Arsenic trioxide inhibits the functions of lung fibroblasts derived from patients with idiopathic pulmonary fibrosis

Joannes, Audrey; Morzadec, Claudie; Gutierrez, Francisco Llamas; Latour, Bertrand Richard De; Wollin, Lutz; Jouneau, S.; Vernhet, Laurent

doi:10.1016/j.rmr.2022.02.049

Cited by 1 publication

(1 citation statement)

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“…Furthermore, the inhibition of myofibroblast autophagy could be aggravated by inactivating eEF2K, which facilitates the formation of myofibroblasts and subsequently accelerates the procedure of lung fibrosis. 132,133 Overall, more extensive studies of p38MAPK / eEF2K/eEF2 signaling are needed to find more effective treatments for IPF.…”

Section: Underlying Signaling Pathways Of Autophagy Involved In Ipfmentioning

confidence: 99%

The role of autophagy in idiopathic pulmonary fibrosis: from mechanisms to therapies

Yue

Zhang

Liu

et al. 2022

Ther Adv Respir Dis

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Idiopathic pulmonary fibrosis (IPF) is an interstitial pulmonary disease with an extremely poor prognosis. Autophagy is a fundamental intracellular process involved in maintaining cellular homeostasis and regulating cell survival. Autophagy deficiency has been shown to play an important role in the progression of pulmonary fibrosis. This review focused on the six steps of autophagy, as well as the interplay between autophagy and other seven pulmonary fibrosis related mechanisms, which include extracellular matrix deposition, myofibroblast differentiation, epithelial–mesenchymal transition, pulmonary epithelial cell dysfunction, apoptosis, TGF-β1 pathway, and the renin-angiotensin system. In addition, this review also summarized autophagy-related signaling pathways such as mTOR, MAPK, JAK2/STAT3 signaling, p65, and Keap1/Nrf2 signaling during the development of IPF. Furthermore, this review also illustrated the commonly used autophagy detection methods, the currently approved antifibrotic drugs pirfenidone and nintedanib, and several prospective compounds targeting autophagy for the treatment of IPF.

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Section: Underlying Signaling Pathways Of Autophagy Involved In Ipfmentioning

confidence: 99%

The role of autophagy in idiopathic pulmonary fibrosis: from mechanisms to therapies

Yue

Zhang

Liu

et al. 2022

Ther Adv Respir Dis

View full text Add to dashboard Cite

show abstract

Arsenic trioxide inhibits the functions of lung fibroblasts derived from patients with idiopathic pulmonary fibrosis

Cited by 1 publication

References 62 publications

The role of autophagy in idiopathic pulmonary fibrosis: from mechanisms to therapies

The role of autophagy in idiopathic pulmonary fibrosis: from mechanisms to therapies

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