Arsenite enhances tumor necrosis factor-α-induced expression of vascular cell adhesion molecule-1

Tsou, Tsui‐Chun; Yeh, Szu Ching; Tsai, Eing‐Mei; Tsai, Feng-Yuan; Chao, How‐Ran; Chang, Louis W.

doi:10.1016/j.taap.2005.03.006

Cited by 34 publications

(19 citation statements)

References 41 publications

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“…VED, a marker of atherosclerotic risk, is often associated with the pathogenesis of various chronic disorders such as atherosclerosis [24], hypertension [25], heart failure [17] and diabetic nephropathy [26]. The exposure of endothelial cells to sodium arsenite induces endothelial cytotoxicity by inactivating protein kinase B/Akt and eNOS [27]. Further, an in vitro study revealed that arsenite stimulates the release of reactive oxygen species (ROS) through an activation of NADPH oxidase and increases the peroxynitrite formation in vascular endothelial cells and bovine aortic endothelial cells [28,29].…”

Section: Arsenic and Endothelial Dysfunctionmentioning

confidence: 99%

Arsenic Exposure and Cardiovascular Disorders: An Overview

2009

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The incidence of arsenic toxicity has been observed in various countries including Taiwan, Bangladesh, India, Argentina, Australia, Chile, China, Hungary, Peru, Thailand, Mexico and United States of America. Arsenic is a ubiquitous element present in drinking water, and its exposure is associated with various cardiovascular disorders. Arsenic exposure plays a key role in the pathogenesis of vascular endothelial dysfunction as it inactivates endothelial nitric oxide synthase, leading to reduction in the generation and bioavailability of nitric oxide. In addition, the chronic arsenic exposure induces high oxidative stress, which may affect the structure and function of cardiovascular system. Further, the arsenic exposure has been noted to induce atherosclerosis by increasing the platelet aggregation and reducing fibrinolysis. Moreover, arsenic exposure may cause arrhythmia by increasing the QT interval and accelerating the cellular calcium overload. The chronic exposure to arsenic upregulates the expression of tumor necrosis factor-alpha, interleukin-1, vascular cell adhesion molecule and vascular endothelial growth factor to induce cardiovascular pathogenesis. The present review critically discussed the detrimental role of arsenic in the cardiovascular system.

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Section: Arsenic and Endothelial Dysfunctionmentioning

confidence: 99%

Arsenic Exposure and Cardiovascular Disorders: An Overview

2009

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“…HUVECs were obtained by collagenase digestion of umbilical veins, as described previously [19] with modifications [20]. The isolated HUVECs were seeded into culture dishes coated with 0.1% gelatin and grown in M199 medium containing 20% fetal bovine serum (FBS), 2 mM l-glutamine, endothelial cell growth supplement (30 g/ml) (Sigma-Aldrich, St. Louis, MO), penicillin (100 U/ml), streptomycin (100 g/ml), and gentamycin (100 g/ml).…”

Section: Isolation and Treatments Of Huvecsmentioning

confidence: 99%

Zinc oxide particles induce inflammatory responses in vascular endothelial cells via NF-κB signaling

Tsou

Yeh

Tsai

et al. 2010

Journal of Hazardous Materials

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“…The endothelial cells, which constitute a barrier between the peripheral blood stream and inflamed tissue, also regulate recruitment and transmigration of leukocytes to the site of inflammation (Muller 2011). There is a strong body of evidence linking arsenicinduced oxidative stress and endothelial inflammation (Simeonova et al 2003;Bunderson et al 2004;Simeonova and Luster 2004;Tsou et al 2005), which is a hallmark of atherosclerosis (Libby 2002).…”

Section: Introductionmentioning

confidence: 99%