Arteether nanoemulsion for enhanced efficacy against Plasmodium yoelii nigeriensis malaria: An approach by enhanced bioavailability

Dwivedi, Pankaj; Khatik, Renuka; Chaturvedi, Priyanka; Khandelwal, Kiran; Taneja, Isha; Raju, K. Kanaka; Dwivedi, Hemlata; Singh, Sunil Kumar; Gupta, Pramod; Shukla, Prashant; Tripathi, Priyanka; Singh, Sarika; Tripathi, Renu; Wahajuddin,; Paliwal, Sarvesh; Dwivedi, Anil Kumar; Mishra, Prabhat Ranjan

doi:10.1016/j.colsurfb.2014.12.052

Cited by 33 publications

(8 citation statements)

References 39 publications

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“…The pharmacokinetic study showed significantly enhanced bioavailability of ARTE in ARTE-NE. The ARTE-NE showed significantly high antimalarial efficacy and survival rate of mice giving 80% cure rate at 12.5 mg/kg for 5 days in comparison to 30% cure rate of ARTE in groundnut oil at the same daily dose and it was also comparable to the 100% cure rate at 12.5 mg/kg for 5 days for ART given intramuscularly [153].…”

Section: Nanoemulsionmentioning

confidence: 77%

Exploring Nanotechnologies for the Effective Therapy of Malaria Using Plant-Based Medicines

Oga¹,

Singh

2016

CPD

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Malaria is a potentially lethal disease caused by species of the plasmodium parasite. Despite the advances in the interventions for its control and approaches to manage fatality, morbidity and mortality rates associated with malaria are still high. At present, artemisinin-based combination therapy is the first line of treatment. However, there is the need to explore newer approaches as reduced effectiveness and multi-drug resistance (even to artemisinin) has been reported in some regions and is expected to widen in scope. Phytomedicines have shown promise for the management of this debilitating disease and there are abundant resources in most of the areas where this disease is endemic. This report would systematically review the literature, emphasizing the challenges encountered in the control of malaria, active phytochemicals currently utilised in the management, drug delivery approaches as well as the nanotechnology-based systems that could be exploited in its treatment. These phytomedicines, either delivered conventionally or via the use of advanced delivery systems may suggest new strategies towards the better management of malaria.

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Section: Nanoemulsionmentioning

confidence: 77%

Exploring Nanotechnologies for the Effective Therapy of Malaria Using Plant-Based Medicines

Oga¹,

Singh

2016

CPD

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“…This NE was well tolerated in the experimentally infected mice with no abnormality in behaviour, food/water consumption and general activity of the animals throughout the treatment and post treatment period. ART-NE-V, administered orally, had an 80% curative rate in comparison to the 100% cure rate achieved by intramuscular route at the same dose and to the 30% curative rate obtained in mice treated with ART in ground nut oil [183].…”

Section: Green Micro- and Nanoemulsions For Developing Antiparasitmentioning

confidence: 99%

Green Micro- and Nanoemulsions for Managing Parasites, Vectors and Pests

et al. 2019

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The management of parasites, insect pests and vectors requests development of novel, effective and eco-friendly tools. The development of resistance towards many drugs and pesticides pushed scientists to look for novel bioactive compounds endowed with multiple modes of action, and with no risk to human health and environment. Several natural products are used as alternative/complementary approaches to manage parasites, insect pests and vectors due to their high efficacy and often limited non-target toxicity. Their encapsulation into nanosystems helps overcome some hurdles related to their physicochemical properties, for instance limited stability and handling, enhancing the overall efficacy. Among different nanosystems, micro- and nanoemulsions are easy-to-use systems in terms of preparation and industrial scale-up. Different reports support their efficacy against parasites of medical importance, including Leishmania, Plasmodium and Trypanosoma as well as agricultural and stored product insect pests and vectors of human diseases, such as Aedes and Culex mosquitoes. Overall, micro- and nanoemulsions are valid options for developing promising eco-friendly tools in pest and vector management, pending proper field validation. Future research on the improvement of technical aspects as well as chronic toxicity experiments on non-target species is needed.

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“…Furthermore, the C max of formulation was 1506 ± 161.22 ng/mL which was higher when compared to arteether in groundnut oil which was 175.2 ± 16.54 ng/mL. In vivo studies further revealed a significant antimalarial efficacy of 80% cure rate at 12.5 mg/kg over a period of 5 days when compared to 30% cure rate of arteether in ground nut oil at the same daily dose [ 176 ]. Memvanga and Préat reported nanoemulsions of β-arteether for oral administration.…”

Section: Nanoparticlesmentioning

confidence: 99%

Nanoparticles Formulations of Artemisinin and Derivatives as Potential Therapeutics for the Treatment of Cancer, Leishmaniasis and Malaria

Alven

Aderibigbe

2020

Pharmaceutics

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Cancer, malaria, and leishmaniasis remain the deadly diseases around the world although several strategies of treatment have been developed. However, most of the drugs used to treat the aforementioned diseases suffer from several pharmacological limitations such as poor pharmacokinetics, toxicity, drug resistance, poor bioavailability and water solubility. Artemisinin and its derivatives are antimalarial drugs. However, they also exhibit anticancer and antileishmanial activity. They have been evaluated as potential anticancer and antileishmanial drugs but their use is also limited by their poor water solubility and poor bioavailability. To overcome the aforementioned limitations associated with artemisinin and its derivatives used for the treatment of these diseases, they have been incorporated into nanoparticles. Several researchers incorporated this class of drugs into nanoparticles resulting in enhanced therapeutic outcomes. Their potential efficacy for the treatment of parasitic infections such as malaria and leishmaniasis and chronic diseases such as cancer has been reported. This review article will be focused on the nanoparticles formulations of artemisinin and derivatives for the treatment of cancer, malaria, and leishmaniasis and the biological outcomes (in vitro and in vivo).

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Arteether nanoemulsion for enhanced efficacy against Plasmodium yoelii nigeriensis malaria: An approach by enhanced bioavailability

Cited by 33 publications

References 39 publications

Exploring Nanotechnologies for the Effective Therapy of Malaria Using Plant-Based Medicines

Exploring Nanotechnologies for the Effective Therapy of Malaria Using Plant-Based Medicines

Green Micro- and Nanoemulsions for Managing Parasites, Vectors and Pests

Nanoparticles Formulations of Artemisinin and Derivatives as Potential Therapeutics for the Treatment of Cancer, Leishmaniasis and Malaria

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