Arteannoides U–Z: Six undescribed sesquiterpenoids with anti-inflammatory activities from the aerial parts of Artemisia annua (Qinghao)

Qin, Da-Peng; Li, Ting; Shao, Jun-Ran; He, Xiaoqing; Shi, Danfeng; Wang, Zhenzhong; Xiao, Wei; Yao, Xin‐Sheng; Li, Haibo; Yu, Yang

doi:10.1016/j.fitote.2021.105002

Cited by 5 publications

(4 citation statements)

References 18 publications

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“…At high temperatures, dietary supplementation with enzymatically treated A. annua improved intestinal sIgA and IgG content, and antioxidant capacity of broilers (26). Previous reports show that sesquiterpenoids from the aerial parts of A. annua had an inhibitory activity against the production of inflammatory cytokines (PGE2, NO, IL-6, and TNF-α) in lipopolysaccharide (LPS)-induced RAW 264.7 macrophages (15). Furthermore, aqueous and alcoholic extracts of A. annua improved insulin resistance via decreasing TNFalpha and IL-6 in high-fat diet/streptozotocin-induced diabetic mice (27).…”

Section: Introductionmentioning

confidence: 98%

“…Recently, artemisinin, an antimalarial component of A. annua studied by Tu, has attracted wide attention worldwide (12). A. annua has multiple properties, such as anticancer (13), anti-malarial (14), anti-inflammatory (15), and antioxidant (11), which are related to its rich bioactive constituents, including polysaccharides (16), polyphenols (17), and flavonoids (18). It was reported that dietary inclusion of dried A. annua leaves was used for the coccidiosis treatment and growth advancement in broilers (19,20).…”

Section: Introductionmentioning

confidence: 99%

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Artemisia annua L. Aqueous Extract Promotes Intestine Immunity and Antioxidant Function in Broilers

Guo

Xing

et al. 2022

Front. Vet. Sci.

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This study was conducted to investigate the effects of Artemisia annua L. aqueous extract (AAE) on intestinal immune and antioxidative function of broilers. A total of 200 one-day-old Arbor Acre broilers were randomly allotted into five dietary treatment groups, with five replicates per treatment and eight broilers per replicate. The five treatment diets were formulated by adding, respectively, 0 (control group), 0.5, 1.0, 1.5, and 2.0 g/kg AAE in the basal diet. The results showed that dietary inclusion of AAE quadratically decreased interleukin (IL)-1β content, linearly decreased IL-6 content in the small intestine through regulating the nuclear factor-kappa B signal pathway, and quadratically increased immunoglobulin (Ig)M and sIgA content in ileum and jejunum. Besides, there was a quadratic decrease in the gene expression of IL-1β, IL-6, and toll like receptor 4 (TLR4) in ileum on day 21, and the gene expression of IL-6 and TLR4 in duodenum on day 42, thereby improving small intestinal immune function in broilers. Additionally, dietary inclusion of AAE improves antioxidative function through the nuclear factor-erythroid 2-related factor 2 (Nrf2) signal pathway in the small intestinal mucosa of broilers, especially, quadratically increased catalase (CAT) and superoxidase dismutase activity in ileum, and total antioxidant capacity and glutathione peroxidase activity in duodenum, and quadratically decreased malondialdehyde concentration in ileum, besides, linearly increased heme oxygenase-1 and Nrf2 gene expression in jejunum and ileum on day 42, quadratically increased CAT gene expression in the small intestine. Furthermore, regression analyses of the above parameters showed that the optimal dose range of AAE in the diet of broilers was 1.12–1.38 g/kg.

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Section: Introductionmentioning

confidence: 98%

Section: Introductionmentioning

confidence: 99%

Artemisia annua L. Aqueous Extract Promotes Intestine Immunity and Antioxidant Function in Broilers

Guo

Xing

et al. 2022

Front. Vet. Sci.

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“…In another study on human cell lines, [ 14 ] has found that the Artemisia annua (AA) 90% ethanol Phyto-extract showed a greater ability to reduce TNF-α oncogene expression. [ 29 ] has isolated six new sesquiterpenoids from the aerial parts of Artemisia annua , three of these compounds showed inhibitory activities against the production of inflammatory cytokines TNF-α in lipopolysaccharide (LPS)-induced (murine macrophage cell line). Our findings agree and support the previous results, where the TNF- ɑ oncogene expression levels were significantly decreased by using Artemisia annua L. extract treatment.…”

Section: Discussionmentioning

confidence: 99%

Inhibition of TNF-α Oncogene Expression by Artemisia Annua L. Extract Against Pioglitazone Side Effects in Male Albino Mice

