Arsenic Trioxide Attenuated the Rejection of Major Histocompatibility Complex Fully-Mismatched Cardiac Allografts in Mice

Arsenic Trioxide Induces T Cell Apoptosis and Prolongs Islet Allograft Survival in Mice

“…We found that As 2 O 3 prolonged the survival of islet allograft, which is similar to the results obtained in the cardiac allograft model. 6 Because the level of Th1-related cytokines IFN-γ and IL-2 was reduced after As 2 O 3 treatment, we suggest the notion that As 2 O 3 plays a part in suppressing Th1 immune responses. Notably, the As 2 O 3 combine Rapa treatment induced sustained normoglycemia in four of the 8 mice more than 100 days.…”

“…5 Arsenic trioxide (As 2 O 3 ), which was recently reported to attenuate the rejection of cardiac allografts in mice, seems to be an agent with both antirejection and antitumor effects, and specifically valuable for recipients with primary tumor recurrence. 6 New evidence suggests As 2 O 3 also abrogated sclerodermatous graft-versus-host disease by killing activated T cells. 7 We previously investigated the effects of As 2 O 3 on prolonging the survival of cardiac allografts in alloantigen-primed mice and adoptive T celltransferred mice.…”

Arsenic immunotoxicity: a review

“…Studies of As influence on allogeneic immune response, i.e. rejection of MHC-mismatched allografts, suggest As disrupts the immune system’s ability to distinguish “self” from “non-self” [107,108]. In a mouse heart transplantation model, arsenic trioxide (As 2 O 3 ) significantly reduced allograft rejection relative to control [107].…”

“…rejection of MHC-mismatched allografts, suggest As disrupts the immune system’s ability to distinguish “self” from “non-self” [107,108]. In a mouse heart transplantation model, arsenic trioxide (As 2 O 3 ) significantly reduced allograft rejection relative to control [107]. Similarly, As 2 O 3 radically reduced severe symptoms of graft-versus-host disease in mice following allogeneic hematopoietic stem cell transplantation [108].…”

Arsenic trioxide inhibits accelerated allograft rejection mediated by alloreactive CD8+ memory T cells and prolongs allograft survival time

“…As 2 O 3 induces cell differentiation and inhibits angiogenesis through promotion of apoptosis [15,16]. In organ transplantation research, As 2 O 3 was found to prevent cardiac allotransplant rejection in mice [17]. Our previous works have shown that As 2 O 3 prolongs the survival of cardiac allografts in alloantigen-primed mice and adoptive T cell-transferred mice [18,19].…”