Arteether for treating severe malaria

Afolabi, BB; Okoromah, Christy A. N.

doi:10.1002/14651858.cd004391

Cited by 1 publication

(1 citation statement)

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“…[40,73] Artemotil (16), originally known as "arteether," is an ethyl acetal derived from artemisinin that has an elimination half-life of 20 h and is more metabolically stable than other derivatives. [74][75][76] Artesunate ( 17) is a potent blood schizonticide derived from artemisinin and follows the same mechanism of action as the original drug. This antimalarial is powerful, especially in the treatment of advanced and potentially lethal cases of P. falciparum infection.…”

Section: F I G U R E 1 Aminoalcohol and 4-aminoquinoline Antimalarialsmentioning

confidence: 99%

Antiprotozoal agents: How have they changed over a decade?

Fernandes

Rosa

Zimmermann

et al. 2021

Archiv der Pharmazie

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Neglected tropical diseases are a diverse group of communicable diseases that are endemic in low‐ or low‐to‐middle‐income countries located in tropical and subtropical zones. The number and availability of drugs for treating these diseases are low, the administration route is inconvenient in some cases, and most of them have safety, efficacy, or adverse/toxic reaction issues. The need for developing new drugs to deal with these issues is clear, but one of the most drastic consequences of this negligence is the lack of interest in the research and development of new therapeutic options among major pharmaceutical companies. Positive changes have been achieved over the last few years, although the overall situation remains alarming. After more than one decade since the original work reviewing antiprotozoal agents came to light, now it is time to question ourselves: How has the scenario for the treatment of protozoal diseases such as malaria, leishmaniasis, human African trypanosomiasis, and American trypanosomiasis changed? This review covers the last decade in terms of the drugs currently available for the treatment of these diseases as well as the clinical candidates being currently investigated.

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