Botrous,

Elmaghraby,

El-Achy

et al. 2023

Mol Biotechnol

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Pioglitazone (Actos) is one of the most recent oral antidiabetic drugs for treating the second type of diabetes mellitus as a common chronic and lifelong disease, but with harmful side effects. The objective of this study is to evaluate the effectiveness of Artemisia annua L. extract against the Actos drug side effects in the male albino mice. In present study, the use of Actos drug alone induced hepatotoxicity, renal inflammation, hematological disorders and bladder cancer, which are manifested by biochemical abnormalities and histopathological changes, moreover, the severity of toxicity depends on its dose. In contrast, the concurrent treatment with both Actos drug (45 mg/kg) and Artemisia extract (4 g/kg) was effective against the harmful side effects of the Actos drug. Where, the biochemical, hematological and histopathological investigations showed that the hepatotoxicity, renal inflammation, hematological disorders and histopathological changes were improved using combination of Actos and Artemisia extract. In addition, the results of TNF-ɑ oncogene expression levels in bladder tissues were significantly decreased by about 99.99% using the mix of both Actos drug and Artemisia extract. In conclusion, these findings reveal that the Artemisia annua extract on TNF-ɑ oncogene expression level is very significant and effective natural product against harmful side effects of pioglitazone which associated with an increased risk of incident bladder cancer among people, but for application more studies must be achieved in that field.

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“…Abeo-amorphane sesquiterpene Sesquiterpene [23] (Z)-7-Acetoxy-methyl-11-methyl-3-methylenedodeca-1,6,10triene Sesquiterpenes [24] Apigenin-6-C-hexoside-8-C-pentoside Flavonoid [10] Arteannoides A to E Sesquiterpene [25] Arteannoides F to R Sesquiterpene [26] Arteannoides U to Z Sesquiterpenes [25] Artemisinic acid, 6α-peroxy ester Sesquiterpene [23] Artemisiannuside A Coumarin glycoside [27] Artemanin A Sesquiterpene [ Mannose Sugar [37] Maritimin Sesquiterpene [36] 4-O-Methylglucuronic acid Organic acid [37] Reynosin Sesquiterpene [36] Rhamnose Sugar [37] Rutin Flavonoid…”

Section: Artemisia Annuamentioning

confidence: 99%

Secondary Metabolites Isolated from Artemisia afra and Artemisia annua and Their Anti-Malarial, Anti-Inflammatory and Immunomodulating Properties—Pharmacokinetics and Pharmacodynamics: A Review

et al. 2023

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There are over 500 species of the genus Artemisia in the Asteraceae family distributed over the globe, with varying potentials to treat different ailments. Following the isolation of artemisinin (a potent anti-malarial compound with a sesquiterpene backbone) from Artemisia annua, the phytochemical composition of this species has been of interest over recent decades. Additionally, the number of phytochemical investigations of other species, including those of Artemisia afra in a search for new molecules with pharmacological potentials, has increased in recent years. This has led to the isolation of several compounds from both species, including a majority of monoterpenes, sesquiterpenes, and polyphenols with varying pharmacological activities. This review aims to discuss the most important compounds present in both plant species with anti-malarial properties, anti-inflammatory potentials, and immunomodulating properties, with an emphasis on their pharmacokinetics and pharmacodynamics properties. Additionally, the toxicity of both plants and their anti-malaria properties, including those of other species in the genus Artemisia, is discussed. As such, data were collected via a thorough literature search in web databases, such as ResearchGate, ScienceDirect, Google scholar, PubMed, Phytochemical and Ethnobotanical databases, up to 2022. A distinction was made between compounds involved in a direct anti-plasmodial activity and those expressing anti-inflammatory and immunomodulating activities or anti-fever properties. For pharmacokinetics activities, a distinction was made between compounds influencing bioavailability (CYP effect or P-Glycoprotein effect) and those affecting the stability of pharmacodynamic active components.

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Arteannoides U–Z: Six undescribed sesquiterpenoids with anti-inflammatory activities from the aerial parts of Artemisia annua (Qinghao)

Cited by 5 publications

References 18 publications

Artemisia annua L. Aqueous Extract Promotes Intestine Immunity and Antioxidant Function in Broilers

Artemisia annua L. Aqueous Extract Promotes Intestine Immunity and Antioxidant Function in Broilers

Inhibition of TNF-α Oncogene Expression by Artemisia Annua L. Extract Against Pioglitazone Side Effects in Male Albino Mice

Secondary Metabolites Isolated from Artemisia afra and Artemisia annua and Their Anti-Malarial, Anti-Inflammatory and Immunomodulating Properties—Pharmacokinetics and Pharmacodynamics: A Review

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