artemisinin and Its Derivatives to Treat Alzheimer’s Disease

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