Artemisia argyi extract induces apoptosis in human gemcitabine-resistant lung cancer cells via the PI3K/MAPK signaling pathway

Su, San-Hua; Sundhar, Navaneethan; Kuo, Wei‐Wen; Lai, Shang-Chih; Kuo, Chia‐Hua; Ho, Tsung‐Jung; Lin, Pi‐Yu; Lin, Shinn‐Zong; Shih, Cheng Yen; Lin, Yu‐Jung; Huang, Chih‐Yang

doi:10.1016/j.jep.2022.115658

Cited by 25 publications

(14 citation statements)

References 50 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The water extract of Artemisia argyi was observed to decrease cell proliferation, induce apoptosis, and augment the toxicity of chemotherapies in lung cancer cells. 67 In addition to chemotherapy, our results revealed that treatment with Artemisia argyi and its active compounds, eriodictyol and umbelliferone, repressed the proliferation of HER2-positive SKBr-3 breast cancer cells (Figure 6). Furthermore, eriodictyol treatment exhibited a notable reduction in cell growth even in lapatinib-resistant SKBr-3 breast cancer cells (Figure 7).…”

Section: Discussionmentioning

confidence: 84%

Artemisia argyi extracts overcome lapatinib resistance via enhancing TMPRSS2 activation in HER2‐positive breast cancer

Ho,

Wei,

Zhao

et al. 2024

Environmental Toxicology

View full text Add to dashboard Cite

Breast cancer stands as the predominant malignancy and primary cause of cancer‐related mortality among females globally. Approximately 25% of breast cancers exhibit HER2 overexpression, imparting a more aggressive tumor phenotype and correlating with poor prognoses. Patients with metastatic breast cancer receiving HER2 tyrosine kinase inhibitors (HER2 TKIs), such as Lapatinib, develop acquired resistance within a year, posing a critical challenge in managing this disease. Here, we explore the potential of Artemisia argyi, a Chinese herbal medicine known for its anti‐cancer properties, in mitigating HER2 TKI resistance in breast cancer. Analysis of the Cancer Genome Atlas (TCGA) revealed diminished expression of transmembrane serine protease 2 (TMPRSS2), a subfamily of membrane proteolytic enzymes, in breast cancer patients, correlating with unfavorable outcomes. Intriguingly, lapatinib‐responsive patients exhibited higher TMPRSS2 expression. Our study unveiled that the compounds from Artemisia argyi, eriodictyol, and umbelliferone could inhibit the growth of lapatinib‐resistant HER2‐positive breast cancer cells. Mechanistically, they suppressed HER2 kinase activation by enhancing TMPRSS2 activity. Our findings propose TMPRSS2 as a critical determinant in lapatinib sensitivity, and Artemisia argyi emerges as a potential agent to overcome lapatinib via activating TMPRSS2 in HER2‐positive breast cancer. This study not only unravels the molecular mechanisms driving cell death in HER2‐positive breast cancer cells induced by Artemisia argyi but also lays the groundwork for developing novel inhibitors to enhance therapy outcomes.

show abstract

Section: Discussionmentioning

confidence: 84%

Artemisia argyi extracts overcome lapatinib resistance via enhancing TMPRSS2 activation in HER2‐positive breast cancer

Ho,

Wei,

Zhao

et al. 2024

Environmental Toxicology

View full text Add to dashboard Cite

show abstract

“…AA and OC are popular herbal medicines in Southeast Asia. This plant extract has been used as an anti‐cancer, anti‐apoptotic, and anti‐aging agent and for Parkinson's disease treatments 12,14,40–42 . ISL drug has also been used against multiple diseases such as cardiomyopathy and intracerebral hemorrhage 43,44 .…”

Section: Discussionmentioning

confidence: 99%

“…This plant extract has been used as an anti-cancer, antiapoptotic, and anti-aging agent and for Parkinson's disease treatments. 12,14,[40][41][42] ISL drug has also been used against multiple diseases such as cardiomyopathy and intracerebral hemorrhage. 43,44 To the A previous study demonstrated that DOX-induced cardiac failure is important in hypertrophy-related signaling pathways, including GATA-4, ANP, and BNP.…”

Section: Isl Combined With Water Extract Of Aa and Oc Protects Agains...mentioning

confidence: 99%

“…9 Ohwia caudata (OC) and Artemisia argyi (AA) are shrubs endogenous to Asian subcontinental countries, including China, Japan, Taiwan, Hong Kong, Korea, Russia, India, and some African countries. [10][11][12][13][14] According to previous literature, Ohwia caudata (OC) and Artemisia argyi (AA) locally called chinse herbal medicines derived from these plants are used to treat several common human diseases, including bacillary dysentery and rheumatic arthritis which is known as folk medicine. Ohwia caudata (OC) belongs to the Fabaceae family under the genus Ohwia formally Desmodium (Desmodium caudatum).…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

A combination of isoliquiritigenin with Artemisia argyi and Ohwia caudata water extracts attenuates oxidative stress, inflammation, and apoptosis by modulating Nrf2/Ho‐1 signaling pathways in SD rats with doxorubicin‐induced acute cardiotoxicity

