Artemisia and Artemisia-based products for COVID-19 management: current state and future perspective

Orege, Joshua Iseoluwa; Adeyemi, Sherif Babatunde; Tiamiyu, Bashir B.; Akinyemi, Toluwanimi Oluwadara; Ajibola, Ibrahim Yusuf; Orege, Odunola Blessing

doi:10.1007/s13596-021-00576-5

Cited by 18 publications

(17 citation statements)

References 51 publications

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“…Interestingly, artemisinin and its derivatives also regulate multiple immune cells, including macrophages, monocytes, dendritic cells, and T cells to inhibit proinflammatory cytokine release and cytokine storm outbreak [108]. More clinical studies need to be conducted to provide further therapeutic protocols to substantiate the safety and efficacy of Artemisia either in monotherapeutic form or as combination therapies with existing drugs [109,110].…”

Section: Artemisinin and Artemisinins' Potential In Management Of Cov...mentioning

confidence: 99%

“…While extracts from Artemisia plants have shown efficacy in small-scale clinical trials, these have not clarified whether a specific chemical constituent is responsible or whether the effect is due to a synergistic antiviral effect of several compounds [109]. A recent study suggested that the antiviral and immunomodulation effects of Artemisia extracts may not only be due to artemisinin, but also to other potentially identified and/or unidentified bioactive compounds [20].…”

Section: Artemisinin and Artemisinins' Potential In Management Of Cov...mentioning

confidence: 99%

“…The World Health Organization (WHO) has recommended the use of artemisininbased combination therapies (ACTs) in the treatment of malaria (artemether-lumefantrine, artesunate-amodiaquine, dihydroartemisinin-piperaquine, and artesunate-mefloquine). Amodiaquine and mefloquine, two quinoline ACT partners, were active in vitro at micromolar concentrations against SARS-CoV-1 at 2.5 mM and SARS-CoV-2 at 10 mM, respectively [104,109]. The use of ACTs in malaria-endemic areas of Africa perhaps explains the later emergence and less serious impact of COVID-19 in those areas [111].…”

Section: Artemisinin-based Combination Therapies (Acts)mentioning

confidence: 99%

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RETRACTED: Artemisia Extracts and Artemisinin-Based Antimalarials for COVID-19 Management: Could These Be Effective Antivirals for COVID-19 Treatment?

Agrawal¹,

Agrawal²,

Blunden

2022

Molecules

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As the world desperately searches for ways to treat the coronavirus disease 2019 (COVID-19) pandemic, a growing number of people are turning to herbal remedies. The Artemisia species, such as A. annua and A. afra, in particular, exhibit positive effects against severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) infection and COVID-19 related symptoms. A. annua is a source of artemisinin, which is active against malaria, and also exhibits potential for other diseases. This has increased interest in artemisinin’s potential for drug repurposing. Artemisinin-based combination therapies, so-called ACTs, have already been recognized as first-line treatments against malaria. Artemisia extract, as well as ACTs, have demonstrated inhibition of SARS-CoV-2. Artemisinin and its derivatives have also shown anti-inflammatory effects, including inhibition of interleukin-6 (IL-6) that plays a key role in the development of severe COVID-19. There is now sufficient evidence in the literature to suggest the effectiveness of Artemisia, its constituents and/or artemisinin derivatives, to fight against the SARS-CoV-2 infection by inhibiting its invasion, and replication, as well as reducing oxidative stress and inflammation, and mitigating lung damage.

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Section: Artemisinin and Artemisinins' Potential In Management Of Cov...mentioning

confidence: 99%

Section: Artemisinin and Artemisinins' Potential In Management Of Cov...mentioning

confidence: 99%

Section: Artemisinin-based Combination Therapies (Acts)mentioning

confidence: 99%

See 1 more Smart Citation

RETRACTED: Artemisia Extracts and Artemisinin-Based Antimalarials for COVID-19 Management: Could These Be Effective Antivirals for COVID-19 Treatment?

