Art therapy for Parkinson's disease

Cucca, Alberto; Rocco, Alessandro Di; Acosta, Ikuko; Beheshti, Mahya; Berberian, Marygrace; Bertisch, Hilary; Droby, Amgad; Ettinger, Tom; Hudson, Todd E.; Inglese, Matilde; Jung, Yoon Jung; Mania, Daniella; Quartarone, Angelo; Rizzo, John Ross; Sharma, Kush; Feigin, Andrew; Biagioni, Milton; Ghilardi, Maria Felice

doi:10.1016/j.parkreldis.2021.01.013

Cited by 32 publications

(32 citation statements)

References 30 publications

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“…Efficient cognition fundamentally relies on the integrative functions of between-network communication, while motor execution is underpinned by within-network communication. 8 In our findings, a significant association was observed between the MDT decline in state I and motor exacerbation. This may be ascribed to diminished integrative function within the networks of VN, SMN, and DAN.…”

Section: Discussionsupporting

confidence: 60%

Dynamic functional connectivity assesses the progression of Parkinson��s disease

Li,

Chen,

Zeng

et al. 2023

TIME

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<p>Parkinson��s disease (PD) induces functional connectivity (FC) changes during its course. However, the impact of PD progression on the temporal properties of FC remains ambiguous. In the current study, we aimed to uncover longitudinal shifts in dynamic FC (DFC) temporal properties of brain networks during PD progression, proposing a novel biomarker for PD progression evaluation. We conducted a longitudinal study on 45 PD patients from the Parkinson��s Progression Markers Initiative database. Patients underwent dual-timepoint neurological assessments and resting-state fMRI scans at baseline and 1-4 years of subsequent follow-up. The sliding-window technique and k-means clustering were employed to scrutinize DFC patterns of the entire brain network, including individual cortical subnetworks and subcortical nuclei (SN) at every timepoint. From this analysis, DFC analyses revealed two predominant states: a high-frequency sparse FC state and a low-frequency intense FC state. For the entire brain network, the mean dwell time (MDT) in the sparse FC state diminished with PD progression, and this decrease was closely tied to motor deterioration. Concerning cortical subnetworks and SN, MDTs in the sparse FC state reduced at the second timepoint in both visual (VN) and limbic networks (LN) linked with the SN. The MDT reduction in LN-SN positively correlated with cognitive decline, while the MDT reduction in VN-SN showed a strong link with motor degradation. These results emphasize that DFC might offer insights into the evolving brain dynamics in PD patients over the disease's course, underscoring its prospective utility as a progression biomarker.</p>

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Section: Discussionsupporting

confidence: 60%

Dynamic functional connectivity assesses the progression of Parkinson��s disease

Li,

Chen,

Zeng

et al. 2023

TIME

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“…The use of MoBI would enable-for the first time-an evaluation of cortical physiology in patients who have Parkinson's disease in their states of greatest symptomatology (i.e., mobility). Cucca et al (2018;Cucca et al, 2021) (Dissanayaka et al, 2010). In many cases, the environment is a source of enhanced stress and anxiety, be it from fear of falling, fear of freezing, or more complex thoughts of function and perception.…”

mentioning

confidence: 99%

Using mobile brain/body imaging to advance research in arts, health, and related therapeutics

King

Parada

2021

Eur J of Neuroscience

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The uses of mobile brain/body imaging (MoBI) are expanding and allow for more direct study of the neurophysiological signals associated with behavior in psychotherapeutic encounters. Neuroaesthetics is concerned with the cognitive and neural basis of art appreciation, and scientific correlations are being made in the field that might help to clarify theories claimed in the creative arts therapies. Yet, most neuroaesthetics studies are confined to the laboratory and do not propose a translation for research methods and clinical applications. The creative arts therapies have a long history of clinical success with various patient populations and will benefit from increased scientific explanation to support intervention strategies. Examining the brain dynamics and motor behaviors that are associated with the higher complex processes involved in artistic expression offers MoBI as a promising instrumentation to move forward in linking ideas from neuroaesthetics to the creative arts therapies. Tracking brain dynamics in association with behavioral change allows for more objective and quantitative physiological monitors to evaluate, and together with subjective patient reports provides insight into the psychological mechanisms of change in treatment. We outline a framework that shows how MoBI can be used to study the effectiveness of creative arts therapy interventions motivated by the 4E approach to cognition with a focus on visual art therapy. The article illuminates how a new partnership among the fields of art therapy, neuroscience, and neuroaesthetics might work together within the 4E/MoBI framework in efforts to advance transdisciplinary research for clinical health populations.

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“… 70 Art therapy has been shown to improve visual-cognitive skills and visual exploration strategies as well as general motor functions in Parkinson’s disease. 71 Moreover, these improvements were associated with increased connectivity within primary and associative visual networks. Our results indicating impaired connections of sensorimotor connector hubs to primary processing networks including visual and sensorimotor suggest that the integration of various information from these networks may be significantly affected in patients with Parkinson’s disease.…”

Section: Discussionmentioning

confidence: 99%

Connectivity impairment of cerebellar and sensorimotor connector hubs in Parkinson’s disease

Bagarinao

Kawabata

Watanabe

et al. 2022

Brain Communications

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Cognitive and movement processes involved integration of several large-scale brain networks. Central to these integrative processes are connector hubs, brain regions characterized by strong connections with multiple networks. Growing evidence suggests that many neurodegenerative and psychiatric disorders are associated with connector hub dysfunctions. Using a network metric called functional connectivity overlap ratio, we investigated connector hub alterations in Parkinson’s disease. Resting state functional MRI data from 99 patients (male/female = 44/55) and 99 age- and sex-matched healthy controls (male/female = 39/60) participating in our cross-sectional study were used in the analysis. We have identified two sets of connector hubs, mainly located in the sensorimotor cortex and cerebellum, with significant connectivity alterations with multiple resting state networks. Sensorimotor connector hubs have impaired connections primarily with primary processing (sensorimotor, visual), visuospatial, and basal ganglia networks, whereas cerebellar connector hubs have impaired connections with basal ganglia and executive control networks. These connectivity alterations correlated with patients’ motor symptoms. Specifically, values of the functional connectivity overlap ratio of the cerebellar connector hubs were associated with tremor score, whereas that of the sensorimotor connector hubs with postural instability and gait disturbance score, suggesting potential association of each set of connector hubs with the disorder’s two predominant forms, the akinesia/rigidity and resting tremor subtypes. In addition, values of the functional connectivity overlap ratio of the sensorimotor connector hubs were highly predictive in classifying patients from controls with an accuracy of 75.76%. These findings suggest that, together with the basal ganglia, cerebellar and sensorimotor connector hubs are significantly involved in Parkinson’s disease with their connectivity dysfunction potentially driving the clinical manifestations typically observed in this disorder.

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Art therapy for Parkinson's disease

Cited by 32 publications

References 30 publications

Dynamic functional connectivity assesses the progression of Parkinson��s disease

Dynamic functional connectivity assesses the progression of Parkinson��s disease

Using mobile brain/body imaging to advance research in arts, health, and related therapeutics

Connectivity impairment of cerebellar and sensorimotor connector hubs in Parkinson’s disease

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