2019
DOI: 10.3746/pnf.2019.24.3.299
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Artemisia princeps Inhibits Adipogenic Differentiation of 3T3-L1 Pre-Adipocytes via Downregulation of PPARγ and MAPK Pathways

Abstract: Artemisia princeps, the Korean mugwort, is an edible plant that has various beneficial effects on health, and which has been used as a part of traditional folk medicine. The current study investigated the possible effects of solvent (H2O, n-BuOH, 85% aq. MeOH, and n-hexane) partitioned fractions of A. princeps crude extract (APE) on adipogenic differentiation of 3T3-L1 mouse pre-adipocytes. Characteristics of the differentiated adipocytes were evaluated by Oil red O staining of intracellular lipid droplets, an… Show more

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Cited by 22 publications
(28 citation statements)
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“…Previous studies showed that A. princeps extract exerted antiadipogenesis effects in 3T3-L1 murine preadipocyte cell line. 12,13 It was reported that A. princeps inhibited the adipocyte differentiation via antioxidative activity and MAPK pathway suppression. These studies have supported the current results although they were conducted in immortalized mouse preadipocytes.…”
Section: Discussionmentioning
confidence: 99%
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“…Previous studies showed that A. princeps extract exerted antiadipogenesis effects in 3T3-L1 murine preadipocyte cell line. 12,13 It was reported that A. princeps inhibited the adipocyte differentiation via antioxidative activity and MAPK pathway suppression. These studies have supported the current results although they were conducted in immortalized mouse preadipocytes.…”
Section: Discussionmentioning
confidence: 99%
“…MeOH solvent fraction of A. princeps extract was prepared as described earlier. 12 Chemical structure and characterization of the compound 1 were carried out by 1 H and 13 C NMR, and comparison of spectral data with published literature was also carried out ( Fig. 1A).…”
Section: Methodsmentioning
confidence: 99%
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“…In Western and African folk medicine, several species of the genus Artemisia are used for their claimed healing properties and for the cure of specific ailments. The early in vitro antiobesity-effects [ 135 ] of Artemisia could be due to the presence of active compounds, such as terpenes, steroids, and saponins, and also the active ingredients, such as tannins and flavonoids [ 136 ]. Physalis alkekengi , also referred to as ground cherry, is an indigenous herb in Iran and many other regions of Asia such as China.…”
Section: Anti-obesity Properties Of Polyphenolsmentioning
confidence: 99%