ART outcome in young women with premature ovarian aging

Dua, Meenakshi; Bhatia, Vandana; Malik, Sonia; Prakash, Ved

doi:10.4103/0976-7800.122257

Cited by 8 publications

(13 citation statements)

References 5 publications

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“…This fact implies that elevated basal FSH is associated with low ovarian reserve, but is not linked to poor oocyte quality and early embryo quality. This finding is illustrated in several other studies including Karimzadeh & Ghandhi [7] and Meenakshi et al [13].…”

Section: Discussionsupporting

confidence: 67%

Can Elevated Levels of Basal Follicle Stimulating Hormone Predict a Decrease in Fertility in Young Women Undergoing ART Cycles?

Jellad¹

2016

OGIJ

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Background: The determination of ovarian reserve is often measured in normal cycling women through day 3 basal FSH. This determination will help to choose patients who are eligible for starting assisted reproductive technique (ART) cycles. Female age and basal FSH level are independently associated with IVF outcome.Objective: This study aims' at evaluating the impact of basal FSH level associated with female age on IVF outcome. Methods:A retrospective study that included 367 patients undergoing ICSI cycles. Basal FSH levels were measured using the same immunoenzymatic method for all patients. The age of women was checked before they were undergoing pituitary desensitization. Patients were divided into 4 groups according to their age and basal FSH levels. Then its correlation with IVF outcome was evaluated. Results:The increase of FSH levels was associated significantly with reduced oocytes retrieved, and embryos obtained in young women. Nevertheless, there was no significant difference in terms of fertilization or pregnancy rate. Cancellation rates were significantly higher among patients with high day 3 FSH levels compared to patients having normal FSH levels in all age groups. Loss rates were affected by FSH levels among patients < 38 years old. However, they were significantly higher in older patients having elevated day 3 FSH levels. Younger women with high FSH levels produced less but better quality embryos resulting in acceptable pregnancy rate. Conclusion:Female age is the most important prognostic factor. The basal FSH should be used to identify women who are purveyors of poor response to ART and should not be used to exclude them from fertility treatment.

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Section: Discussionsupporting

confidence: 67%

Can Elevated Levels of Basal Follicle Stimulating Hormone Predict a Decrease in Fertility in Young Women Undergoing ART Cycles?

Jellad¹

2016

OGIJ

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“…As we know that follicle depletion increases six times after 39 years of age [ 3 , 22 ], and most clinical trials considered important changes in ovarian response after 38 years of age [ 23 , 24 ], we excluded patients more than 38 years of age in the present study.…”

Section: Discussionmentioning

confidence: 99%

ESR1 and ESR2 gene polymorphisms are associated with human reproduction outcomes in Brazilian women

et al. 2014

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BackgroundImportant candidate genes involved in the ovarian response to exogenous FSH are the estrogen receptor genes (ESRs), since the effects of estrogens on follicle growth, maturation and oocyte release. It is known that some markers of ovarian stimulation can help to personalize the treatment, adjusting the dose of exogenous rFSH, thus preventing excessive wear of the patient. Inspired on this information we aimed to analyze four different polymorphisms in the estrogen receptor genes ESR1: rs2234693/T-397C (PvuII) and rs9340799/A-351G (Xbal) and ESR2: rs4986938/G1082A (RsaI) and rs1256049/A + 1730G (AluI), and their association with assisted reproduction outcomes in Brazilian women that underwent in vitro fertilization (IVF).MethodsA cross-sectional study was performed involving 136 infertile women less than 39 years of age with normal ovarian reserve. Patients were divided according to the same COH protocol for statistical analysis. The Taqman assay was used for PvuII and XbaI of ESR1, and RsaI and AluI of ESR2 genotyping. Serum estradiol and FSH were measured by Elisa assay.ResultsThe PvuII (ESR1) TT and RsaI (ESR2) GG genotypes were associated with a longer induction period and higher doses of medication (p < 0.03). The XbaI (ESR1) AA genotype was associated with better COH results, including a larger number of follicles, mature oocytes, embryos, and good quality embryos (p < 0.05). The AluI GG genotype showed an association with the Ovarian Hyperstimulation Syndrome (OHSS) (p = 0.03). According to the haplotype analysis of ER1 (PvuII/XbaI), we demonstrated that the CA combination increases by 0.68 the number of good quality embryos while the TG decreases it by 0.71 (p = 0.04).ConclusionER polymorphisms have an association with the assisted reproduction outcomes in Brazilian women.

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“…The evaluation of OR allows to identify cases of premature ovarian insufficiency and provide the opportunity to design programs for egg freezing preservation and egg donation. In addition, OR can predicts the success of the assisted reproductive techniques, oncofertility programs, and infertility counseling programs [3][4][5].…”

Section: Introductionmentioning

confidence: 99%

“…A diminished OR (DOR) is related to the decline of the potential of female fertility that accompanies the normal ovarian aging [6].In some cases OR declines before 40 years which is a condition previously known as premature menopause, premature ovarian failure, or early menopause characterized by amenorrhea, hipoestrogenism, and elevated levels serum gonadotropins levels [6]. The decreasing of OR gives rise lower pregnancy rates, repetitive implantation failure, and high risk of miscarriages [3,[7][8][9][10]. The negative impact of DOR forces to organize early programs of detection that prevents numerous cases of woman infertility [6,11,12].…”

Section: Introductionmentioning

confidence: 99%

Ovarian Reserve Markers: An Update

Moreno-Ortíz¹,

Acosta²,

Lucena-Quevedo³

et al. 2018

Biomarker - Indicator of Abnormal Physiological Process

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Ovarian reserve (OR) is defined as the pool of follicles available to provide eggs cells throughout the fertile age in each woman and define the potential of fertility to predict the reproductive lifespan of women. Several studies have focused on the clinical use in order to identify women with a decreased ovarian function and to improve the clinical approach to these patients. In this chapter we will describe different OR markers such as antimullerian hormone (AMH) and follicle stimulating hormone (FSH), count by ultrasound of antral follicles (AFC) and ovarian volume. The measure of OR markers has been reported as an effective test to predict a possible failure of reproductive capacity and important tool in the primary prevention of infertility and other related problems. Therefore, we will show the clinical use of these markers in both healthy and infertile women studies. Additionally, we describe the most recent and promising progress in the OR evaluation by construction of algorithms.

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ART outcome in young women with premature ovarian aging

Cited by 8 publications

References 5 publications

Can Elevated Levels of Basal Follicle Stimulating Hormone Predict a Decrease in Fertility in Young Women Undergoing ART Cycles?

Can Elevated Levels of Basal Follicle Stimulating Hormone Predict a Decrease in Fertility in Young Women Undergoing ART Cycles?

ESR1 and ESR2 gene polymorphisms are associated with human reproduction outcomes in Brazilian women

Ovarian Reserve Markers: An Update

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