Art of using maintenance therapy in a patient with metastatic colon cancer harboring RAS-wt/BRAF V600E

Abstract

Background: Colorectal cancer is one of the most common malignancies with a high rate of liver metastasis, and various gene mutations have been proven to be involved in its pathogenesis. One of them is BRAF gene mutations, the most frequent of which-V600E-has a poor prognosis in patients with colon cancer. Case presentation: By applying the FOLFIRINOX regimen and a specific maintenance strategy containing vemurafenib, we achieved disappearance of metastatic lesions, no recurrence, and good stability in a Kurdish patient with metastatic colon cancer harboring RASwt/BRAF V600E. Conclusion: Our therapeutic strategy allows the selection of the most appropriate treatment approach for patients.