Yuan Hsieh,

Islam,

Kuo

et al. 2023

Environmental Toxicology

Self Cite

View full text Add to dashboard Cite

Ohwia caudata (Thunb.) H. Ohashi (Leguminosae) also called as “Evergreen shrub” and Artemisia argyi H.Lév. and Vaniot (Compositae) also named as “Chinese mugwort” those two‐leaf extracts frequently used as herbal medicine, especially in south east Asia and eastern Asia. Anthracyclines such as doxorubicin (DOX) are commonly used as effective chemotherapeutic drugs in anticancer therapy around the world. However, chemotherapy‐induced cardiotoxicity, dilated cardiomyopathy, and congestive heart failure are seen in patients who receive DOX therapy, with the mechanisms underlying DOX‐induced cardiac toxicity remaining unclear. Mitochondrial dysfunction, oxidative stress, inflammatory response, and cardiomyocytes have been shown to play crucial roles in DOX‐induced cardiotoxicity. Isoliquiritigenin (ISL, 10 mg/kg) is a bioactive flavonoid compound with protective effects against inflammation, neurodegeneration, cancer, and diabetes. Here, in this study, our aim is to find out the Artemisia argyi (AA) and Ohwia caudata (OC) leaf extract combination with Isoliquiritigenin in potentiating and complementing effect against chemo drug side effect to ameliorate cardiac damage and improve the cardiac function. In this study, we showed that a combination of low (AA 300 mg/kg; OC 100 mg/kg) and high‐dose(AA 600 mg/kg; OC 300 mg/kg) AA and OC water extract with ISL activated the cell survival‐related AKT/PI3K signaling pathway in DOX‐treated cardiac tissue leading to the upregulation of the antioxidant markers SOD, HO‐1, and Keap‐1 and regulated mitochondrial dysfunction through the Nrf2 signaling pathway. Moreover, the water extract of AA and OC with ISL inhibited the inflammatory response genes IL‐6 and IL‐1β, possibly through the NFκB/AKT/PI3K/p38α/NRLP3 signaling pathways. The water extract of AA and OC with ISL could be a potential herbal drug treatment for cardiac hypertrophy, inflammatory disease, and apoptosis, which can lead to sudden heart failure.

show abstract

“…The Artemisia genus and the member species are well-studied for their various biological activities [ 8 , 9 , 10 , 11 , 12 , 13 ]. Artemisia annua L. has demonstrated significant medicinal benefits because of the presence of artemisinin [ 14 ].…”

Section: Introductionmentioning

confidence: 99%

Phytochemical Composition and In Vitro Antioxidant, Anti-Inflammatory, Anticancer, and Enzyme-Inhibitory Activities of Artemisia nilagirica (C.B. Clarke) Pamp

Albaqami

Benny²,

Hamdi

et al. 2022

Molecules

View full text Add to dashboard Cite

Plants have been employed in therapeutic applications against various infectious and chronic diseases from ancient times. Various traditional medicines and folk systems have utilized numerous plants and plant products, which act as sources of drug candidates for modern medicine. Artemisia is a genus of the Asteraceae family with more than 500 species; however, many of these species are less explored for their biological efficacy, and several others are lacking scientific explanations for their uses. Artemisia nilagirica is a plant that is widely found in the Western Ghats, Kerala, India and is a prominent member of the genus. In the current study, the phytochemical composition and the antioxidant, enzyme-inhibitory, anti-inflammatory, and anticancer activities were examined. The results indicated that the ethanol extract of A. nilagirica indicated in vitro DPPH scavenging (23.12 ± 1.28 µg/mL), ABTS scavenging (27.44 ± 1.88 µg/mL), H2O2 scavenging (12.92 ± 1.05 µg/mL), and FRAP (5.42 ± 0.19 µg/mL). The anti-inflammatory effect was also noticed in the Raw 264.7 macrophages, where pretreatment with the extract reduced the LPS-stimulated production of cytokines (p < 0.05). A. nilagirica was also efficient in inhibiting the activities of α-amylase (38.42 ± 2.71 µg/mL), α-glucosidase (55.31 ± 2.16 µg/mL), aldose reductase (17.42 ± 0.87 µg/mL), and sorbitol dehydrogenase (29.57 ± 1.46 µg/mL). It also induced significant inhibition of proliferation in breast (MCF7 IC50 = 41.79 ± 1.07, MDAMB231 IC50 = 55.37 ± 2.11µg/mL) and colon (49.57 ± 1.46 µg/mL) cancer cells. The results of the phytochemical screening indicated a higher level of polyphenols and flavonoids in the extract and the LCMS analysis revealed the presence of various bioactive constituents including artemisinin.

show abstract

Artemisia argyi extract induces apoptosis in human gemcitabine-resistant lung cancer cells via the PI3K/MAPK signaling pathway

Cited by 25 publications

References 50 publications

Artemisia argyi extracts overcome lapatinib resistance via enhancing TMPRSS2 activation in HER2‐positive breast cancer

Artemisia argyi extracts overcome lapatinib resistance via enhancing TMPRSS2 activation in HER2‐positive breast cancer

A combination of isoliquiritigenin with Artemisia argyi and Ohwia caudata water extracts attenuates oxidative stress, inflammation, and apoptosis by modulating Nrf2/Ho‐1 signaling pathways in SD rats with doxorubicin‐induced acute cardiotoxicity

Phytochemical Composition and In Vitro Antioxidant, Anti-Inflammatory, Anticancer, and Enzyme-Inhibitory Activities of Artemisia nilagirica (C.B. Clarke) Pamp

Contact Info

Product

Resources

About