Artemisia: a promising plant for the treatment of cancer

Taleghani, Akram; Emami, Seyed Ahmad; Tayarani‐Najaran, Zahra

doi:10.1016/j.bmc.2019.115180

Cited by 67 publications

(36 citation statements)

References 192 publications

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“…Lang et al [30] demonstrated that Artemisia annua extract free of artemisinin has antitumor activity in vitro and in vivo and identified active compounds. In vitro data were validated in two in vivo cancer models, the chick chorioallantoic membrane ( Essential oil isolated from Artemisia annua (100 µg/mL) induced apoptosis in SMMC-7721 hepatocarcinoma cells by nuclear chromatin fragmentation and cytoplasmic condensation [178].…”

Section: Cytotoxic and Antitumor Effectsmentioning

confidence: 99%

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Artemisia annua, a Traditional Plant Brought to Light

Septembre-Malaterre

Rakoto

Marodon³

et al. 2020

IJMS

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Traditional remedies have been used for thousand years for the prevention and treatment of infectious diseases, particularly in developing countries. Of growing interest, the plant Artemisia annua, known for its malarial properties, has been studied for its numerous biological activities including metabolic, anti-tumor, anti-microbial and immunomodulatory properties. Artemisia annua is very rich in secondary metabolites such as monoterpenes, sesquiterpenes and phenolic compounds, of which the biological properties have been extensively studied. The purpose of this review is to gather and describe the data concerning the main chemical components produced by Artemisia annua and to describe the state of the art about the biological activities reported for this plant and its compounds beyond malaria.

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Section: Cytotoxic and Antitumor Effectsmentioning

confidence: 99%

“…Essential oil isolated from Artemisia annua (100 µg/mL) induced apoptosis in SMMC-7721 hepatocarcinoma cells by nuclear chromatin fragmentation and cytoplasmic condensation [ 178 ].…”

Section: Biological Activities Of Artemisia Annuamentioning

confidence: 99%

Artemisia annua, a Traditional Plant Brought to Light

Septembre-Malaterre

Rakoto

Marodon³

et al. 2020

IJMS

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“…Artemisia genus comprises several species and some are among the most used plants in traditional Chinese medicine for the treatment of infectious diseases produced by fungi, bacteria and viruses ( Abad et al, 2012 ; Abad. et al, 2012 ; Bora and Sharma, 2011 ; Pandey and Singh, 2017 ; Taleghani et al, 2020 ; Tan et al, 1998 ). The best–known compound isolated from an Artemisia species ( A. annua ) is an endoperoxide sesquiterpene lactone sesquiterpene, artemisinin, an antimalarial drug used in artemisinin combination therapies (ACT) which is active against the intraerythrocytic forms of Plasmodium falciparum by preventing the detoxification of hemodigestion products ( Talman et al, 2019 ).…”

Section: Introductionmentioning

confidence: 98%

“…The best–known compound isolated from an Artemisia species ( A. annua ) is an endoperoxide sesquiterpene lactone sesquiterpene, artemisinin, an antimalarial drug used in artemisinin combination therapies (ACT) which is active against the intraerythrocytic forms of Plasmodium falciparum by preventing the detoxification of hemodigestion products ( Talman et al, 2019 ). Novel derivatives have been tested for their activity against malaria or other infectious diseases (for a review see Efferth, 2018 ; Liu et al, 2019 ; Taleghani et al, 2020 ).…”

Section: Introductionmentioning

confidence: 99%

Ethanolic extract of Artemisia campestris subsp. glutinosa (Besser) Batt. inhibits HIV–1 replication in vitro through the activity of terpenes and flavonoids on viral entry and NF–κB pathway

Ticona

Bermejo

Guerra

et al. 2020

Journal of Ethnopharmacology

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Ethno–pharmacological relevance The genus Artemisia spp. is well known for its anti–infectious properties and its high content in anti–infectious compounds, like the well–known sweet wormwood ( Artemisia annua L.). Another Artemisia species, Artemisia campestris subsp. glutinosa (Besser) Batt., field wormwood, has been traditionally used as medicinal plant in the Mediterranean region. Aim of the study The aim of this study is to investigate the anti–HIV activity of field wormwood, to identify the compounds responsible for this activity and their structure and mechanism of action. Materials and methods Antiviral activity of isolated compounds and extracts was evaluated in HIV–1 infections of lymphoblastoid cells. We also evaluated the mechanism of action of isolated compounds. Viral entry was studied comparing the inhibitory effect of isolated compounds on wild type HIV–1 and VSV pseudotyped HIV–1. To assess the viral transcriptional effect, plasmids encoding luciferase reporter genes under the control of the whole genome of HIV–1 or NF–κB or Sp1 transcription factors were transfected in the presence of the compounds under evaluation. Finally, antioxidant activity was assessed by quantitation of reduced and total glutathione in treated cell cultures. Results Ethanolic and aqueous extracts of Artemisia campestris subsp. glutinosa (Besser) Batt. subsp. g lutinosa displayed anti–HIV activity in vitro , although ethanolic extract was more powerful (IC 50 14.62 μg/mL). Bio–guided ethanolic extract fractionation leads to the isolation and characterization of two terpenes, damsin and canrenone, and four flavonoids, 6, 2′, 4′–trimethoxyflavone, acerosin, cardamonin and xanthomicrol. All the isolated compounds inhibited HIV–1 replication in vitro with IC 50 values between the middle nanomolar and the low micromolar range. Their anti–HIV mechanism of action is due to the bloking of viral entry and/or transcription inhibition, without correlation with the antioxidant activity, through interference with the cellular transcription factors NF–κB and Sp1, which are targets that are not currently reached by antiretroviral therapy. Conclusion We describe here the anti–HIV activity of field wormwood, Artemisia campestris subsp. glutinosa (Besser) Batt., and the isolation and study of the mechanism of action of two terpenes and four flavonoids, responsible, at least in part, for its activity, through the inhibition of two different cellular targets affecting the HIV replication cycle. The activity of these compounds in cellular targets could explain why plant extracts can be used in t...

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“…Artemisia , the genus belongs to the family Asteraceae, containing 200–400 species dispersed mainly in the mild zones of Asia, Europe, and North America [19, 20]. Artemisia kopetdaghensis (Fig.…”

Section: Introductionmentioning

confidence: 99%