Agrawal¹,

Agrawal²,

Blunden

2022

Molecules

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“…While extracts from medicinal plants may show some preliminary efficacy in small scale clinical trials ( Dong et al, 2020 ; reviewed in Orege et al, 2021 ), these do not clarify where the activity is coming from. For instance, the antiviral and immunomodulation effects of Artemisia spp.…”

Section: Artemisinins: Potentials In Combating Covid-19 and Other Hum...mentioning

confidence: 99%

Artemisinins in Combating Viral Infections Like SARS-CoV-2, Inflammation and Cancers and Options to Meet Increased Global Demand

et al. 2022

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Graphical AbstractThree anti-SARS-CoV-2 potentials of artemisinin and artesunate. Artemisinin (ART) and artesunate (AS) may (1) block interaction of viral spike protein with the human ACE2 receptors, preventing viral endocytosis and activation of the NF-κB signaling pathway, (2) ART and AS may block activation of NF-κB signaling pathway by IKK, or (3) may interfere directly with p50/p65 transcriptional activity in human cells.

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“…12 And Africa has a long history of traditional medicine and practitioners that play a crucial role in providing care to populations. 13,14 Medicinal plants such as Artemisia annua are considered as possible treatments for COVID-19 15,16 And such practices need to be tested for efficacy and safety. The Zone is rich in natural flora, and there are many known traditional medicine practitioners (>115) in the study area.…”

Section: Introductionmentioning

confidence: 99%

Traditional Medicine Practice in the Context of COVID-19 Pandemic: Community Claim in Jimma Zone, Oromia, Ethiopia

Chali¹,

Melaku²,

Berhanu³

et al. 2021

IDR

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Purpose: To assess traditional medicine practice claims by the community for the prevention and treatment of COVID-19. Methods: A community-based cross-sectional study design was conducted among 422 households of Jimma Zone, and the data were collected by interviewing individuals from the selected households. The medicinal plants were recorded on Microsoft excel 2010 with their parts used, dosage form, route of administration and source of plants and tabulated in the table. Descriptive statistics were used to describe and organize the data. The Relative Frequency of Citation (RFC) was calculated for each traditional medicine to identify the top 10 medicinal products. Results: Around 46% of participants used traditional medicines for the prevention and treatment of COVID-19. The study recorded 32 herbal and non-herbal medicinal products. Garlic (RFC: 0.166), ginger (RFC: 0.133), lemon (RFC: 0.133), garden cress (RFC: 0.069) and "Damakase" (RFC: 0.031) were the frequently used herbal medicines. Seeds (47.22%) and leaves (30.56%) were the most used parts of medicinal plants. Most preparation of medicinal plants (90.63%) was administered through the oral route. The majority of medicinal plants were from home gardens. Conclusions and Recommendations: Around half of the participants practiced traditional medicines for COVID-19. Garlic, ginger, lemon, garden cress and "Damakase" were the frequently used herbal products. Seeds and leaves were regularly used parts. The oral route is the most used route of administration. The majority of medicinal plants were from home gardens. This quantity of traditional medicine practice is probably challenging to control the pandemic. However, it might open possibilities for pharmaceutical industries and researchers to look into the effectiveness and safety of claimed medicinal products. Therefore, all responsible bodies are advocated to behave accordingly.

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Artemisia and Artemisia-based products for COVID-19 management: current state and future perspective

Cited by 18 publications

References 51 publications

RETRACTED: Artemisia Extracts and Artemisinin-Based Antimalarials for COVID-19 Management: Could These Be Effective Antivirals for COVID-19 Treatment?

RETRACTED: Artemisia Extracts and Artemisinin-Based Antimalarials for COVID-19 Management: Could These Be Effective Antivirals for COVID-19 Treatment?

Artemisinins in Combating Viral Infections Like SARS-CoV-2, Inflammation and Cancers and Options to Meet Increased Global Demand

Traditional Medicine Practice in the Context of COVID-19 Pandemic: Community Claim in Jimma Zone, Oromia, Ethiopia

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