Arsenic trioxide enhances the cytotoxic effect of cisplatin in head and neck squamous cell carcinoma cell lines

miR-483-5p determines mitochondrial fission and cisplatin sensitivity in tongue squamous cell carcinoma by targeting FIS1

“…Unless otherwise indicated, CAL27 and SCC9 cells were treated with the IC50 of cisplatin (Sigma-Aldrich, USA) for 24 h for apoptosis assays. The IC50 values of cisplatin in CAL27 and SCC9 cells are 8 × 10 −6 and 1.8 × 10 −5 M, respectively [12,13].…”

The variable chemotherapeutic response of Malabaricone-A in leukemic and solid tumor cell lines depends on the degree of redox imbalance

“…Arsenic trioxide has been extensively evaluated in leukemias and solid tumors (Dilda and Hogg 2007), wherein its IC 50 in leukemias ranged from 1 to 2 μM (Bornhauser et al 2007); however, in solid tumor cell lines, the IC 50 ranged from 2 to 50 μM (Kotowski et al 2012). …”

Trisenox induces cytotoxicity through phosphorylation of mitogen‐activated protein kinase molecules in acute leukemia cells

“…MAPK is a stress signaling molecule involved in cell cycle regulation and apoptosis in many cancer cells . Few reports indicate that TX causes apoptosis through activation/modulation of MAPK signaling molecules in various cancer cells . However, the detailed molecular mechanisms of TX‐induced cytotoxicity and MAPK signaling cascade in APL cell lines are poorly understood.…”

“…Cytotoxicity is a complex process mediated through deoxyribonucleic acid‐adduct, oxidative stress, transcriptional factors, and stress signaling leading to cell death . TX combination with cisplatin enhances cytotoxicity in head and neck squamous cell carcinoma cells and small cell lung cancer cells . This drug combination has also helped to overcome drug resistance and enhance cytotoxicity in APL cells.…”